Acetaminophen/diphenhydramine/pseudoephedrine Interactions
There are 697 drugs known to interact with acetaminophen/diphenhydramine/pseudoephedrine, along with 17 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 44 are major, 634 are moderate, and 19 are minor.
- View all 697 medications that may interact with acetaminophen/diphenhydramine/pseudoephedrine
- View acetaminophen/diphenhydramine/pseudoephedrine alcohol/food interactions (3)
- View acetaminophen/diphenhydramine/pseudoephedrine disease interactions (17)
Most frequently checked interactions
View interaction reports for acetaminophen / diphenhydramine / pseudoephedrine and the medicines listed below.
- Advil (ibuprofen)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Align (bifidobacterium infantis)
- Anusol (pramoxine/zinc oxide topical)
- Anusol-HC (hydrocortisone topical)
- Atarax (hydroxyzine)
- Benadryl (diphenhydramine)
- Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)
- Benylin DM (dextromethorphan)
- Biotene Moisturizing Mouth Spray (saliva substitutes topical)
- Bonine (meclizine)
- Cymbalta (duloxetine)
- Dexilant (dexlansoprazole)
- Dymista (azelastine / fluticasone nasal)
- Evening Primrose Oil (evening primrose)
- Ex-Lax Maximum Relief Formula (senna)
- Excedrin Migraine (acetaminophen / aspirin / caffeine)
- Gaviscon Extra Strength (aluminum hydroxide / magnesium carbonate)
- Mirena (levonorgestrel)
- Multivitamins and Minerals (multivitamin with minerals)
- Myoflex (trolamine salicylate topical)
- Nicorette (nicotine)
- Omega 3-6-9 Complex (omega-3 polyunsaturated fatty acids)
- Omega-3 (omega-3 polyunsaturated fatty acids)
- One-A-Day WeightSmart (multivitamin with minerals)
- PC Pen VK (penicillin v potassium)
- Polysporin Ophthalmic (bacitracin / polymyxin b ophthalmic)
- Prometrium (progesterone)
- Tylenol (acetaminophen)
- Vitamin C (ascorbic acid)
Acetaminophen/diphenhydramine/pseudoephedrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / diphenhydramine / pseudoephedrine.
Acetaminophen/diphenhydramine/pseudoephedrine disease interactions
There are 17 disease interactions with acetaminophen / diphenhydramine / pseudoephedrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
Report options
More about acetaminophen / diphenhydramine / pseudoephedrine
- Compare alternatives
- Drug images
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Diphenhydramine
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Benadryl
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Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Flonase
Flonase (fluticasone nasal) is used to treat nasal congestion, sneezing, and runny nose caused by ...
Promethazine DM
Promethazine DM is used for allergic rhinitis, cold symptoms, cough
Flonase Allergy Relief
Flonase Allergy Relief is used for allergic rhinitis, allergies, rhinitis
Levsin
Levsin is used to treat stomach problems such as cramps and irritable bowel syndrome and conditions ...
Xhance
Xhance (fluticasone propionate) is a corticosteroid nasal spray with a unique exhalation delivery ...
Benadryl Allergy
Benadryl Allergy is used for allergic reactions, allergic rhinitis, allergies, cold symptoms ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
