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Zydelig Side Effects

Generic Name: idelalisib

Note: This page contains side effects data for the generic drug idelalisib. It is possible that some of the dosage forms included below may not apply to the brand name Zydelig.

In Summary

Common side effects of Zydelig include: hepatotoxicity, pneumonitis, severe colitis, severe diarrhea, exfoliative dermatitis, pneumonia, colitis, abdominal pain, cough, dyspnea, erythematous rash, fever, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, macular eruption, maculopapular rash, nausea, neutropenia, pruritic rash, skin rash, and vomiting. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to idelalisib: oral tablet

As well as its needed effects, idelalisib (the active ingredient contained in Zydelig) may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking idelalisib, check with your doctor immediately:

More common:
  • Abdominal or stomach pain or tenderness
  • black, tarry stools
  • body aches or pain
  • chills
  • clay colored stools
  • confusion
  • cough
  • cough producing mucus
  • dark urine
  • decreased appetite
  • difficulty with breathing
  • dizziness
  • ear congestion
  • fainting
  • fast heartbeat
  • fever
  • headache
  • itching or skin rash
  • lightheadedness
  • loss of appetite
  • loss of voice
  • lower back or side pain
  • nausea and vomiting
  • pain
  • pain or tenderness around the eyes and cheekbones
  • painful or difficult urination
  • pale skin
  • rapid, shallow breathing
  • sneezing
  • sore throat
  • stomach cramps
  • stuffy or runny nose
  • swelling of the feet or lower legs
  • tightness in the chest
  • troubled breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • watery or bloody diarrhea
  • yellow eyes or skin
Less common:
  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain
Incidence not known:
  • Blistering, peeling, or loosening of the skin
  • chest pain
  • cracks in the skin
  • difficulty with swallowing
  • general feeling of discomfort or illness
  • heartburn
  • hives
  • indigestion
  • joint or muscle pain
  • loss of heat from the body
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • scaly skin
  • severe abdominal or stomach pain, cramping, or burning
  • thickening of bronchial secretions
  • vomiting of material that looks like coffee grounds, severe and continuing

Minor Side Effects

Some idelalisib side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

More common:
  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased appetite
  • difficulty with moving
  • muscle pain or stiffness
  • night sweats
  • pain in the joints
  • rapid weight gain
  • tingling of the hands or feet
  • trouble sleeping
  • unusual weight gain or loss

For Healthcare Professionals

Applies to idelalisib: oral tablet

General

The most commonly occurring adverse reactions were pneumonia, pyrexia, sepsis, febrile neutropenia, cough, abdominal pain, chills, rash, fatigue, and diarrhea.[Ref]

Hepatic

Very common (10% or more): Increased ALT (up to 50%), increased AST (up to 41%), increased GGT (up to 26%)[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (up to 47%), nausea (up to 29%), abdominal pain (up to 26%), vomiting (up to 15%)
Common (1% to 10%): Gastroesophageal reflux disease, stomatitis[Ref]

Respiratory

Very common (10% or more): Cough (up to 29%), pneumonia (up to 25%), dyspnea (up to 17%), upper respiratory tract infection (up to 12%)
Common (1% to 10%): Nasal congestion[Ref]

Hematologic

Very common (10% or more): Decreased neutrophils (up to 60%), decreased hemoglobin (up to 28%), decreased platelets (up to 26%), increased lymphocytes (up to 25%), decreased lymphocytes (up to 20%)[Ref]

Metabolic

Very common (10% or more): Hypertriglyceridemia (up to 56%), hyperglycemia (up to 54%), hyponatremia (up to 20%), decreased appetite (up to 16%), hypoglycemia (up to 11%)[Ref]

Other

Very common (10% or more): Pyrexia (up to 35%), fatigue (up to 30%), chills (up to 21%), asthenia (up to 12%), peripheral edema (up to 10%)
Common (1% to 10%): Pain[Ref]

Immunologic

Common (1% to 10%): Sepsis, bronchitis, sinusitis, urinary tract infection[Ref]

Dermatologic

Very common (10% or more): Rash (up to 21%), night sweats (up to 12%)[Ref]

Musculoskeletal

Common (1% to 10%): Arthralgia[Ref]

Nervous system

Very common (10% or more): Headache (up to 11%)[Ref]

Psychiatric

Very common (10% or more): Insomnia (up to 12%)[Ref]

References

1. "Product Information. Zydelig (idelalisib)." Gilead Sciences, Foster City, CA.

It is possible that some side effects of Zydelig may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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