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Fosamax Plus D and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Fosamax Plus D (alendronate / cholecalciferol).


Multivitamins With Minerals Alendronate

Moderate Drug Interaction

Alendronate and multivitamin with minerals should not be taken orally at the same time. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of alendronate into the bloodstream and reduce its effectiveness. You should take multivitamin with minerals at least 30 minutes after the alendronate dose. Talk to a healthcare professional if you are not sure whether a product contains something that could potentially interact with your medication or if you have questions on how to take this or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Alendronate Food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Food significantly decreases the bioavailability of alendronate, possibly to negligible levels.

MANAGEMENT: Alendronate should be administered with 6 to 8 ounces of plain water, at least 30 minutes before the first food, beverage, or medication of the day. Patients should remain upright for at least 30 minutes following administration of alendronate.


  1. (2001) "Product Information. Fosamax (alendronate)." Merck & Co., Inc

Fosamax Plus D drug interactions

There are 168 drug interactions with Fosamax Plus D (alendronate / cholecalciferol).

Fosamax Plus D disease interactions

There are 12 disease interactions with Fosamax Plus D (alendronate / cholecalciferol) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.