Zepbound Drug Interactions
Currently displaying a list of 416 drugs known to interact with Zepbound (tirzepatide).
- 16 major drug interactions
- 399 moderate drug interactions
- 1 minor drug interaction
Medications known to interact with Zepbound
Note: Showing generic names only.
A
- acetazolamide
- acetohexamide
- acrivastine
- albiglutide
- albuterol
- alclometasone topical
- aloe vera
- alogliptin
- alpelisib
- amcinonide topical
- aminophylline
- amiodarone
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- angiotensin II
- arformoterol
- aripiprazole
- armodafinil
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atomoxetine
- atropine
- azatadine
B
- beclomethasone
- belladonna
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- betamethasone
- betamethasone topical
- bexarotene
- biperiden
- bitolterol
- bortezomib
- brentuximab
- brexpiprazole
- brigatinib
- brompheniramine
- bumetanide
C
- caffeine
- calaspargase pegol
- capivasertib
- carbamazepine
- carbinoxamine
- cariprazine
- ceritinib
- chloral hydrate
- chlorcyclizine
- chlorothiazide
- chlorotrianisene
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chromic chloride hexahydrate
- chromium picolinate
- cinnamon
- cinoxacin
- ciprofloxacin
- clarithromycin
- clemastine
- clidinium
- clobetasol topical
- clocortolone topical
- clomipramine
- clozapine
- codeine
- conjugated estrogens
- conjugated estrogens topical
- copanlisib
- corticorelin
- corticotropin
- cortisone
- cosyntropin
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
D
- daclatasvir
- danazol
- darifenacin
- darunavir
- deflazacort
- delafloxacin
- desflurane
- desipramine
- desonide topical
- desoximetasone topical
- desvenlafaxine
- dexamethasone
- dexamethasone ophthalmic
- dexamethasone topical
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmethylphenidate
- dextroamphetamine
- diazoxide
- dichlorphenamide
- dicyclomine
- dienestrol topical
- diethylpropion
- diethylstilbestrol
- diflorasone topical
- digitoxin
- digoxin
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- dobutamine
- dofetilide
- dopamine
- doxapram
- doxepin
- doxepin topical
- doxylamine
- drospirenone
- dulaglutide
- duloxetine
- dyphylline
E
- enflurane
- enfortumab vedotin
- enoxacin
- ensartinib
- ephedrine
- epinephrine
- esterified estrogens
- estradiol
- estradiol topical
- estramustine
- estrone
- estropipate
- estropipate topical
- ethacrynic acid
- ethanol
- ethinyl estradiol
- etomidate
- etonogestrel
- everolimus
- exenatide
F
- felbamate
- fenfluramine
- fesoterodine
- flavoxate
- flecainide
- fludrocortisone
- fluocinolone topical
- fluocinonide topical
- fluphenazine
- flurandrenolide topical
- flurazepam
- fluticasone topical
- formoterol
- fosamprenavir
- fosphenytoin
- fospropofol
- furosemide
G
- gatifloxacin
- gemifloxacin
- ginseng
- glimepiride
- glipizide
- glucagon
- glyburide
- glycopyrrolate
- goserelin
- green tea
- grepafloxacin
- guarana
H
- halcinonide topical
- halobetasol topical
- haloperidol
- halothane
- histrelin
- hydrochlorothiazide
- hydrocortisone
- hydrocortisone topical
- hydroflumethiazide
- hydromorphone
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- iloperidone
- imipramine
- inavolisib
- indacaterol
- indapamide
- indinavir
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- isoetharine
- isoflurane
- isoniazid
- isoproterenol
K
L
- lanreotide
- lemborexant
- leuprolide
- levalbuterol
- levofloxacin
- levomilnacipran
- levonorgestrel
- levothyroxine
- levothyroxine / liothyronine
- linagliptin
- liothyronine
- liotrix
- liraglutide
- lisdexamfetamine
- lithium
- lixisenatide
- lomefloxacin
- lonapegsomatropin
- loncastuximab tesirine
- lorcaserin
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- maprotiline
- mazindol
- meclizine
- medroxyprogesterone
- megestrol
- melatonin
- mepenzolate
- meperidine
- mephentermine
- mephobarbital
- mesoridazine
- metaproterenol
- metaraminol
- methadone
- methamphetamine
- methazolamide
- methdilazine
- methohexital
- methotrimeprazine
- methoxamine
- methoxyflurane
- methscopolamine
- methyclothiazide
- methylphenidate
- methylprednisolone
- methylprednisolone topical
- metolazone
- mexiletine
- midodrine
- midostaurin
- milnacipran
- modafinil
- molindone
- mometasone topical
- morphine
- moxifloxacin
- mycophenolate mofetil
- mycophenolic acid
N
- nalidixic acid
- nateglinide
- nelfinavir
- niacin
- niacinamide
- nicotinamide
- nitrous oxide
- norepinephrine
- norethindrone
- norfloxacin
- norgestrel
- nortriptyline
O
- octreotide
- ofloxacin
- olanzapine
- olodaterol
- omacetaxine
- orlistat
- orphenadrine
- oxtriphylline
- oxybutynin
- oxycodone
P
- paliperidone
- paraldehyde
- pasireotide
- pegaspargase
- pegvisomant
- pemoline
- pentamidine
- pentazocine
- perphenazine
- phendimetrazine
- phenindamine
- phenobarbital
- phentermine
- phenylephrine
- phenylpropanolamine
- phenytoin
- pimozide
- pirbuterol
- pitolisant
- polythiazide
- prednicarbate topical
- prednisolone
- prednisone
- primidone
- procainamide
- prochlorperazine
- procyclidine
- progesterone
- progesterone topical
- promazine
- promethazine
- propafenone
- propantheline
- propiomazine
- propofol
- propoxyphene
- protriptyline
- pseudoephedrine
- pyrilamine
Q
R
S
- salmeterol
- saquinavir
- saxagliptin
- scopolamine
- secobarbital
- semaglutide
- sermorelin
- sevoflurane
- sibutramine
- simeprevir
- sirolimus
- sirolimus protein-bound
- sitagliptin
- sodium oxybate
- sofosbuvir
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotalol
- sparfloxacin
- sucralfate
- suvorexant
T
- tacrolimus
- tagraxofusp
- tapentadol
- temazepam
- temsirolimus
- teprotumumab
- terbutaline
- tesamorelin
- theophylline
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- thyrotropin alpha
- tipranavir
- tolazamide
- tolbutamide
- tolterodine
- torsemide
- tramadol
- triamcinolone
- triamcinolone ophthalmic
- triamcinolone topical
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimipramine
- tripelennamine
- triprolidine
- triptorelin
- trospium
- trovafloxacin
- turmeric
V
W
Z
Zepbound alcohol/food interactions
There are 3 alcohol/food interactions with Zepbound (tirzepatide).
Zepbound disease interactions
There are 5 disease interactions with Zepbound (tirzepatide) which include:
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
