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Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) Drug Interactions

A total of 1067 drugs are known to interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

  • 241 major drug interactions
  • 789 moderate drug interactions
  • 37 minor drug interactions

Show all medications in the database that may interact with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

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Type in a drug name to check for interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine).

Most frequently checked interactions

View interaction reports for Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) and the medicines listed below.

  • Advil (ibuprofen)
  • Aleve (naproxen)
  • amlodipine (Norvasc)
  • amoxicillin (Amoxil, Trimox, Apo-Amoxi, Amoxicot, DisperMox, Moxatag, Biomox, Wymox, Moxilin)
  • Azithromycin Dose Pack (azithromycin)
  • benzonatate (Tessalon Perles, Tessalon, Zonatuss)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Aplenzin, Budeprion, Forfivo XL, Budeprion XL, Budeprion SR)
  • Crestor (rosuvastatin)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Unisom SleepGels, Benadryl Children's Allergy, Sominex, Dicopanol, Diphen, Sleep Tabs, Simply Sleep, Diphedryl, Diphenadryl, Quenalin, Diphenyl, Hydramine, Diphenydramine Quick Melt, Unisom SleepMelts, Nytol, Dormin, Sleepwell 2-nite, Diphenhist, 40 Winks, Diphen Cough, DPH, Calm-Aid, Sleep Tab II, Altaryl, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Hyrexin, Hydramine Cough Syrup, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Pharbedryl, Histaprin, Z-Sleep, Tranquil Nighttime Sleep Aid, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • ibuprofen (Advil, Motrin, IBU, Advil Liqui-Gels, Children's Motrin, Proprinal, Motrin IB, Childrens Ibuprofen Berry, Advil Children's, Ibuprofen PMR, Ibu-8, Rufen, IBU-200, Motrin Childrens, Advil Migraine, Caldolor, Ibu-Tab, Menadol, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Pediatric, Genpril, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Motrin Junior Strength, Motrin Infant Drops, NeoProfen, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • Lexapro (escitalopram)
  • metoprolol (Metoprolol Succinate ER, Metoprolol Tartrate, Lopressor, Toprol-XL, Kapspargo Sprinkle)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • multivitamin (Daflon, Metanx, Neurobion, Vitamins, Vitamin B Complex 100, Theragran, Rena-Vite, Cerefolin, Cerefolin NAC, Estroven, Nephrocaps, Foltx, Lipoflavonoid, Folbic, Nephro-Vite, Folbee, Renal Caps, Cod Liver Oil, Super B Complex, Foltanx, Essentiale, B Complex 100, Tab-A-Vite, Folic Acid XTRA, Thera, PoDiaPN, Nufola, MVI Adult, Triphrocaps, Topfit Vitamin B Complex, Apetigen, Rheumate, Rena-Vite Rx, Folinic-Plus, FaBB, Xyzbac, Nephro-Vite Rx, Multi Vitamin+, Daily Multiple Vitamins, Daily Vite, Cod Liver Oil Mint, Lysiplex, Flintstones Multivitamins, Surbex, B Complex 50, Dosoquin, Vitamin Daily Liquid, Zyvit, Metafolbic Plus, Lipogen, Virt-Caps, Folika-T, Thera-Plus, High Potency B Complex with B12 and C, Cernevit, MTX Support, Fletanol, Infuvite Pediatric, Apetex, Virt-Gard, Folcaps, L-Methyl-B6-B12, Nephronex, Folgard RX, One-A-Day Men's Health Formula, Poly-Vi-Sol, Therems, StressTabs, Reno Caps, One-A-Day Essentials, Essential Balance, Chewable-Vite, Poly-Vi-Sol Drops, Stress B with C, Vitamin B-50, Hexavitamin, Theravite, Super B-50, Super B-100 TD, Stress Formula, Flintstones Toddler, Hylavite, Theragenerix, Prostate 2.4, Beminal, Bugs Bunny Multiple Vitamins, Infuvite, Folastin, Levomefolate Calcium-Algal Powder, Folbee Plus, Topfit Vitamin B Complex Forte, Vitamin B Compound Strong, Jetepar, Foltrate, Menopause Relief with Lifenol, Daily-Vite Men's Formula, Biotin Forte, Vigomar Forte, Vimar, B 100 Complex, Vol-Care Rx, Folbic RF, Mebolex, Methazel, Berocca, Metafolbic, Folplex 2.2, Thera-Tabs, 1000 BC, Neurodep, Vi-Daylin, B-Complex SR, T-BMP, Watkins Harvest, Balanced B-100, B-Stress, B-Scorbic, Bee with C, Childrens Chewable Multivitamins, Balanced B-50, Nat-Rul B-125, Balanced B-150, Unicap Capsule, Unicap Jr, Vitacirc-B, Unicap, Optilets-500, Super Plenamins, Vitamins for Hair, Vi-Daylin Chewable, Folast, Enfolast, Sunkist Child Chewable with C, Enfolast-N, Sunkist Child Chewable, Poly-Vi-Sol Chewable, Neurpath-B, Fruity Chew, Triphro, Poly-Vit Chew, Vita-Respa, Bugs Bunny with Extra C, Flintstones with C Multivitamins, Geravine, Bounty Bear Vitamins, Garfield Vitamins, Vi-Daylin Drops, Baby Vitamin Drop, Vita Drop, Poly Vit Drops, MVC SDV, Glutofac, Allbee-C, Vitabee with C, High Potency B+C, Av-VITE FB, Farbee with C, Mynephron, Surbex with C, Renatabs, Tri-Vitamin, DEKAs Essential, Vitamin B-100, D-400 international units, Vitamin B-100 T/R, Celebrate B-12, Kenwood Therapeutic, Oncovite, Glycogenics, Beminal-500, Tri-Vit Drops, One Tab Daily, Vitamin C, E, and Rose Hips, Scotts Emulsion, Stress Formula 600, Tri-Vit, Mega B, Apatate, T-Vites, L-methylfolate Ca, Me-Cbl NAC, High B Complex, L-methylfolate Ca, P-5-P, Me-Cbl, Cardiotek, Beminal with C Fortis, Full Spectrum B with C, Allbee with C, Prevital, Surbex Filmtab, Tender Age Vitamin ADC, Folgard Rx 2.2, Cernevit-12, SeroSyn, Diatx, Vitamin A, D, One-A-Day 50+, Thex Forte, Metafolbic Plus RF, Protegra Cardio, Virt-Vite Plus, K2 Plus D3, Renaphro, Dialyvite Rx, L-Methyl-MC, VP-Vite Rx, Vesselvite, Combgen, Abidec, Unichem Multivitamin, Health Aid Multivitamin, AllanTex, Vitamin A and D Concentrate, One Daily Multi-Essential, Centrum 8400, Larobec, Cardiotek Rx, Folbalin Plus, Dialyvite 800, Folbalin, Multi-Delyn, Multi Vits with Beta Carotene, Foleve Plus, Foltabs 800, Folnate, Folnate Plus, B-Complex with B-12, Foleve, Hair, Skin, & Nails Gummies, Folamin, DexFol, Equaline One Daily Essential, Av-VITE FB Forte, Folplex, Folmor, Zycose, Allbee Plus, Triveen-CF, Folika-V, Genicin Vita-Q, Nature's Bounty Hair Skin & Nails, Genicin Vita-S, Tobakient, Foltanx RF, Total B with C, Methaver, GNC Women's Hair, Skin & Nails Formula, Folbee AR, NuFol, Co-Veratrol, Mebolic, Dyzbac, Mynephrocaps, Omega Q Plus, Acnepril, Super Theravite-M, Primaplex, Becomject-100, Poly-Vita Drops, MVI-12, Nephplex Rx, B-Ject 100, L-Methyl-MC NAC, Therobec, B-Plex, Formula B, Vitaplex, Tri-Vi-Sol, TL Gard, Vi-Daylin ADC, Nephrocaps QT, Virt-Vite, Lipotriad, Virt-Vite Forte, Stress-600, Cholinoid, Tri-Vita Drops, Liponol, Bee-Comp with C, Cholidase, Vita-Plus G, Rovin-CF, Cota-B-Plex, Neuroforte-Six, MVI Pediatric, B-Plex Plus, Nephrolan Rx, Ivites Rx, Zymacap, Dayalets, Sigtab, Allbee-C 800, Cefol, Protegra, Wellesse Sugar Free Childrens Multivitamin Gummies, Alz-Nac, Sesame St Vitamins with Extra C, Surbex-T, Male Formula, Superplex-T, Vi-Stress, Animal Shape Vitamins, B-50 Complex, Niva-Fol)
  • naproxen (Aleve, Naprosyn, Naproxen Sodium DS, Anaprox, Naprelan, Anaprox-DS, EC-Naprosyn, Midol Extended Relief, Flanax Pain Reliever, Comfort Pac with Naproxen, Leader Naproxen Sodium, Aflaxen, Pamprin All Day Relief, All Day Pain Relief, All Day Relief)
  • prednisone (Deltasone, Rayos, Sterapred, Prednicot, Meticorten, Sterapred DS, Liquid Pred, Orasone, Prednicen-M)
  • Vitamin D3 (cholecalciferol)
  • Xanax (alprazolam)
  • Zyrtec (cetirizine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) alcohol/food interactions

There is 1 alcohol/food interaction with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) disease interactions

There are 15 disease interactions with Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine) which include:

More about Sudafed PE Severe Cold (acetaminophen / diphenhydramine / phenylephrine)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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