Acetaminophen/diphenhydramine/pseudoephedrine Interactions
There are 698 drugs known to interact with acetaminophen/diphenhydramine/pseudoephedrine, along with 17 disease interactions, and 3 alcohol/food interactions. Of the total drug interactions, 44 are major, 635 are moderate, and 19 are minor.
- View all 698 medications that may interact with acetaminophen/diphenhydramine/pseudoephedrine
- View acetaminophen/diphenhydramine/pseudoephedrine alcohol/food interactions (3)
- View acetaminophen/diphenhydramine/pseudoephedrine disease interactions (17)
Most frequently checked interactions
View interaction reports for acetaminophen / diphenhydramine / pseudoephedrine and the medicines listed below.
- Advil (ibuprofen)
- Advil (ibuprofen)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Advil Cold and Sinus (ibuprofen / pseudoephedrine)
- Anusol (pramoxine/zinc oxide topical)
- Anusol (pramoxine/zinc oxide topical)
- Anusol-HC (hydrocortisone topical)
- Anusol-HC (hydrocortisone topical)
- Atarax (hydroxyzine)
- Atarax (hydroxyzine)
- Benadryl (diphenhydramine)
- Benadryl (diphenhydramine)
- Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)
- Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)
- Benylin DM (dextromethorphan)
- Benylin DM (dextromethorphan)
- Biotene Moisturizing Mouth Spray (saliva substitutes topical)
- Biotene Moisturizing Mouth Spray (saliva substitutes topical)
- Bonine (meclizine)
- Bonine (meclizine)
- Cymbalta (duloxetine)
- Cymbalta (duloxetine)
- Dexilant (dexlansoprazole)
- Dexilant (dexlansoprazole)
- Dymista (azelastine / fluticasone nasal)
- Dymista (azelastine / fluticasone nasal)
- Tylenol (acetaminophen)
- Tylenol (acetaminophen)
- Vitamin C (ascorbic acid)
- Vitamin C (ascorbic acid)
Acetaminophen/diphenhydramine/pseudoephedrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / diphenhydramine / pseudoephedrine.
Acetaminophen/diphenhydramine/pseudoephedrine disease interactions
There are 17 disease interactions with acetaminophen / diphenhydramine / pseudoephedrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
Report options
More about acetaminophen / diphenhydramine / pseudoephedrine
- Compare alternatives
- Drug images
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
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Promethazine DM
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Botox
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Banophen
Banophen is used for allergic reactions, allergic rhinitis, cold symptoms, cough, extrapyramidal ...
Benadryl Allergy
Benadryl Allergy is used for allergic reactions, allergic rhinitis, allergies, cold symptoms ...
Dologesic
Dologesic is used for cold symptoms, headache, influenza, pain
Echinacea
Echinacea is used for cold symptoms, condylomata acuminata, herbal supplementation
Chlorpheniramine
Chlorpheniramine is used for allergic reactions, allergic rhinitis, allergies, cold symptoms, food ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
