Lomotil and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Lomotil (atropine / diphenoxylate).
Diphenoxylate Food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
Atropine High Blood Pressure (Hypertension)
Minor Potential Hazard, Low plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
Lomotil drug interactions
There are 301 drug interactions with Lomotil (atropine / diphenoxylate).
Lomotil disease interactions
There are 25 disease interactions with Lomotil (atropine / diphenoxylate) which include:
- autonomic neuropathy
- GI obstruction
- glaucoma
- obstructive uropathy
- reactive airway diseases
- myasthenia gravis
- infectious diarrhea
- liver/renal
- cardiac disease
- tachycardia
- coronary artery disease
- gastric ulcer
- gastroesophageal reflux
- ulcerative colitis
- fluid/electrolytes
- hepatic/renal dysfunction
- toxic megacolon
- liver disease
- renal failure
- dehydration
- Down's syndrome
- hypertension
- hyperthyroidism
- diarrhea
- fever
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
