Duocaine Interactions
There are 568 drugs known to interact with Duocaine (bupivacaine / lidocaine), along with 9 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 37 are major, 424 are moderate, and 107 are minor.
- View Duocaine alcohol/food interactions (2)
- View Duocaine disease interactions (9)
Medications known to interact with Duocaine
Note: Showing generic names only.
A
- abametapir topical
- acebutolol
- acetaminophen
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- albendazole
- alefacept
- alfentanil
- allopurinol
- alprazolam
- amifampridine
- amikacin
- amikacin liposome
- aminoglutethimide
- aminosalicylic acid
- amiodarone
- amisulpride
- amitriptyline
- amobarbital
- amoxapine
- amprenavir
- amyl nitrite
- anagrelide
- anakinra
- apalutamide
- apomorphine
- aprepitant
- arbutamine
- aripiprazole
- armodafinil
- asenapine
- atazanavir
- atenolol
- atovaquone
- atracurium
- azatadine
- azelastine nasal
B
- baclofen
- belzutifan
- benoxinate ophthalmic
- benzocaine topical
- benztropine
- berotralstat
- betaxolol
- betaxolol ophthalmic
- bexarotene
- bimekizumab
- biperiden
- bisoprolol
- boceprevir
- bosentan
- bretylium
- brexpiprazole
- brigatinib
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- butabarbital
- butalbital
- butorphanol
C
- canakinumab
- cannabidiol
- cannabis
- capmatinib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carteolol ophthalmic
- carvedilol
- celecoxib
- cenobamate
- ceritinib
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorotrianisene
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cimetidine
- ciprofloxacin
- cisatracurium
- citalopram
- clarithromycin
- clemastine
- clobazam
- clofazimine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- conivaptan
- conjugated estrogens
- conjugated estrogens topical
- crizotinib
- cyclizine
- cyclobenzaprine
- cyclophosphamide
- cyproheptadine
D
- dabrafenib
- dantrolene
- dapsone
- dapsone topical
- daridorexant
- darifenacin
- darunavir
- dasatinib
- deferasirox
- dehydroepiandrosterone
- delavirdine
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dextromethorphan
- dezocine
- diazepam
- dibucaine topical
- dienestrol topical
- diethylstilbestrol
- difelikefalin
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- dofetilide
- dopamine
- doxacurium
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- duvelisib
E
- echinacea
- efavirenz
- elafibranor
- elagolix
- elranatamab
- emapalumab
- enasidenib
- encorafenib
- enoxacin
- ensartinib
- entacapone
- enzalutamide
- epcoritamab
- erythromycin
- escitalopram
- eslicarbazepine
- esmolol
- estazolam
- esterified estrogens
- estradiol
- estradiol topical
- estrone
- estropipate
- estropipate topical
- eszopiclone
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etrasimod
- etravirine
- evening primrose
- ezogabine
F
- fedratinib
- felbamate
- fenfluramine
- fentanyl
- fexinidazole
- flavoxate
- flecainide
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- flutamide
- fluvoxamine
- fosamprenavir
- fosaprepitant
- fosphenytoin
- fostamatinib
G
- gabapentin
- gabapentin enacarbil
- ganaxolone
- gentamicin
- ginkgo
- givosiran
- glofitamab
- glycerol phenylbutyrate
- golimumab
- griseofulvin
- guanfacine
- guselkumab
H
- halazepam
- haloperidol
- heroin
- hyaluronidase
- hydrocodone
- hydromorphone
- hydroxyprogesterone
- hydroxyurea
- hydroxyzine
I
- ibutilide
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indinavir
- indium oxyquinoline in-111
- infliximab
- iohexol
- iomeprol
- iopamidol
- iptacopan
- isavuconazonium
- isocarboxazid
- isosorbide
- isosorbide dinitrate
- isosorbide mononitrate
- itraconazole
- ivacaftor
- ivosidenib
K
L
- labetalol
- lacosamide
- lamotrigine
- landiolol
- lanreotide
- lapatinib
- larotrectinib
- lazertinib
- lefamulin
- lemborexant
- lenacapavir
- leniolisib
- lesinurad
- letermovir
- levetiracetam
- levobetaxolol ophthalmic
- levobunolol ophthalmic
- levobupivacaine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levorphanol
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- lindane topical
- lithium
- lofexidine
- lonafarnib
- lonapegsomatropin
- lorazepam
- lorlatinib
- loxapine
- lumateperone
- lurasidone
M
- mafenide topical
- maprotiline
- mavacamten
- mavorixafor
- meclizine
- mefloquine
- melatonin
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaxalone
- methadone
- methdilazine
- methocarbamol
- methohexital
- methotrimeprazine
- methsuximide
- methyldopa
- metipranolol ophthalmic
- metoclopramide
- metocurine
- metoprolol
- metreleptin
- metrizamide
- metyrosine
- mexiletine
- mibefradil
- midazolam
- mifepristone
- mirtazapine
- mitapivat
- mitotane
- mivacurium
- mobocertinib
- modafinil
- molindone
- momelotinib
- moricizine
- morphine
- morphine liposomal
- mosunetuzumab
N
- nabilone
- nadolol
- nafcillin
- nalbuphine
- nebivolol
- nefazodone
- nelfinavir
- nemolizumab
- neomycin
- netilmicin
- nevirapine
- nicotine
- nilotinib
- niraparib
- nirogacestat
- nitazoxanide
- nitric oxide
- nitrofurantoin
- nitroglycerin
- nitroprusside
- nitrous oxide
- nortriptyline
O
- obeticholic acid
- octreotide
- olanzapine
- olaparib
- oliceridine
- olutasidenib
- omaveloxolone
- omeprazole
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- oxazepam
- oxcarbazepine
- oxycodone
- oxymorphone
P
- pacritinib
- paliperidone
- pancuronium
- paraldehyde
- paramethadione
- paromomycin
- paroxetine
- pasireotide
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phenazopyridine
- phenelzine
- phenindamine
- phenobarbital
- phensuximide
- phenylbutazone
- phenytoin
- pindolol
- pipecuronium
- pirtobrutinib
- plazomicin
- polyethylene glycol 3350 with electrolytes
- posaconazole
- pralsetinib
- pramipexole
- pramoxine topical
- pregabalin
- prilocaine
- primaquine
- primidone
- procainamide
- procaine
- procaine penicillin
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- proparacaine ophthalmic
- propiomazine
- propranolol
- protriptyline
- pyrilamine
Q
R
- raloxifene
- ramelteon
- rapacuronium
- rasagiline
- rasburicase
- remifentanil
- remimazolam
- repotrectinib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- risperidone
- ritlecitinib
- ritonavir
- rocuronium
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- saquinavir
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- sertraline
- sibutramine
- siltuximab
- silver nitrate topical
- silver sulfadiazine topical
- sirolimus
- sodium nitrite
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotalol
- sotorasib
- st. john's wort
- stiripentol
- streptomycin
- succinylcholine
- sufentanil
- sulfadiazine
- sulfamethizole
- sulfamethoxazole
- sulfasalazine
- sulfinpyrazone
- sulfisoxazole
- suvorexant
- suzetrigine
T
- tacrolimus
- tafenoquine
- talquetamab
- tapentadol
- tarlatamab
- tasimelteon
- tazemetostat
- tebentafusp
- teclistamab
- tecovirimat
- telaprevir
- telithromycin
- telotristat
- temazepam
- temsirolimus
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- thallous chloride, tl-201
- thiethylperazine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- tilmanocept
- timolol
- timolol ophthalmic
- tobramycin
- tocainide
- tocilizumab
- tofacitinib
- tolcapone
- tolterodine
- topiramate
- tovorafenib
- tramadol
- tranylcypromine
- trazodone
- triazolam
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimethoprim
- trimipramine
- tripelennamine
- triprolidine
- trofinetide
- troglitazone
- troleandomycin
- tubocurarine
- tucatinib
U
V
- vadadustat
- valbenazine
- valerian
- valproic acid
- varenicline
- vecuronium
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- viloxazine
- vorasidenib
- voriconazole
- voxelotor
Z
Duocaine alcohol/food interactions
There are 2 alcohol/food interactions with Duocaine (bupivacaine / lidocaine).
Duocaine disease interactions
There are 9 disease interactions with Duocaine (bupivacaine / lidocaine) which include:
- cardiovascular dysfunction
- hepatic dysfunction
- renal dysfunction
- seizures
- sinus/AV node dysfunction
- electrolyte imbalance
- cardiovascular disease
- liver disease
- renal impairment
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.