Acetaminophen/diphenhydramine/pseudoephedrine Drug Interactions
Currently displaying a list of 697 drugs known to interact with acetaminophen / diphenhydramine / pseudoephedrine.
- 44 major drug interactions
- 634 moderate drug interactions
- 19 minor drug interactions
Medications known to interact with acetaminophen/diphenhydramine/pseudoephedrine
Note: Showing generic names only.
A
- abiraterone
- abobotulinumtoxinA
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- adagrasib
- albiglutide
- albuterol
- aldesleukin
- alfentanil
- alfuzosin
- allopurinol
- alogliptin
- alprazolam
- amantadine
- amifampridine
- amiloride
- aminophylline
- amiodarone
- amitriptyline
- amlodipine
- ammonium chloride
- amobarbital
- amoxapine
- amphetamine
- amyl nitrite
- anagrelide
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- aprocitentan
- arformoterol
- aripiprazole
- armodafinil
- ascorbic acid
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atezolizumab
- atomoxetine
- atropine
- avelumab
- azatadine
- azelastine nasal
- azilsartan medoxomil
B
- baclofen
- bedaquiline
- belladonna
- benazepril
- bendroflumethiazide
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- berotralstat
- betaxolol
- bexagliflozin
- biperiden
- bisoprolol
- bitolterol
- black cohosh
- brentuximab
- bretylium
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- bromocriptine
- brompheniramine
- bumetanide
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
C
- caffeine
- calaspargase pegol
- canagliflozin
- candesartan
- cannabidiol
- cannabis
- capivasertib
- captopril
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carteolol
- carvedilol
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- cevimeline
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chlorothiazide
- chlorphenesin
- chlorpheniramine
- chlorpromazine
- chlorpropamide
- chlorthalidone
- chlorzoxazone
- cholestyramine
- cimetidine
- citalopram
- clemastine
- clevidipine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
D
- daclizumab
- dacomitinib
- dantrolene
- dapagliflozin
- daridorexant
- darifenacin
- daxibotulinumtoxinA
- deferasirox
- demecarium bromide ophthalmic
- deserpidine
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dextromethorphan
- dezocine
- diazepam
- diazoxide
- dibucaine topical
- dicumarol
- dicyclomine
- diethylpropion
- difelikefalin
- diflunisal
- digitoxin
- digoxin
- dihydroergotamine
- diltiazem
- dimenhydrinate
- disopyramide
- divalproex sodium
- dobutamine
- dofetilide
- donepezil
- dopamine
- dostarlimab
- doxapram
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- droxidopa
- dulaglutide
- duloxetine
- durvalumab
E
- echinacea
- echothiophate iodide ophthalmic
- efavirenz
- eliglustat
- eluxadoline
- empagliflozin
- enalapril
- enalaprilat
- encorafenib
- enflurane
- entacapone
- ephedrine
- epinephrine
- epirubicin
- eplerenone
- epoprostenol
- eprosartan
- ergonovine
- ergotamine
- ertugliflozin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethacrynic acid
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- evening primrose
- exenatide
- ezogabine
F
- fedratinib
- felbamate
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosinopril
- fosphenytoin
- fospropofol
- furazolidone
- furosemide
G
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- ginkgo
- givosiran
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- guanabenz
- guanadrel
- guanethidine
- guanfacine
H
- halazepam
- haloperidol
- halothane
- heroin
- histamine phosphate
- house dust mite allergen extract
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocodone
- hydroflumethiazide
- hydromorphone
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
I
- ibutilide
- idelalisib
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- incobotulinumtoxinA
- indacaterol
- indapamide
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iobenguane I 123
- iobenguane I 131
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- ipratropium
- ipratropium nasal
- irbesartan
- isocarboxazid
- isoetharine
- isoflurane
- isoflurophate ophthalmic
- isoniazid
- isoproterenol
- isosorbide dinitrate
- isosorbide mononitrate
- isradipine
K
L
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- leflunomide
- lemborexant
- leniolisib
- letibotulinumtoxinA
- levalbuterol
- levamlodipine
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- levothyroxine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- lindane topical
- linezolid
- liothyronine
- liraglutide
- lisdexamfetamine
- lisinopril
- lithium
- lixisenatide
- lofexidine
- lomitapide
- loperamide
- lorazepam
- lorcaserin
- lorlatinib
- losartan
- loxapine
- lumateperone
- lurasidone
M
- ma huang
- maprotiline
- mavorixafor
- mazindol
- mecamylamine
- meclizine
- melatonin
- mepenzolate
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- metformin
- methadone
- methamphetamine
- methdilazine
- methionine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methoxamine
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methysergide maleate
- metoclopramide
- metolazone
- metoprolol
- metrizamide
- metyrosine
- mibefradil
- midazolam
- midodrine
- miglitol
- milnacipran
- minoxidil
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- mixed grass pollens allergen extract
- modafinil
- moexipril
- molindone
- morphine
- morphine liposomal
N
- nabilone
- nadolol
- nalbuphine
- naltrexone
- nateglinide
- nebivolol
- nefazodone
- nicardipine
- nicotine
- nifedipine
- nilotinib
- nimodipine
- niraparib
- nisoldipine
- nitroglycerin
- nitroprusside
- nivolumab
- norepinephrine
- nortriptyline
O
- olanzapine
- oliceridine
- olmesartan
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- onabotulinumtoxinA
- opicapone
- opium
- oritavancin
- orphenadrine
- ospemifene
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
P
- paliperidone
- panobinostat
- papaverine
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- penbutolol
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perindopril
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylephrine
- phenylpropanolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pioglitazone
- pirbuterol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- polythiazide
- porfimer
- potassium acid phosphate
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pralsetinib
- pramipexole
- pramlintide
- pramoxine topical
- prazosin
- pregabalin
- primidone
- probenecid
- procainamide
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propantheline
- proparacaine ophthalmic
- propiomazine
- propofol
- propoxyphene
- propranolol
- protriptyline
- prucalopride
- pyrilamine
Q
R
- racepinephrine
- ragweed pollen allergen extract
- ramelteon
- ramipril
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- reserpine
- retifanlimab
- revefenacin
- rifampin
- rimabotulinumtoxinB
- risperidone
- ritlecitinib
- ritodrine
- rivastigmine
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
S
- safinamide
- salmeterol
- saxagliptin
- scopolamine
- secobarbital
- selegiline
- selexipag
- semaglutide
- sertraline
- sevoflurane
- sibutramine
- silodosin
- sitagliptin
- sodium acetate
- sodium bicarbonate
- sodium citrate
- sodium iodide i-123
- sodium iodide-i-131
- sodium lactate
- sodium oxybate
- sodium salicylate
- solifenacin
- solriamfetol
- sotagliflozin
- sotalol
- sparsentan
- spironolactone
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- suvorexant
T
- tacrine
- tafamidis
- tamoxifen
- tamsulosin
- tapentadol
- tasimelteon
- telmisartan
- temazepam
- terazosin
- terbutaline
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- theophylline
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- timolol
- timolol ophthalmic
- timothy grass pollen allergen extract
- tiotropium
- tirzepatide
- tislelizumab
- tizanidine
- tolazamide
- tolazoline
- tolbutamide
- tolcapone
- tolterodine
- topiramate
- toripalimab
- torsemide
- trabectedin
- tramadol
- trandolapril
- tranylcypromine
- trazodone
- tremelimumab
- treprostinil
- triamterene
- triazolam
- trichophyton skin test
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethaphan camsylate
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- tromethamine
- trospium
U
V
- valbenazine
- valerian
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- varenicline
- vemurafenib
- venlafaxine
- verapamil
- vigabatrin
W
Z
Acetaminophen/diphenhydramine/pseudoephedrine alcohol/food interactions
There are 3 alcohol/food interactions with acetaminophen / diphenhydramine / pseudoephedrine.
Acetaminophen/diphenhydramine/pseudoephedrine disease interactions
There are 17 disease interactions with acetaminophen / diphenhydramine / pseudoephedrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
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More about acetaminophen / diphenhydramine / pseudoephedrine
- Check interactions
- Compare alternatives
- Drug images
- Side effects
- Dosage information
- Drug class: upper respiratory combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
