Skip to Content

Motrin PM (diphenhydramine / ibuprofen) Drug Interactions

A total of 1083 drugs (5967 brand and generic names) are known to interact with Motrin PM (diphenhydramine / ibuprofen).

  • 138 major drug interactions (646 brand and generic names)
  • 919 moderate drug interactions (5152 brand and generic names)
  • 26 minor drug interactions (169 brand and generic names)

Show all medications in the database that may interact with Motrin PM (diphenhydramine / ibuprofen).

Check for interactions with Motrin PM (diphenhydramine / ibuprofen)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Motrin PM (diphenhydramine / ibuprofen)

Motrin PM (diphenhydramine / ibuprofen) alcohol/food Interactions

There are 3 alcohol/food interactions with Motrin PM (diphenhydramine / ibuprofen)

Motrin PM (diphenhydramine / ibuprofen) disease Interactions

There are 21 disease interactions with Motrin PM (diphenhydramine / ibuprofen) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2017 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.