Epidiolex Drug Interactions
Currently displaying a list of 619 drugs known to interact with Epidiolex (cannabidiol).
- 19 major drug interactions
- 545 moderate drug interactions
- 55 minor drug interactions
Medications known to interact with Epidiolex
Note: Showing generic names only.
A
- abacavir
- abemaciclib
- abiraterone
- acarbose
- acetaminophen
- acetylcarbromal
- acitretin
- acrivastine
- adagrasib
- ado-trastuzumab emtansine
- afatinib
- aldesleukin
- alectinib
- alfentanil
- allopurinol
- alprazolam
- ambrisentan
- aminophylline
- aminosalicylic acid
- amiodarone
- amitriptyline
- amobarbital
- amoxapine
- amprenavir
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- aprocitentan
- aripiprazole
- asciminib
- asenapine
- ashwaganda
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atomoxetine
- atorvastatin
- atovaquone
- atrasentan
- avacopan
- axitinib
- azatadine
- azelastine nasal
- azithromycin
B
- baclofen
- bedaquiline
- belinostat
- belumosudil
- belzutifan
- benazepril
- benztropine
- berotralstat
- bexarotene
- bicalutamide
- binimetinib
- biperiden
- black cohosh
- blinatumomab
- boceprevir
- bortezomib
- bosentan
- bosutinib
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromfenac
- bromocriptine
- brompheniramine
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- calaspargase pegol
- cannabis
- capmatinib
- captopril
- carbamazepine
- carbetapentane
- carbinoxamine
- carfilzomib
- cariprazine
- carisoprodol
- carmustine
- caspofungin
- celecoxib
- cenobamate
- ceritinib
- cerivastatin
- cetirizine
- chaparral
- chenodiol
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- ciprofloxacin
- citalopram
- clarithromycin
- clavulanate
- clemastine
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- cobimetinib
- codeine
- colchicine
- comfrey
- conivaptan
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclosporine
- cyproheptadine
- cytarabine
D
- dacarbazine
- daclizumab
- danazol
- danicopan
- dantrolene
- daridorexant
- darunavir
- deferasirox
- dehydroepiandrosterone
- delandistrogene moxeparvovec
- delavirdine
- desipramine
- desvenlafaxine
- deucravacitinib
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- diclofenac
- diclofenac topical
- didanosine
- difelikefalin
- diltiazem
- dimenhydrinate
- dimethyl fumarate
- diphenhydramine
- diroximel fumarate
- divalproex sodium
- dolutegravir
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- duvelisib
E
- efavirenz
- eflornithine
- elagolix
- elotuzumab
- elranatamab
- eltrombopag
- emtricitabine
- enalapril
- enalaprilat
- encorafenib
- entacapone
- entrectinib
- enzalutamide
- epirubicin
- erlotinib
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- esomeprazole
- estazolam
- eszopiclone
- ethambutol
- ethanol
- ethchlorvynol
- ethionamide
- ethosuximide
- ethotoin
- etodolac
- etranacogene dezaparvovec
- etrasimod
- etretinate
- evening primrose
- everolimus
- ezogabine
F
- febuxostat
- fedratinib
- felbamate
- fenfluramine
- fenofibrate
- fenofibric acid
- fenoprofen
- fentanyl
- fexinidazole
- fezolinetant
- fidanacogene elaparvovec
- fingolimod
- fitusiran
- flavoxate
- flibanserin
- fluconazole
- fluoxetine
- fluoxymesterone
- fluphenazine
- flurazepam
- flurbiprofen
- flutamide
- fluvastatin
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosinopril
- fosphenytoin
- fostamatinib
- fruquintinib
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gefitinib
- gemcitabine
- gemtuzumab
- gilteritinib
- ginkgo
- givosiran
H
I
- ibuprofen
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indinavir
- indomethacin
- infliximab
- inotersen
- inotuzumab ozogamicin
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- ipilimumab
- isavuconazonium
- isocarboxazid
- isoniazid
- isotretinoin
- itraconazole
- ivacaftor
- ixazomib
K
L
- labetalol
- lamivudine
- lamotrigine
- lansoprazole
- lapatinib
- larotrectinib
- lasmiditan
- lefamulin
- leflunomide
- lemborexant
- lenacapavir
- lenalidomide
- lenvatinib
- letermovir
- letrozole
- levetiracetam
- levocetirizine
- levodopa
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levorphanol
- lidocaine
- lisinopril
- lithium
- lofexidine
- lomitapide
- lomustine
- lonafarnib
- lorazepam
- lovastatin
- loxapine
- lumateperone
- lurasidone
- lurbinectedin
- lutetium lu 177 dotatate
M
- macitentan
- maprotiline
- maralixibat
- maraviroc
- mavacamten
- mavorixafor
- meclizine
- meclofenamate
- mefenamic acid
- mefloquine
- melatonin
- meloxicam
- meperidine
- mephenytoin
- mephobarbital
- meprobamate
- mercaptopurine
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methimazole
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methsuximide
- methyldopa
- methyltestosterone
- metoclopramide
- metyrosine
- mibefradil
- midazolam
- mifepristone
- milnacipran
- minocycline
- mipomersen
- mirikizumab
- mirtazapine
- mitotane
- moexipril
- molindone
- momelotinib
- monomethyl fumarate
- morphine
- morphine liposomal
- moxifloxacin
N
- nabilone
- nabumetone
- nalbuphine
- naltrexone
- nandrolone
- naproxen
- natalizumab
- nefazodone
- nelfinavir
- nevirapine
- niacin
- niacinamide
- nicotinamide
- nilotinib
- nilutamide
- nintedanib
- nirogacestat
- nitrofurantoin
- nortriptyline
O
- olanzapine
- oliceridine
- olopatadine nasal
- olutasidenib
- omaveloxolone
- omeprazole
- onasemnogene abeparvovec
- opicapone
- opium
- oritavancin
- orlistat
- orphenadrine
- osilodrostat
- oxaliplatin
- oxandrolone
- oxaprozin
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxycodone
- oxymetholone
- oxymorphone
P
- paliperidone
- panobinostat
- paraldehyde
- paramethadione
- paroxetine
- pasireotide
- pazopanib
- pegaspargase
- peginterferon alfa-2a
- peginterferon alfa-2b
- peginterferon beta-1a
- pemoline
- pennyroyal
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phenazopyridine
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phenylbutazone
- phenytoin
- pimozide
- pioglitazone
- pirfenidone
- piroxicam
- pirtobrutinib
- pitavastatin
- polatuzumab vedotin
- ponatinib
- ponesimod
- posaconazole
- pralatrexate
- pralsetinib
- pramipexole
- pravastatin
- pregabalin
- primidone
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propiomazine
- propoxyphene
- propylthiouracil
- protriptyline
- pyrazinamide
- pyrilamine
Q
R
- ramelteon
- ramipril
- rasagiline
- red yeast rice
- regorafenib
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repotrectinib
- resmetirom
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilpivirine
- riluzole
- rimegepant
- ripretinib
- risperidone
- ritlecitinib
- ritonavir
- rofecoxib
- ropeginterferon alfa-2b
- ropinirole
- rosiglitazone
- rosuvastatin
- rotigotine
- rufinamide
S
- safinamide
- saquinavir
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- selegiline
- selpercatinib
- sertraline
- sibutramine
- simvastatin
- siponimod
- sirolimus
- sodium oxybate
- sorafenib
- sotorasib
- sparsentan
- st. john's wort
- stanozolol
- stavudine
- stiripentol
- sufentanil
- sulfadiazine
- sulfadoxine
- sulfamethizole
- sulfamethoxazole
- sulfasalazine
- sulfisoxazole
- sulindac
- sunitinib
- suvorexant
T
- tacrine
- tacrolimus
- tagraxofusp
- talquetamab
- tamoxifen
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- teclistamab
- tecovirimat
- telaprevir
- telithromycin
- temazepam
- temozolomide
- temsirolimus
- tenofovir alafenamide
- tenofovir disoproxil
- tepotinib
- terbinafine
- teriflunomide
- testosterone
- testosterone topical
- tetrabenazine
- thalidomide
- theophylline
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticlopidine
- tipranavir
- tizanidine
- tocilizumab
- tolcapone
- tolmetin
- tolvaptan
- topiramate
- tovorafenib
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- treosulfan
- tretinoin
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimetrexate
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- trovafloxacin
- tucatinib
U
V
- vadadustat
- valbenazine
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- vemurafenib
- venetoclax
- venlafaxine
- verapamil
- vibegron
- vigabatrin
- vimseltinib
- vincristine
- vincristine liposome
- vorasidenib
- voriconazole
- voxelotor
W
Z
- zafirlukast
- zalcitabine
- zaleplon
- ziconotide
- zidovudine
- zileuton
- ziprasidone
- zolpidem
- zonisamide
- zuranolone
Epidiolex alcohol/food interactions
There are 2 alcohol/food interactions with Epidiolex (cannabidiol).
Epidiolex disease interactions
There are 2 disease interactions with Epidiolex (cannabidiol) which include:
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More about Epidiolex (cannabidiol)
- Epidiolex consumer information
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- Compare alternatives
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- Reviews (4)
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- Latest FDA alerts (2)
- Side effects
- Dosage information
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- FDA approval history
- Drug class: miscellaneous anticonvulsants
- Breastfeeding
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
