Acetaminophen/tramadol Drug Interactions
Currently displaying a list of 776 drugs known to interact with acetaminophen / tramadol.
- 325 major drug interactions
- 438 moderate drug interactions
- 13 minor drug interactions
Medications known to interact with acetaminophen/tramadol
Note: Showing generic names only.
5
A
- abametapir topical
- abarelix
- abiraterone
- acetylcarbromal
- acrivastine
- adagrasib
- adalimumab
- adenosine
- albuterol
- aldesleukin
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alprazolam
- alvimopan
- amantadine
- amifampridine
- aminoglutethimide
- aminophylline
- amiodarone
- amisulpride
- amitriptyline
- amlodipine
- amobarbital
- amoxapine
- amphetamine
- amprenavir
- anagrelide
- anakinra
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprepitant
- arformoterol
- aripiprazole
- armodafinil
- arsenic trioxide
- asciminib
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- astemizole
- atazanavir
- atezolizumab
- atomoxetine
- atropine
- avacopan
- avelumab
- azatadine
- azelastine nasal
- azithromycin
B
- baclofen
- baricitinib
- bedaquiline
- belladonna
- belzutifan
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzphetamine
- benztropine
- bepridil
- berotralstat
- bethanechol
- bexarotene
- bicalutamide
- bimekizumab
- biperiden
- bisacodyl
- bitolterol
- black cohosh
- blinatumomab
- boceprevir
- bosentan
- bosutinib
- brentuximab
- brexanolone
- brexpiprazole
- brigatinib
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- cabozantinib
- calaspargase pegol
- canakinumab
- cannabidiol
- cannabis
- capivasertib
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- casanthranol
- cascara sagrada
- castor oil
- cefiderocol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- charcoal
- chlophedianol
- chloral hydrate
- chloramphenicol
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chloroquine
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorzoxazone
- cholestyramine
- cilostazol
- cimetidine
- cinacalcet
- cinoxacin
- ciprofloxacin
- cisapride
- citalopram
- clarithromycin
- clemastine
- clidinium
- clobazam
- clofarabine
- clofazimine
- clomipramine
- clonazepam
- clonidine
- clopidogrel
- clorazepate
- clotrimazole
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- conivaptan
- cosibelimab
- crizotinib
- cyclizine
- cyclobenzaprine
- cycloserine
- cyclosporine
- cyproheptadine
D
- dabrafenib
- daclizumab
- dacomitinib
- dalfampridine
- danazol
- dantrolene
- daridorexant
- darifenacin
- darolutamide
- darunavir
- dasatinib
- daunorubicin
- daunorubicin liposomal
- deferasirox
- degarelix
- delafloxacin
- delavirdine
- desflurane
- desipramine
- desmopressin
- desvenlafaxine
- deutetrabenazine
- dexamethasone
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- dibucaine topical
- dicumarol
- dicyclomine
- diethylpropion
- difelikefalin
- diflunisal
- digoxin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- dofetilide
- dolasetron
- donepezil
- dostarlimab
- doxapram
- doxepin
- doxepin topical
- doxorubicin
- doxorubicin liposomal
- doxylamine
- dronabinol
- dronedarone
- droperidol
- duloxetine
- durvalumab
- duvelisib
E
- echinacea
- efavirenz
- elafibranor
- elagolix
- eletriptan
- eliglustat
- eluxadoline
- emapalumab
- encorafenib
- enflurane
- enoxacin
- entacapone
- entrectinib
- enzalutamide
- ephedrine
- epirubicin
- ergotamine
- eribulin
- ertapenem
- erythromycin
- escitalopram
- esketamine
- eslicarbazepine
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- etrasimod
- etravirine
- evening primrose
- ezogabine
F
- famotidine
- fedratinib
- felbamate
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- fingolimod
- flavoxate
- flecainide
- flibanserin
- fluconazole
- fluoxetine
- fluphenazine
- flurazepam
- flutamide
- fluvoxamine
- formoterol
- fosamprenavir
- fosaprepitant
- foscarnet
- fosphenytoin
- fospropofol
- fostemsavir
- frovatriptan
- furazolidone
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gatifloxacin
- gemifloxacin
- gepirone
- gilteritinib
- ginger
- ginkgo
- givinostat
- givosiran
- glasdegib
- glofitamab
- glycerin
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- goldenseal
- golimumab
- goserelin
- granisetron
- grepafloxacin
- griseofulvin
- guselkumab
H
- halazepam
- halofantrine
- haloperidol
- halothane
- heroin
- histrelin
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- ibutilide
- idarubicin
- idelalisib
- ifosfamide
- iloperidone
- imatinib
- imipramine
- indacaterol
- indinavir
- indocyanine green
- infliximab
- inotuzumab ozogamicin
- interferon alfa-2a
- interferon alfa-2b
- interferon alfa-n1
- interferon alfa-n3
- interferon alfacon-1
- interferon beta-1a
- interferon beta-1b
- interferon gamma-1b
- iobenguane I 131
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- iptacopan
- isavuconazonium
- isocarboxazid
- isoetharine
- isoflurane
- isoniazid
- isoproterenol
- itraconazole
- ivabradine
- ivacaftor
- ivosidenib
K
L
- lactitol
- lactulose
- lamotrigine
- lapatinib
- larotrectinib
- lasmiditan
- lazertinib
- lefamulin
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- lenvatinib
- lesinurad
- letermovir
- leuprolide
- levalbuterol
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levofloxacin
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- lindane topical
- linezolid
- liraglutide
- lisdexamfetamine
- lithium
- lofexidine
- lomefloxacin
- lomitapide
- lonafarnib
- lonapegsomatropin
- loperamide
- lorazepam
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- macimorelin
- magnesium citrate
- magnesium hydroxide
- maprotiline
- mavacamten
- mavorixafor
- mazindol
- meclizine
- mefloquine
- melatonin
- mepenzolate
- meperidine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- meropenem
- mesoridazine
- metaproterenol
- metaxalone
- methadone
- methamphetamine
- methdilazine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- methylphenidate
- metoclopramide
- metreleptin
- metrizamide
- metronidazole
- metyrosine
- mexiletine
- mibefradil
- miconazole
- midazolam
- midostaurin
- mifepristone
- milnacipran
- mineral oil
- mipomersen
- mirabegron
- mirtazapine
- mitapivat
- mitotane
- mobocertinib
- modafinil
- molindone
- morphine
- morphine liposomal
- moxifloxacin
- muromonab-cd3
N
- nabilone
- nafcillin
- nalbuphine
- nalidixic acid
- naloxone
- naltrexone
- naratriptan
- nefazodone
- nelarabine
- nelfinavir
- nemolizumab
- neostigmine
- nevirapine
- nicotine
- nifedipine
- nilotinib
- nilutamide
- niraparib
- nirogacestat
- nitrous oxide
- nivolumab
- norfloxacin
- nortriptyline
O
- ofloxacin
- olanzapine
- oliceridine
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- osimertinib
- ospemifene
- oxaliplatin
- oxamniquine
- oxazepam
- oxcarbazepine
- oxtriphylline
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
P
- pacritinib
- palbociclib
- paliperidone
- palonosetron
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- pasireotide
- pazopanib
- pegaspargase
- peginterferon alfa-2a
- peginterferon alfa-2b
- peginterferon beta-1a
- pegvisomant
- pembrolizumab
- pemoline
- pentamidine
- pentazocine
- pentobarbital
- perampanel
- perflutren
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phenolphthalein
- phensuximide
- phentermine
- phenylbutazone
- phenylpropanolamine
- phenytoin
- physostigmine
- pimavanserin
- pimozide
- piperazine
- pirbuterol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350
- polyethylene glycol 3350 with electrolytes
- ponesimod
- posaconazole
- pralsetinib
- pramipexole
- pramoxine topical
- prasugrel
- pregabalin
- primaquine
- primidone
- probenecid
- probucol
- procainamide
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- pseudoephedrine
- pyrilamine
Q
R
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- relugolix
- remdesivir
- remifentanil
- remimazolam
- repotrectinib
- retifanlimab
- revumenib
- ribociclib
- rifabutin
- rifampin
- rifapentine
- rilonacept
- rilpivirine
- rimantadine
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rivastigmine
- rizatriptan
- rolapitant
- romidepsin
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- salmeterol
- saquinavir
- sarilumab
- satralizumab
- scopolamine
- secobarbital
- secukinumab
- selegiline
- selpercatinib
- senna
- sertraline
- sevoflurane
- sibutramine
- siltuximab
- siponimod
- sodium oxybate
- sodium polystyrene sulfonate
- sodium salicylate
- sofpironium topical
- solifenacin
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sorafenib
- sotalol
- sotorasib
- sparfloxacin
- st. john's wort
- stiripentol
- sufentanil
- sulfamethoxazole
- sulfinpyrazone
- sumatriptan
- sunitinib
- suvorexant
- suzetrigine
T
- tacrine
- tacrolimus
- tafamidis
- tamoxifen
- tapentadol
- tasimelteon
- tazemetostat
- tebentafusp
- tecovirimat
- tedizolid
- telaprevir
- telavancin
- telithromycin
- telotristat
- temazepam
- terbinafine
- terbutaline
- terfenadine
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- theophylline
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- tiagabine
- ticagrelor
- tirzepatide
- tislelizumab
- tizanidine
- tocilizumab
- tofacitinib
- tolcapone
- tolterodine
- topiramate
- toremifene
- toripalimab
- tovorafenib
- trabectedin
- tranylcypromine
- trazodone
- tremelimumab
- treosulfan
- triazolam
- triclabendazole
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- triptorelin
- trofinetide
- troglitazone
- troleandomycin
- trospium
- trovafloxacin
- tryptophan
- tucatinib
U
V
- vadadustat
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- vandetanib
- vardenafil
- varenicline
- vasopressin
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
- vilazodone
- viloxazine
- voclosporin
- vonoprazan
- vorasidenib
- voriconazole
- vortioxetine
- voxelotor
W
Z
Acetaminophen/tramadol alcohol/food interactions
There is 1 alcohol/food interaction with acetaminophen / tramadol.
Acetaminophen/tramadol disease interactions
There are 15 disease interactions with acetaminophen / tramadol which include:
- alcoholism
- liver disease
- gastrointestinal obstruction
- acute alcohol intoxication
- drug dependence
- respiratory depression
- PKU
- gastrointestinal conditions
- hypoglycemia
- hypotension
- intracranial pressure
- liver disease
- renal dysfunction
- seizure disorders
- suicidal
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More about acetaminophen / tramadol
- acetaminophen/tramadol consumer information
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- Compare alternatives
- Pricing & coupons
- Reviews (62)
- Drug images
- Latest FDA alerts (5)
- Side effects
- Dosage information
- During pregnancy
- Drug class: narcotic analgesic combinations
- En español
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
