Motrin PM Interactions
There are 759 drugs known to interact with Motrin PM (diphenhydramine/ibuprofen), along with 19 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 114 are major, 631 are moderate, and 14 are minor.
- View all 759 medications that may interact with Motrin PM
- View Motrin PM alcohol/food interactions (2)
- View Motrin PM disease interactions (19)
Most frequently checked interactions
View interaction reports for Motrin PM (diphenhydramine / ibuprofen) and the medicines listed below.
- alprazolam
- alprazolam
- aspirin
- aspirin
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- clonazepam
- clonazepam
- cyclobenzaprine
- cyclobenzaprine
- gabapentin
- gabapentin
- hydrochlorothiazide
- hydrochlorothiazide
- ibuprofen
- ibuprofen
- melatonin
- melatonin
- metformin
- metformin
- omeprazole
- omeprazole
- tramadol
- tramadol
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin D3 (cholecalciferol)
- Vitamin D3 (cholecalciferol)
- Xanax (alprazolam)
- Xanax (alprazolam)
Motrin PM alcohol/food interactions
There are 2 alcohol/food interactions with Motrin PM (diphenhydramine / ibuprofen).
Motrin PM disease interactions
There are 19 disease interactions with Motrin PM (diphenhydramine / ibuprofen) which include:
- depression
- asthma
- fluid retention
- GI toxicity
- rash
- renal toxicities
- thrombosis
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- PKU
- anemia
- hepatotoxicity
- hyperkalemia
- platelet aggregation inhibition
Report options
More about Motrin PM (diphenhydramine / ibuprofen)
- Motrin PM consumer information
- Compare alternatives
- Drug images
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Naproxen
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Botox
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Hydroxyzine
Hydroxyzine is an antihistamine used to treat itching, hives, and anxiety. It also acts as a ...
Tramadol
Tramadol is an opioid medication that may be used to treat moderate to moderately severe chronic ...
Cyclobenzaprine
Cyclobenzaprine is a muscle relaxant and works by blocking pain sensations. Includes ...
Meloxicam
Meloxicam is a nonsteroidal anti-inflammatory drug used to treat pain or inflammation caused by ...
Aspirin
Aspirin is used to treat mild to moderate pain and to reduce fever or inflammation. Learn about ...
Oxycodone
Oxycodone is an opioid analgesic used to treat moderate to severe pain; it has a high potential for ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
