Opium Drug Interactions
Currently displaying a list of 416 drugs known to interact with opium.
- 26 major drug interactions
- 389 moderate drug interactions
- 1 minor drug interaction
Medications known to interact with opium
Note: Showing generic names only.
A
- acebutolol
- acetylcarbromal
- acrivastine
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- alprazolam
- alvimopan
- amifampridine
- amiloride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amyl nitrite
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- aripiprazole
- asenapine
- atenolol
- atezolizumab
- atomoxetine
- atropine
- attapulgite
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- baricitinib
- belladonna
- benazepril
- bendroflumethiazide
- benzthiazide
- benztropine
- bepridil
- betaxolol
- biperiden
- bismuth subgallate
- bismuth subsalicylate
- bisoprolol
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- candesartan
- cannabidiol
- cannabis
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- cemiplimab
- cenobamate
- cetirizine
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorthalidone
- chlorzoxazone
- cimetidine
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clozapine
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- dantrolene
- daridorexant
- darifenacin
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dicyclomine
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- divalproex sodium
- dostarlimab
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- droperidol
- duloxetine
- durvalumab
E
- efavirenz
- eluxadoline
- enalapril
- enalaprilat
- enflurane
- entacapone
- eplerenone
- eprosartan
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethosuximide
- ethotoin
- evening primrose
- ezogabine
F
- felbamate
- felodipine
- fenfluramine
- fentanyl
- fesoterodine
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- fosinopril
- fosphenytoin
- fospropofol
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- ginkgo
- glycopyrrolate
- glycopyrronium topical
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- halothane
- heroin
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyzine
- hyoscyamine
I
- ifosfamide
- iloperidone
- imipramine
- indapamide
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- irbesartan
- isocarboxazid
- isoflurane
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- lemborexant
- levamlodipine
- levetiracetam
- levocetirizine
- levodopa
- levomethadyl acetate
- levorphanol
- lidocaine
- lindane topical
- linezolid
- lisinopril
- lithium
- lofexidine
- loperamide
- lorazepam
- losartan
- loxapine
- lumateperone
- lurasidone
M
- maprotiline
- mebrofenin
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methotrimeprazine
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- metyrosine
- mibefradil
- midazolam
- minoxidil
- mirtazapine
- mitotane
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- naloxone
- naltrexone
- nebivolol
- nefazodone
- nicardipine
- nifedipine
- nimodipine
- nisoldipine
- nitroglycerin
- nitroprusside
- nitrous oxide
- nivolumab
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olopatadine nasal
- opicapone
- orphenadrine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- ozanimod
P
- paliperidone
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pegvisomant
- pembrolizumab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- phenacemide
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentolamine
- phenytoin
- pimozide
- pindolol
- polyethylene glycol 3350 with electrolytes
- polythiazide
- pramipexole
- prasugrel
- prazosin
- pregabalin
- primidone
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
Q
R
- ramelteon
- ramipril
- rasagiline
- remifentanil
- remimazolam
- retifanlimab
- risperidone
- ropeginterferon alfa-2b
- ropinirole
- rotigotine
- rufinamide
S
- safinamide
- scopolamine
- secobarbital
- selegiline
- sertraline
- sevoflurane
- sibutramine
- sildenafil
- silodosin
- sodium oxybate
- sodium polystyrene sulfonate
- sofpironium topical
- solifenacin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- suvorexant
T
- tamsulosin
- tapentadol
- tasimelteon
- tedizolid
- telmisartan
- temazepam
- terazosin
- tetrabenazine
- thalidomide
- thiethylperazine
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- timolol
- tislelizumab
- tizanidine
- tofacitinib
- tolcapone
- tolterodine
- topiramate
- toripalimab
- torsemide
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- triamterene
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- trospium
U
V
Z
Opium alcohol/food interactions
There is 1 alcohol/food interaction with opium.
Opium disease interactions
There are 16 disease interactions with opium which include:
- impaired GI motility
- infectious diarrhea
- prematurity
- acute alcohol intoxication
- drug dependence
- hypotension
- intracranial pressure
- respiratory depression
- gastrointestinal obstruction
- adrenal insufficiency
- liver disease
- renal dysfunction
- seizure disorders
- urinary retention
- arrhythmias
- biliary tract disease
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- Drug class: Opioids (narcotic analgesics)
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.