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Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) Drug Interactions

A total of 1062 drugs are known to interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

  • 241 major drug interactions
  • 785 moderate drug interactions
  • 36 minor drug interactions

Show all medications in the database that may interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

Check for interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

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Common medications checked in combination with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

  • Advil (ibuprofen)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Moxilin, Amoxicot, Apo-Amoxi, Moxatag, DisperMox, Wymox, Biomox)
  • Azithromycin Dose Pack (azithromycin)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Budeprion, Aplenzin, Forfivo XL, Budeprion SR, Budeprion XL)
  • Crestor (rosuvastatin)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Unisom SleepGels, Dicopanol, Sleep, Diphenhist, Sominex, Diphen, Diphenadryl, Benadryl Children's Allergy, Allermax, Diphenydramine Quick Melt, Nytol, Diphedryl, Hydramine, Diphendryl, Pharbedryl, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen Cough, DPH, Allergia-C, Q-Dryl, Sleep Tabs, Quenalin, Sleep-ettes D, Q-Dryl A/F, Dytan, Vanamine PD, Sleepwell 2-nite, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, 40 Winks, Diphen AF, Aler-Dryl, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Aller-G-Time, Sleep Tab II, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Diphenyl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Uni-Tann, Diphenmax, Nightime Sleepaid, Ben-Tann, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, PediaCare Children's Allergy, Truxadryl, Simply Sleep, Complete Allergy Relief, Dytuss, Dormin, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Proprinal, Motrin IB, Children's Motrin, IBU-200, Advil Migraine, Ibu-8, Motrin Childrens, Nuprin, Motrin Migraine Pain, Ibuprofen PMR, NeoProfen, Caldolor, Advil Children's, Addaprin, Motrin Infant Drops, Advil Infant's Concentrated Drops, Rufen, Genpril, A-G Profen, Ibu-Tab, Haltran, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, Childrens Ibuprofen Berry, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • Lexapro (escitalopram)
  • metoprolol (Metoprolol Tartrate, Metoprolol Succinate ER, Toprol-XL, Lopressor, Kapspargo Sprinkle)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • multivitamin (Metanx, Daflon, Theragran, Folbic, Estroven, Nephro-Vite, Neurobion, Rena-Vite, Vitamins, Cerefolin, Foltx, Folbee, Nephrocaps, Foltanx, Cod Liver Oil, Multi Vitamin+, Cerefolin NAC, Thera, Vitamin B Complex 100, B Complex 100, PoDiaPN, Super B Complex, Lipoflavonoid, Cod Liver Oil Mint, Folic Acid XTRA, Rheumate, Daily Multiple Vitamins, Daily Vite, Nephplex Rx, Infuvite, One-A-Day 50+, Renal Caps, Tab-A-Vite, Essentiale, MVI Adult, Foltrate, Xyzbac, Berocca, Reno Caps, Chewable-Vite, Flintstones Multivitamins, Triphrocaps, Fletanol, Folinic-Plus, Nephro-Vite Rx, Poly-Vi-Sol, Lysiplex, Super B-50, B Complex 50, Nephronex, FaBB, Mebolic, TL Gard, StressTabs, B-Stress, Surbex with C, Surbex, Scotts Emulsion, Hylavite, Prostate 2.4, Rena-Vite Rx, Topfit Vitamin B Complex Forte, Vitamin A and D Concentrate, Folgard RX, Folplex, Vol-Care Rx, Foltanx RF, Virt-Caps, Therems, Childrens Chewable Multivitamins, Balanced B-50, Vitacirc-B, Essential Balance, Fruity Chew, Flintstones with C Multivitamins, Poly Vit Drops, Mynephron, Celebrate B-12, Apetigen, Stress Formula, Vitamin C, E, and Rose Hips, Mega B, L-methylfolate Ca, Me-Cbl NAC, Theragenerix, Cernevit, MTX Support, Cardiotek, Bugs Bunny Multiple Vitamins, Infuvite Pediatric, Vitamin A, D, Folastin, Levomefolate Calcium-Algal Powder, Folbee Plus, Folcaps, Abidec, Topfit Vitamin B Complex, Vitamin B Compound Strong, Jetepar, Centrum 8400, Folbalin, Foltabs 800, One-A-Day Men's Health Formula, Daily-Vite Men's Formula, Biotin Forte, B 100 Complex, B-Plex, Vitaplex, Tri-Vi-Sol, Metafolbic, Metafolbic Plus, Lipogen, Virt-Vite, Virt-Vite Forte, Stress-600, 1000 BC, Neurodep, Cefol, Protegra, Watkins Harvest, Balanced B-100, B-Scorbic, Bee with C, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, One-A-Day Essentials, Vi-Daylin Chewable, Folast, Enfolast, Sunkist Child Chewable with C, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Triphro, Poly-Vit Chew, Vita-Respa, Bugs Bunny with Extra C, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Poly-Vi-Sol Drops, Baby Vitamin Drop, Vita Drop, MVC SDV, Glutofac, Allbee-C, Vitabee with C, Stress B with C, High Potency B+C, Av-VITE FB, Farbee with C, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-50, Folika-T, Vitamin B-100, D-400 international units, Vitamin B-100 T/R, Hexavitamin, Kenwood Therapeutic, Theravite, Thera-Plus, Oncovite, Glycogenics, Beminal-500, High Potency B Complex with B12 and C, Super B-100 TD, Tri-Vit Drops, Flintstones Toddler, One Tab Daily, Stress Formula 600, Tri-Vit, Apatate, T-Vites, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Beminal, Beminal with C Fortis, Full Spectrum B with C, Allbee with C, Prevital, Surbex Filmtab, Tender Age Vitamin ADC, Folgard Rx 2.2, Cernevit-12, SeroSyn, Diatx, Thex Forte, Metafolbic Plus RF, Dosoquin, Protegra Cardio, Virt-Vite Plus, K2 Plus D3, Vitamin Daily Liquid, Renaphro, Apetex, Virt-Gard, Dialyvite Rx, L-Methyl-MC, VP-Vite Rx, Vesselvite, Combgen, Unichem Multivitamin, L-Methyl-B6-B12, Health Aid Multivitamin, AllanTex, One Daily Multi-Essential, Larobec, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Hair, Skin, & Nails Gummies, Folamin, DexFol, Equaline One Daily Essential, Menopause Relief with Lifenol, Av-VITE FB Forte, Folmor, Zycose, Vigomar Forte, Allbee Plus, Vimar, Triveen-CF, Nature's Bounty Hair Skin & Nails, Folbic RF, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Mebolex, Methazel, Dyzbac, Mynephrocaps, Nufola, Omega Q Plus, Acnepril, Super Theravite-M, Primaplex, Becomject-100, Poly-Vita Drops, MVI-12, B-Ject 100, L-Methyl-MC NAC, Therobec, Formula B, Vi-Daylin ADC, Nephrocaps QT, Lipotriad, Folplex 2.2, Cholinoid, Tri-Vita Drops, Thera-Tabs, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Ivites Rx, Zymacap, Vi-Daylin, Dayalets, Sigtab, Allbee-C 800, B-Complex SR, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, T-BMP, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Anaprox-DS, Naprelan, EC-Naprosyn, Flanax Pain Reliever, Aflaxen, All Day Pain Relief, Comfort Pac with Naproxen, Leader Naproxen Sodium, Pamprin All Day Relief, Midol Extended Relief, All Day Relief)
  • prednisone (Deltasone, Rayos, Sterapred, Sterapred DS, Prednicot, Meticorten, Orasone, Liquid Pred, Prednicen-M)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) disease interactions

There are 15 disease interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) which include:

More about Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

Related treatment guides

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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