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Diphenhydramine / guaifenesin Drug Interactions

A total of 826 drugs are known to interact with diphenhydramine / guaifenesin.

  • 33 major drug interactions
  • 789 moderate drug interactions
  • 4 minor drug interactions

Show all medications in the database that may interact with diphenhydramine / guaifenesin.

Check for interactions with diphenhydramine / guaifenesin

Type in a drug name and select a drug from the list.

Common medications checked in combination with diphenhydramine / guaifenesin

  • Adderall (amphetamine / dextroamphetamine)
  • Afrin (oxymetazoline nasal)
  • Aspirin Low Strength (aspirin)
  • Centrum Singles-Beta Carotene (beta-carotene)
  • Clomid (clomiphene)
  • Concerta (methylphenidate)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Unisom SleepGels, Dicopanol, Sleep, Diphenhist, Sominex, Diphen, Diphenadryl, Benadryl Children's Allergy, Allermax, Diphenydramine Quick Melt, Nytol, Diphedryl, Hydramine, Diphendryl, Pharbedryl, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen Cough, DPH, Allergia-C, Q-Dryl, Sleep Tabs, Quenalin, Sleep-ettes D, Q-Dryl A/F, Dytan, Vanamine PD, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, 40 Winks, Diphen AF, Aler-Dryl, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Diphenyl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Dormin, Miles Nervine, Scot-Tussin Allergy)
  • diphenhydramine / phenylephrine (Delsym Children's Night Time Cough & Cold, Children's Triacting Night Time, Triaminic Night Time Cold & Cough, PediaCare Nighttime Multi-Symptom Cold, Sudafed PE Nighttime Nasal Decongestant, Diphentann-D, Uni-Tann D, Aldex-CT, Diphenmax D, Triaminic Thin Strips Night Time Cold & Cough, Dimetapp Children's Nighttime Cold & Congestion, Theraflu Thin Strips Nighttime Cold and Cough, Benadryl Children's Allergy Plus Congestion, Robitussin Night Time Cough & Cold, Alahist LQ, Dytan-D, Pediatex-CT, D-Tann, Benadryl-D Allergy Plus Sinus, Benadryl-D Children's Allergy & Sinus, PediaCare Children's Allergy & Cold)
  • Folic Acid XTRA (multivitamin)
  • GenRx Tramadol (tramadol)
  • guaifenesin (Mucinex, Robitussin Chest Congestion, Robafen, Tussin, Guaifenesin LA, Guaiatussin, Humibid, Guiatuss, Guaifenex LA, Tussin Expectorant, Mucus Relief, Diabetic Expectorant, Siltussin, Sorbutuss, Humibid E, Refenesen Chest Congestion Relief, Organ-1 NR, Breonesin, Diabetic Tuss, Benylin E, Balminil Expectorant, Tixylix Chesty Cough, Xpect, Bidex-400, Strepsils Chesty Cough, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Ganidin NR, Iofen-NF, Humibid Pediatric, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Fenex-LA, Fenesin, Muco-Fen LA, Liquibid, Muco-Fen 800, Scot-Tussin Expectorant, Humavent LA, Guiacough, Lotussin, GG 200 NR, Glytuss, Altarussin, Anti-Tuss, Allfen Jr, Genatuss, Halotussin, Mastussin, Mytussin, Q-Tussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Robitussin Mucus + Chest Congestion, Naldecon-EX Senior, Phanasin, Guaifenex G, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Kenkay Chesty Cough Eexpectorant, Pharmacist Expectorant, Dristan Chesty Cough Guaiphenesin, Mucinex for Kids, Guaifen NR, Buckley's Chest Congestion, Liquituss GG, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Siltussin DAS, Diabetic Tussin Mucus Relief, Bronchoril, Hytuss, Organidin NR, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power, Mucinex Maximum Strength)
  • Januvia (sitagliptin)
  • Lipofen (fenofibrate)
  • Nexium (esomeprazole)
  • Pepto-Bismol (bismuth subsalicylate)
  • Prenatal 19 (multivitamin, prenatal)
  • Prenatal Multivitamins (multivitamin, prenatal)
  • Prevacid (lansoprazole)
  • Pyridium (phenazopyridine)
  • QNASL (beclomethasone nasal)
  • Ultram ER (tramadol)
  • Vitamin B Complex 100 (multivitamin)
  • Zoloft (sertraline)

Diphenhydramine / guaifenesin alcohol/food interactions

There is 1 alcohol/food interaction with diphenhydramine / guaifenesin

Diphenhydramine / guaifenesin disease interactions

There are 8 disease interactions with diphenhydramine / guaifenesin which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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