Diphenhydramine/guaifenesin Interactions
There are 449 drugs known to interact with diphenhydramine/guaifenesin, along with 8 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 15 are major, 431 are moderate, and 3 are minor.
- View all 449 medications that may interact with diphenhydramine/guaifenesin
- View diphenhydramine/guaifenesin alcohol/food interactions (1)
- View diphenhydramine/guaifenesin disease interactions (8)
Most frequently checked interactions
View interaction reports for diphenhydramine / guaifenesin and the medicines listed below.
- Adderall (amphetamine / dextroamphetamine)
- Advil Dual Action (acetaminophen / ibuprofen)
- Afrin (oxymetazoline nasal)
- Aleve (naproxen)
- Alka-Seltzer Extra Strength (aspirin/citric acid/sodium bicarbonate)
- Aspirin Low Strength (aspirin)
- Calcium 600 D (calcium / vitamin d)
- Centrum Silver Men's (multivitamin with minerals)
- Centrum Singles-Beta Carotene (beta-carotene)
- Clomid (clomiphene)
- Colace (docusate)
- Concerta (methylphenidate)
- CoQ10 (ubiquinone)
- Depo Provera (medroxyprogesterone)
- Estradiol Patch (estradiol)
- Folic Acid XTRA (multivitamin)
- Gaviscon Regular Strength Liquid (aluminum hydroxide / magnesium carbonate)
- GenRx Tramadol (tramadol)
- Ingrezza (valbenazine)
- Iron Sulfate (ferrous sulfate)
- Januvia (sitagliptin)
- Levothyrox (levothyroxine)
- Lipofen (fenofibrate)
- Loratadine Reditab (loratadine)
- Mucinex DM (dextromethorphan / guaifenesin)
- Multivitamins and Minerals (multivitamin with minerals)
- Nexium (esomeprazole)
- Vitamin B1 (thiamine)
- Vitamin B12 (cyanocobalamin)
- Vyvanse (lisdexamfetamine)
Diphenhydramine/guaifenesin alcohol/food interactions
There is 1 alcohol/food interaction with diphenhydramine / guaifenesin.
Diphenhydramine/guaifenesin disease interactions
There are 8 disease interactions with diphenhydramine / guaifenesin which include:
- depression
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
Report options
More about diphenhydramine / guaifenesin
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.