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Diphenhydramine / guaifenesin Drug Interactions

A total of 829 drugs are known to interact with diphenhydramine / guaifenesin.

  • 33 major drug interactions
  • 791 moderate drug interactions
  • 5 minor drug interactions

Show all medications in the database that may interact with diphenhydramine / guaifenesin.

Check for interactions

Type in a drug name to check for interactions with diphenhydramine / guaifenesin.

Most frequently checked interactions

View interaction reports for diphenhydramine / guaifenesin and the medicines listed below.

  • Adderall (amphetamine / dextroamphetamine)
  • Afrin (oxymetazoline nasal)
  • Aspirin Low Strength (aspirin)
  • Centrum Singles-Beta Carotene (beta-carotene)
  • Clomid (clomiphene)
  • Concerta (methylphenidate)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Benadryl Children's Allergy, Sominex, Dicopanol, Diphen, Sleep Tabs, Simply Sleep, Diphedryl, Diphenadryl, Quenalin, Diphenyl, Hydramine, Diphenydramine Quick Melt, Unisom SleepMelts, Nytol, Dormin, Sleepwell 2-nite, Diphenhist, 40 Winks, Diphen Cough, DPH, Calm-Aid, Sleep Tab II, Altaryl, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • diphenhydramine / phenylephrine (Dimetapp Children's Nighttime Cold & Congestion, Triaminic Night Time Cold & Cough, Delsym Children's Night Time Cough & Cold, Diphentann-D, Benadryl-D Allergy Plus Sinus, Benadryl-D Children's Allergy & Sinus, PediaCare Nighttime Multi-Symptom Cold, Sudafed PE Nighttime Nasal Decongestant, Uni-Tann D, Aldex-CT, Diphenmax D, Triaminic Thin Strips Night Time Cold & Cough, Children's Triacting Night Time, Theraflu Thin Strips Nighttime Cold and Cough, Benadryl Children's Allergy Plus Congestion, Robitussin Night Time Cough & Cold, Alahist LQ, Dytan-D, Pediatex-CT, D-Tann, PediaCare Children's Allergy & Cold)
  • Folic Acid XTRA (multivitamin)
  • GenRx Tramadol (tramadol)
  • guaifenesin (Mucinex, Robafen, Robitussin Chest Congestion, Tussin, Humibid, Tussin Expectorant, Guiatuss, Sorbutuss, Mucinex Maximum Strength, Guaiatussin, Mucus Relief, Diabetic Tussin Mucus Relief, Altarussin, Q-Tussin, Siltussin, Balminil Expectorant, Dristan Chesty Cough Guaiphenesin, Ganidin NR, Fenesin, Scot-Tussin Expectorant, Guaifenesin LA, Humavent LA, Lotussin, Robitussin Mucus + Chest Congestion, Guaifenex G, Benylin E, Mucinex for Kids, Buckley's Chest Congestion, Refenesen Chest Congestion Relief, Organidin NR, Benadryl Chesty Forte, G Bid, Touro EX, Pneumomist, Iofen-NF, Humibid Pediatric, Organ-1 NR, Iodrol NR, Mucinex Children's Chest Congestion, Guaibid-LA, Aquamist, Q-Bid LA, Amibid LA, Mucobid-LA, Guaifenex LA, Fenex-LA, Muco-Fen LA, Liquibid, Muco-Fen 800, Breonesin, Guiacough, GG 200 NR, Glytuss, Anti-Tuss, Diabetic Expectorant, Allfen Jr, Genatuss, Halotussin, Mastussin, Mytussin, Ri-Tussin, Robichem, Siltuss DAS, T-Tussin, Tusscidin, Gua-SR, Humigen LA, Sinumist, Altorant, Duratuss G, Diabetic Tuss, Naldecon-EX Senior, Phanasin, Iophen NR, GG-Cen, Muco-Fen 1200, Liquidbid LA, Liquidbid 1200, Calmylin Expectorant, Guiadrine G-1200, Siltussin DAS-NA, Iofen, Muco-Fen, Drituss G, Beechams Veno's for Kids Chesty Cough, Junior Meltus Colour and Sugar Free Expectorant, Help I Have Chest Congestion, Tixylix Chesty Cough, Xpect, Bidex-400, Humibid E, Fenesin IR, Hill's Balsam Chesty Cough, Jackson's Extra Strength All Fours, Junior Meltus Chesty Coughs with Catarrh, Liqufruta Garlic Cough Medicine, Family Meltus Chesty Coughs, Jackson's The Original All Fours, Beechams Veno's Expectorant, Lemsip Cough Chesty, Respa-GF, Nirolex Chesty Cough, Dristan Chesty Cough, Nyal Chesty Cough, Strepsils Chesty Cough, Kenkay Chesty Cough Eexpectorant, Pharmacist Expectorant, Guaifen NR, Liquituss GG, Lloydspharmacy Expectorant Adult Cough, Lloydspharmacy Expectorant Junior Cough, TabTussin 400, Siltussin DAS, Bronchoril, Hytuss, Actifed CC Chesty Cough, Mucaplex, Tussin Mucus + Chest Congestion, Air Power)
  • Januvia (sitagliptin)
  • Lipofen (fenofibrate)
  • Nexium (esomeprazole)
  • Pepto-Bismol (bismuth subsalicylate)
  • Prenatal 19 (multivitamin, prenatal)
  • Prenatal Multivitamins (multivitamin, prenatal)
  • Prevacid (lansoprazole)
  • Pyridium (phenazopyridine)
  • QNASL (beclomethasone nasal)
  • Ultram ER (tramadol)
  • Vitamin B Complex 100 (multivitamin)
  • Zoloft (sertraline)

Diphenhydramine / guaifenesin alcohol/food interactions

There is 1 alcohol/food interaction with diphenhydramine / guaifenesin

Diphenhydramine / guaifenesin disease interactions

There are 8 disease interactions with diphenhydramine / guaifenesin which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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