Zydelig Drug Interactions
Currently displaying a list of 901 drugs known to interact with Zydelig (idelalisib).
- 235 major drug interactions
- 647 moderate drug interactions
- 18 minor drug interactions
Medications known to interact with Zydelig
Note: Showing generic names only.
A
- abacavir
- abametapir topical
- abarelix
- abemaciclib
- abiraterone
- abrocitinib
- acalabrutinib
- acarbose
- acetaminophen
- acitretin
- adagrasib
- adalimumab
- adenovirus vaccine
- ado-trastuzumab emtansine
- afatinib
- albendazole
- aldesleukin
- alectinib
- alefacept
- alemtuzumab
- alfentanil
- alfuzosin
- aliskiren
- allogeneic processed thymus tissue
- allopurinol
- almotriptan
- alpelisib
- alprazolam
- ambrisentan
- aminoglutethimide
- aminosalicylic acid
- amiodarone
- amlodipine
- amobarbital
- amprenavir
- anakinra
- anthrax vaccine adsorbed
- apalutamide
- apixaban
- aprepitant
- aprocitentan
- aripiprazole
- armodafinil
- arsenic trioxide
- asciminib
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- astemizole
- atazanavir
- atezolizumab
- atogepant
- atomoxetine
- atorvastatin
- atovaquone
- atrasentan
- avacopan
- avanafil
- avapritinib
- avatrombopag
- avelumab
- axicabtagene ciloleucel
- axitinib
- azacitidine
- azathioprine
- azithromycin
B
- baricitinib
- bcg
- bcg vaccine
- bedaquiline
- belinostat
- belumosudil
- belzutifan
- benazepril
- bendamustine
- benzgalantamine
- bepridil
- berotralstat
- betamethasone
- bevacizumab
- bexarotene
- bicalutamide
- bifidobacterium infantis
- bifidobacterium longum
- binimetinib
- black cohosh
- blinatumomab
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brentuximab
- brewer's yeast
- brexpiprazole
- brexucabtagene autoleucel
- brigatinib
- brincidofovir
- bromfenac
- bromocriptine
- budesonide
- budesonide nasal
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- cabazitaxel
- cabozantinib
- calaspargase pegol
- canakinumab
- candida albicans extract
- cannabidiol
- cannabis
- capecitabine
- capivasertib
- capmatinib
- captopril
- carbamazepine
- carboplatin
- carfilzomib
- cariprazine
- carmustine
- caspofungin
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cerivastatin
- certolizumab
- cetuximab
- cevimeline
- chaparral
- chenodiol
- chikungunya vaccine, live (cvx 317)
- chikungunya vaccine, recombinant (cvx 329)
- chloramphenicol
- chloramphenicol ophthalmic
- chloramphenicol otic
- chloroquine
- chlorzoxazone
- cholera vaccine
- cholera vaccine, live
- ciclesonide
- ciclesonide nasal
- cilostazol
- ciltacabtagene autoleucel
- cinacalcet
- ciprofloxacin
- cisapride
- citalopram
- cladribine
- clarithromycin
- clavulanate
- clindamycin
- clofarabine
- clonazepam
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- cobimetinib
- coccidioidin skin test
- colchicine
- comfrey
- conivaptan
- copanlisib
- cortisone
- cosibelimab
- COVID-19 mRNA (Moderna) vaccine
- COVID-19 mRNA (Pfizer) vaccine
- crizotinib
- cyclosporine
- cytarabine
- cytarabine liposomal
D
- dabigatran
- dabrafenib
- dacarbazine
- daclatasvir
- daclizumab
- dacomitinib
- dactinomycin
- danazol
- danicopan
- dantrolene
- daprodustat
- daratumumab
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- decitabine
- deferasirox
- deferiprone
- deflazacort
- dehydroepiandrosterone
- delandistrogene moxeparvovec
- delavirdine
- demeclocycline
- dengue vaccine
- denileukin diftitox
- denosumab
- deucravacitinib
- dexamethasone
- dexamethasone nasal
- dexamethasone ophthalmic
- diazepam
- diclofenac
- diclofenac topical
- didanosine
- dihydroergotamine
- diltiazem
- dimethyl fumarate
- dinutuximab
- diroximel fumarate
- disopyramide
- disulfiram
- divalproex sodium
- docetaxel
- dofetilide
- dolutegravir
- donepezil
- doravirine
- dostarlimab
- doxazosin
- doxorubicin
- doxorubicin liposomal
- doxycycline
- dronedarone
- droperidol
- drospirenone
- duloxetine
- durvalumab
- dutasteride
- duvelisib
E
- echinacea
- efalizumab
- efavirenz
- efbemalenograstim alfa
- eflapegrastim
- eflornithine
- elacestrant
- elafibranor
- elagolix
- eletriptan
- eliglustat
- elotuzumab
- elranatamab
- eltrombopag
- eluxadoline
- emtricitabine
- enalapril
- enalaprilat
- enasidenib
- encorafenib
- enfortumab vedotin
- ensartinib
- entrectinib
- enzalutamide
- epirubicin
- eplerenone
- eravacycline
- erdafitinib
- ergonovine
- ergotamine
- eribulin
- erlotinib
- erythromycin
- escitalopram
- eslicarbazepine
- estazolam
- eszopiclone
- etanercept
- ethambutol
- ethanol
- ethionamide
- ethosuximide
- ethotoin
- etodolac
- etoposide
- etranacogene dezaparvovec
- etrasimod
- etravirine
- etretinate
- everolimus
F
- fam-trastuzumab deruxtecan
- febuxostat
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenofibric acid
- fenoprofen
- fentanyl
- fesoterodine
- fexinidazole
- fezolinetant
- fidanacogene elaparvovec
- filgrastim
- finerenone
- fingolimod
- fitusiran
- flibanserin
- floxuridine
- fluconazole
- fludarabine
- fludrocortisone
- flunisolide
- flunisolide nasal
- fluorometholone ophthalmic
- fluorouracil
- fluoxymesterone
- flurazepam
- flurbiprofen
- flutamide
- fluticasone
- fluticasone nasal
- fluvastatin
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fostamatinib
- fostemsavir
- fruquintinib
- futibatinib
G
- galantamine
- ganaxolone
- ganciclovir
- gefitinib
- gemcitabine
- gemtuzumab
- gepirone
- gilteritinib
- givinostat
- givosiran
- glasdegib
- golimumab
- goserelin
- granisetron
- grepafloxacin
- griseofulvin
- guanfacine
H
- haemophilus b conjugate (hboc) vaccine
- haemophilus b conjugate (prp-omp) vaccine
- haemophilus b conjugate (prp-t) vaccine
- halofantrine
- haloperidol
- halothane
- hepatitis a adult vaccine
- hepatitis a pediatric vaccine
- hepatitis b adult vaccine
- hepatitis b pediatric vaccine
- histoplasmin
- human papillomavirus vaccine
- hydrocodone
- hydrocortisone
- hydroxychloroquine
I
- ibrexafungerp
- ibritumomab
- ibrutinib
- ibuprofen
- idarubicin
- idecabtagene vicleucel
- iloperidone
- imatinib
- inavolisib
- indacaterol
- indinavir
- indomethacin
- infigratinib
- infliximab
- influenza virus vaccine, h1n1, inactivated
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, h5n1
- influenza virus vaccine, inactivated
- influenza virus vaccine, live
- inotersen
- inotuzumab ozogamicin
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- iobenguane I 131
- iodine i 131 tositumomab
- ipilimumab
- iptacopan
- irinotecan
- irinotecan liposomal
- isatuximab
- isavuconazonium
- isoniazid
- isotretinoin
- isradipine
- istradefylline
- itraconazole
- ivabradine
- ivacaftor
- ivermectin
- ivosidenib
- ixabepilone
- ixazomib
J
K
L
- labetalol
- lacosamide
- lactobacillus acidophilus
- lactobacillus reuteri
- lactobacillus rhamnosus
- lactobacillus rhamnosus gg
- lamivudine
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- leflunomide
- lemborexant
- lenacapavir
- lenalidomide
- leniolisib
- lenvatinib
- letermovir
- letrozole
- levacetylleucine
- levamlodipine
- levobupivacaine
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- lidocaine
- linaclotide
- lisinopril
- lisocabtagene maraleucel
- lomitapide
- lomustine
- lonafarnib
- lonapegsomatropin
- loncastuximab tesirine
- loperamide
- loratadine
- lorlatinib
- loteprednol ophthalmic
- lovastatin
- lubiprostone
- lumateperone
- lurasidone
- lurbinectedin
- lusutrombopag
- lutetium lu 177 dotatate
- lyme disease vaccine
M
- macitentan
- maralixibat
- maraviroc
- maribavir
- mavacamten
- mavorixafor
- measles virus vaccine
- meclofenamate
- mefenamic acid
- mefloquine
- meloxicam
- meningococcal conjugate vaccine
- meningococcal group acwy conjugate-group b vaccine (cvx 316)
- meningococcal group acwy conjugate-group b vaccine (cvx 328)
- meningococcal group B vaccine
- meningococcal polysaccharide vaccine
- mephenytoin
- mephobarbital
- mercaptopurine
- metaxalone
- methadone
- methimazole
- methotrexate
- methyldopa
- methylergonovine
- methylprednisolone
- methyltestosterone
- methysergide maleate
- metreleptin
- mibefradil
- midazolam
- midostaurin
- mifepristone
- milnacipran
- miltefosine
- minocycline
- mipomersen
- mirabegron
- mirikizumab
- mirtazapine
- mirvetuximab soravtansine
- mitapivat
- mitotane
- mitoxantrone
- mixed respiratory vaccine
- mobocertinib
- modafinil
- moexipril
- mogamulizumab
- momelotinib
- mometasone
- mometasone nasal
- monomethyl fumarate
- moxifloxacin
- mumps skin test antigen
- mumps virus vaccine
N
- nabumetone
- nadofaragene firadenovec
- nafcillin
- naldemedine
- naloxegol
- naltrexone
- nandrolone
- naproxen
- natalizumab
- necitumumab
- nefazodone
- nelarabine
- nelfinavir
- neratinib
- nevirapine
- niacin
- niacinamide
- nicardipine
- nicotinamide
- nifedipine
- nilotinib
- nilutamide
- nimodipine
- nintedanib
- niraparib
- nirogacestat
- nisoldipine
- nitisinone
- nitrofurantoin
- nivolumab
O
- obecabtagene autoleucel
- obinutuzumab
- ocrelizumab
- odevixibat
- olaparib
- oliceridine
- olutasidenib
- omacetaxine
- omaveloxolone
- onasemnogene abeparvovec
- ondansetron
- oritavancin
- orlistat
- osilodrostat
- osimertinib
- ospemifene
- oxaliplatin
- oxandrolone
- oxaprozin
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymetholone
- oxytetracycline
- ozanimod
P
- paclitaxel
- paclitaxel protein-bound
- pacritinib
- palbociclib
- palovarotene
- panitumumab
- panobinostat
- paricalcitol
- pasireotide
- pazopanib
- pegaspargase
- pegfilgrastim
- peginterferon alfa-2a
- peginterferon alfa-2b
- peginterferon beta-1a
- pembrolizumab
- pemetrexed
- pemigatinib
- pemoline
- pennyroyal
- penpulimab
- pentobarbital
- pentostatin
- perindopril
- pertussis, acellular
- pertuzumab
- pexidartinib
- phenazopyridine
- phenobarbital
- phenylbutazone
- phenytoin
- pimavanserin
- pimecrolimus topical
- pimozide
- pioglitazone
- pirfenidone
- piroxicam
- pirtobrutinib
- pitavastatin
- plague vaccine
- plecanatide
- plicamycin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 23-polyvalent vaccine
- pneumococcal 7-valent vaccine
- polatuzumab vedotin
- poliovirus vaccine, inactivated
- poliovirus vaccine, live, trivalent
- pomalidomide
- ponatinib
- ponesimod
- posaconazole
- pralatrexate
- pralsetinib
- pravastatin
- praziquantel
- prednisolone
- prednisolone ophthalmic
- prednisone
- pretomanid
- primidone
- propafenone
- propylthiouracil
- prucalopride
- pseudoephedrine
- pyrazinamide
Q
R
- rabies vaccine, human diploid cell
- rabies vaccine, purified chick embryo cell
- ramelteon
- ramipril
- ramucirumab
- ranolazine
- rasburicase
- red yeast rice
- regorafenib
- remdesivir
- repaglinide
- repotrectinib
- resmetirom
- retapamulin topical
- retifanlimab
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- rilpivirine
- riluzole
- rimegepant
- riociguat
- ripretinib
- ritlecitinib
- ritonavir
- rivaroxaban
- rofecoxib
- roflumilast topical
- romidepsin
- ropeginterferon alfa-2b
- ropivacaine
- rosiglitazone
- rosuvastatin
- rotavirus vaccine
- rsv vaccine pref3, recombinant
- rsv vaccine, mrna
- rsv vaccine, pref a-pref b, recombinant
- rubella virus vaccine
- rucaparib
- rufinamide
- ruxolitinib
- ruxolitinib topical
S
- saccharomyces boulardii lyo
- sacituzumab govitecan
- salmeterol
- samarium sm 153 lexidronam
- saquinavir
- sarecycline
- sargramostim
- sarilumab
- sars-cov-2 (covid-19) ad26 vaccine, recombinant
- sars-cov-2 (covid-19) chadox1 vaccine, recombinant
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 308)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 309)
- sars-cov-2 (covid-19) mrna-lnp vaccine (cvx 310)
- sars-cov-2 (covid-19) nvx-cov2373 vaccine, recombinant
- sars-cov-2 (covid-19) nvx-cov2705 vaccine, adjuvanted
- sars-cov-2 (covid-19) rs-nanoparticle vaccine, recombinant
- sars-cov-2 mrna (tozinameran 5y-11y) vaccine
- sars-cov-2 mrna (tozinameran 6m-4y) vaccine
- sars-cov-2 mrna (tozinameran-tris-sucrose) vaccine
- sars-cov-2 mrna (tozinameran) vaccine
- sars-cov-2 mrna-1273 (6m-5y) vaccine
- sars-cov-2 mrna-1273 (6y-11y) vaccine
- sars-cov-2 mrna-1273 (booster only) vaccine
- sars-cov-2 nvx-cov2373 vaccine, recomb (cvx 313)
- sars-cov-2 pres dtm (booster only) vaccine, recombinant
- satralizumab
- saxagliptin
- secobarbital
- seladelpar
- selexipag
- selinexor
- selpercatinib
- selumetinib
- sibutramine
- sildenafil
- silodosin
- simvastatin
- siponimod
- sipuleucel-T
- sirolimus
- sirolimus protein-bound
- sirolimus topical
- skin test antigens, multiple
- smallpox and mpox vaccine
- smallpox vaccine
- sodium phosphate p32
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sonidegib
- sorafenib
- sotorasib
- sparsentan
- st. john's wort
- stanozolol
- staphage lysate (spl)
- stavudine
- stiripentol
- streptococcus salivarius
- strontium-89 chloride
- sufentanil
- sulfadiazine
- sulfadoxine
- sulfamethizole
- sulfamethoxazole
- sulfasalazine
- sulfinpyrazone
- sulfisoxazole
- sulindac
- sunitinib
- suvorexant
- suzetrigine
T
- tacrine
- tacrolimus
- tacrolimus topical
- tadalafil
- tafasitamab
- tagraxofusp
- talazoparib
- taletrectinib
- talimogene laherparepvec
- talquetamab
- tamoxifen
- tamsulosin
- tarlatamab
- tasimelteon
- tazemetostat
- tbo-filgrastim
- teclistamab
- tecovirimat
- telaprevir
- telisotuzumab vedotin
- telithromycin
- telotristat
- temozolomide
- temsirolimus
- teniposide
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terbinafine
- terfenadine
- teriflunomide
- testosterone
- testosterone topical
- tetanus toxoid
- tetracycline
- thioguanine
- thiotepa
- tiagabine
- ticagrelor
- tick-borne encephalitis (inactivated) pediatric vaccine
- tick-borne encephalitis (inactivated) vaccine
- tinidazole
- tipranavir
- tisagenlecleucel
- tislelizumab
- tisotumab vedotin
- tizanidine
- tocilizumab
- tofacitinib
- tolcapone
- tolmetin
- tolterodine
- tolvaptan
- topotecan
- toremifene
- toripalimab
- tositumomab
- tovorafenib
- trabectedin
- tramadol
- trametinib
- trandolapril
- trastuzumab
- trazodone
- tremelimumab
- treosulfan
- tretinoin
- triamcinolone
- triamcinolone nasal
- triamcinolone ophthalmic
- triazolam
- trichophyton skin test
- trimetrexate
- trofinetide
- troglitazone
- troleandomycin
- trovafloxacin
- tuberculin purified protein derivative
- tucatinib
- typhoid vaccine, inactivated
- typhoid vaccine, live
U
V
- vadadustat
- valbenazine
- valdecoxib
- valganciclovir
- valoctocogene roxaparvovec
- valproic acid
- vamorolone
- vandetanib
- vardenafil
- varicella virus vaccine
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vibegron
- vilazodone
- viloxazine
- vimseltinib
- vinblastine
- vincristine
- vincristine liposome
- vinorelbine
- vismodegib
- voclosporin
- vonoprazan
- vorapaxar
- vorasidenib
- voriconazole
- vorinostat
- voxelotor
W
Y
Z
- zafirlukast
- zalcitabine
- zanidatamab
- zanubrutinib
- zidovudine
- zileuton
- ziprasidone
- ziv-aflibercept
- zolbetuximab
- zolpidem
- zonisamide
- zoster vaccine live
- zoster vaccine, recombinant
- zuranolone
Zydelig alcohol/food interactions
There is 1 alcohol/food interaction with Zydelig (idelalisib).
Zydelig disease interactions
There are 7 disease interactions with Zydelig (idelalisib) which include:
- colitis
- dermatologic toxicities
- hepatic impairment
- infections
- intestinal perforation
- neutropenia
- lung toxicity
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- FDA approval history
- Drug class: PI3K inhibitors
- Breastfeeding
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Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
