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Alendronate / cholecalciferol and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with alendronate / cholecalciferol which include:


multivitamins with minerals ↔ alendronate

Moderate Drug Interaction

Alendronate and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of alendronate and reduce its effectiveness. You should take multivitamin with minerals at least 30 minutes after the alendronate dose. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data


alendronate ↔ food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Food significantly decreases the bioavailability of alendronate, possibly to negligible levels.

MANAGEMENT: Alendronate should be administered with 6 to 8 ounces of plain water, at least 30 minutes before the first food, beverage, or medication of the day. Patients should remain upright for at least 30 minutes following administration of alendronate.


  1. "Product Information. Fosamax (alendronate)." Merck & Co, Inc, West Point, PA.

Alendronate / cholecalciferol drug interactions

There are 340 drug interactions with alendronate / cholecalciferol

Alendronate / cholecalciferol disease interactions

There are 12 disease interactions with alendronate / cholecalciferol which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.