Safinamide Drug Interactions
Currently displaying a list of 487 drugs known to interact with safinamide.
- 72 major drug interactions
- 413 moderate drug interactions
- 2 minor drug interactions
Medications known to interact with safinamide
Note: Showing generic names only.
5
A
- acebutolol
- acetohexamide
- acetylcarbromal
- acrivastine
- afatinib
- albuterol
- aldesleukin
- alfentanil
- alfuzosin
- aliskiren
- allopurinol
- alpelisib
- alprazolam
- amiloride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amyl nitrite
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- arformoterol
- aripiprazole
- artesunate
- asenapine
- atenolol
- atomoxetine
- avanafil
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- benazepril
- bendroflumethiazide
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- betaxolol ophthalmic
- binimetinib
- biperiden
- bisoprolol
- bitolterol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- candesartan
- cannabidiol
- cannabis
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carteolol ophthalmic
- carvedilol
- cenobamate
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- citalopram
- clemastine
- clevidipine
- clobazam
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cyclandelate
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dantrolene
- daridorexant
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- diethylpropion
- difelikefalin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- dipivefrin ophthalmic
- disulfiram
- divalproex sodium
- dopamine
- doxapram
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
E
- eltrombopag
- empagliflozin
- enalapril
- enalaprilat
- entacapone
- ephedrine
- ephedrine nasal
- epinephrine ophthalmic
- epinephrine topical
- eplerenone
- epoprostenol
- eprosartan
- ergotamine
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethaverine
- ethchlorvynol
- ethosuximide
- ethotoin
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fenoldopam
- fentanyl
- flavoxate
- flortaucipir F 18
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosinopril
- fosphenytoin
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gepirone
- glimepiride
- glipizide
- glyburide
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- heroin
- house dust mite allergen extract
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
I
- iloperidone
- iloprost
- imatinib
- imipramine
- inamrinone
- indacaterol
- indapamide
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- iobenguane I 131
- irbesartan
- irinotecan
- irinotecan liposomal
- isocarboxazid
- isoetharine
- isoniazid
- isoproterenol
- isosorbide
- isosorbide dinitrate
- isosorbide mononitrate
- isoxsuprine
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lapatinib
- larotrectinib
- lasmiditan
- lemborexant
- levalbuterol
- levamlodipine
- levetiracetam
- levmetamfetamine nasal
- levobetaxolol ophthalmic
- levobunolol ophthalmic
- levodopa
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- linezolid
- lisdexamfetamine
- lisinopril
- lithium
- liver derivative complex
- lofexidine
- lorazepam
- losartan
- loxapine
- lumateperone
- lurasidone
- lusutrombopag
M
- ma huang
- maprotiline
- maraviroc
- mazindol
- mecamylamine
- meclizine
- melatonin
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methsuximide
- methyclothiazide
- methyldopa
- methylene blue
- methylphenidate
- metipranolol ophthalmic
- metoclopramide
- metolazone
- metoprolol
- metyrosine
- midazolam
- milnacipran
- milrinone
- minoxidil
- mirtazapine
- mitotane
- mitoxantrone
- mixed grass pollens allergen extract
- moexipril
- molindone
- morphine liposomal
N
- nabilone
- nadolol
- naphazoline nasal
- naphazoline ophthalmic
- nateglinide
- nebivolol
- nefazodone
- nesiritide
- nicardipine
- nifedipine
- nimodipine
- niraparib
- nisoldipine
- nitroglycerin
- nitroprusside
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olodaterol
- opicapone
- opium
- orphenadrine
- oxazepam
- oxcarbazepine
- oxymetazoline nasal
- oxymetazoline ophthalmic
- oxymetazoline topical
- oxymorphone
- ozanimod
P
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylephrine
- phenylephrine nasal
- phenylephrine ophthalmic
- phenylephrine topical
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pirbuterol
- polythiazide
- pramipexole
- prazosin
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propiomazine
- propoxyphene
- propranolol
- propylhexedrine nasal
- protriptyline
- pseudoephedrine
- pyrilamine
Q
R
- racepinephrine
- ragweed pollen allergen extract
- ramelteon
- ramipril
- remifentanil
- remimazolam
- repaglinide
- ripretinib
- risperidone
- ritodrine
- ropinirole
- rosuvastatin
- rotigotine
- rufinamide
S
- salmeterol
- scopolamine
- secobarbital
- seladelpar
- selexipag
- sertraline
- sibutramine
- sildenafil
- silodosin
- solriamfetol
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfasalazine
- suvorexant
T
- tadalafil
- talazoparib
- tamsulosin
- tapentadol
- tasimelteon
- tedizolid
- telmisartan
- temazepam
- terazosin
- terbutaline
- teriflunomide
- tetrabenazine
- tetrahydrozoline nasal
- tetrahydrozoline ophthalmic
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- timolol
- timolol ophthalmic
- timothy grass pollen allergen extract
- tolazamide
- tolazoline
- tolbutamide
- tolcapone
- topiramate
- topotecan
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- treprostinil
- triamterene
- triazolam
- trichlormethiazide
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- tryptophan
- tyrosine
U
V
- valbenazine
- valerian
- valproic acid
- valsartan
- vardenafil
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- vortioxetine
X
Z
Safinamide alcohol/food interactions
There are 3 alcohol/food interactions with safinamide.
Safinamide disease interactions
There are 4 disease interactions with safinamide which include:
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More about safinamide
- safinamide consumer information
- Check interactions
- Compare alternatives
- Reviews (4)
- Side effects
- Dosage information
- During pregnancy
- Drug class: dopaminergic antiparkinsonism agents
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
