Digex and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Digex (amylase / cellulase / hyoscyamine / lipase / phenyltoloxamine / protease).
Phenyltoloxamine Food
Moderate Food Interaction
GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents. Use in combination may result in additive central nervous system depression and/or impairment of judgment, thinking, and psychomotor skills.
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol. Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
References (4)
- Warrington SJ, Ankier SI, Turner P (1986) "Evaluation of possible interactions between ethanol and trazodone or amitriptyline." Neuropsychobiology, 15, p. 31-7
- Gilman AG, eds., Nies AS, Rall TW, Taylor P (1990) "Goodman and Gilman's the Pharmacological Basis of Therapeutics." New York, NY: Pergamon Press Inc.
- (2012) "Product Information. Fycompa (perampanel)." Eisai Inc
- (2015) "Product Information. Rexulti (brexpiprazole)." Otsuka American Pharmaceuticals Inc
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Hyoscyamine High Blood Pressure (Hypertension)
Minor Potential Hazard, Low plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
References (7)
- (2002) "Product Information. Benadryl (diphenhydramine)." Parke-Davis
- (2001) "Product Information. Antivert (meclizine)." Roerig Division
- (2001) "Product Information. Marezine (cyclizine)." Glaxo Wellcome
- Valentin N, Staffeldt H, Kyst A (1984) "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand, 28, p. 621-4
- (2022) "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics
- (2001) "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories
- (2002) "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics
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Digex drug interactions
There are 346 drug interactions with Digex (amylase / cellulase / hyoscyamine / lipase / phenyltoloxamine / protease).
Digex disease interactions
There are 23 disease interactions with Digex (amylase / cellulase / hyoscyamine / lipase / phenyltoloxamine / protease) which include:
- autonomic neuropathy
- GI obstruction
- glaucoma
- obstructive uropathy
- reactive airway diseases
- myasthenia gravis
- infectious diarrhea
- cardiac disease
- tachycardia
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- coronary artery disease
- gastric ulcer
- gastroesophageal reflux
- ulcerative colitis
- liver disease
- renal failure
- hypertension
- hyperthyroidism
- diarrhea
- fever
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.