Skip to Content

Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine) Drug Interactions

A total of 1056 drugs are known to interact with Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine).

  • 240 major drug interactions
  • 780 moderate drug interactions
  • 36 minor drug interactions

Show all medications in the database that may interact with Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine).

Check for interactions with Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)

Type in a drug name and select a drug from the list.

Common medications checked in combination with Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)

  • albuterol (ProAir HFA, Ventolin, Ventolin HFA, Proventil, Proventil HFA, Respirol, ProAir RespiClick, AccuNeb, Airet, Volmax, Vospire ER)
  • Aleve (naproxen)
  • aspirin (Aspir 81, Ecotrin, Acetylsalicylic Acid, Aspirin Low Strength, Bayer Aspirin, Aspir-Low, Ascriptin, Arthritis Pain, Fasprin, Ecotrin Adult Low Strength, Low Dose ASA, Bufferin, Aspiritab, Aspirin Lite Coat, Easprin, Bayer Children's Aspirin, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Aspirtab, Halfprin, Aspergum, Durlaza, Acuprin 81, Miniprin, Bufferin Low Dose, Empirin, Buffered Aspirin, Entercote, St. Joseph Aspirin, Ascriptin Enteric, Ecpirin, Bayer Women's Aspirin With Calcium, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspi-Cor, Medi-Seltzer, Sloprin, St. Joseph 81 mg Chewable Aspirin, ZORprin, Bayer Aspirin Extra Strength Plus, Buffex, Ecotrin Maximum Strength, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Bufferin Extra Strength, Therapy Bayer, Stanback Analgesic, Norwich Aspirin, Zero-Order Release, YSP Aspirin, Migralex, Heartline, Bayer Advanced Aspirin, Buffasal)
  • Aspirin Low Strength (aspirin)
  • Benadryl (diphenhydramine)
  • Fish Oil (omega-3 polyunsaturated fatty acids)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • ibuprofen (Advil, Motrin, IBU, Proprinal, Advil Liqui-Gels, Motrin IB, IBU-200, Nuprin, Advil Infant's Concentrated Drops, Children's Motrin, Advil Children's, Ibu-8, Ibuprofen PMR, Caldolor, Motrin Childrens, Motrin Migraine Pain, Addaprin, Ibu-4, Ibu-Tab, Rufen, Midol IB, A-G Profen, Childrens Ibuprofen Berry, Advil Migraine, Ibu-6, Motrin Infant Drops, NeoProfen, Genpril, Haltran, Menadol, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Motrin Pediatric, Advil Film-Coated)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • metformin (Glucophage, Glumetza, Glucophage XR, Riomet, Fortamet)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • pantoprazole (Protonix, Protonix IV)
  • Prozac (fluoxetine)
  • tramadol (Ultram, Tramadol Hydrochloride ER, Tramal, Ultram ER, Tramedo, GenRx Tramadol, ConZip, Zydol, Ryzolt, Larapam SR, Tramahexal, Zamadol, Tramal SR, Tramahexal SR, Zydol XL, Rybix ODT, Rybix, Ultram ODT)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Tylenol (acetaminophen)
  • Vitamin C (ascorbic acid)
  • Xanax (alprazolam)
  • Zoloft (sertraline)
  • Zyrtec (cetirizine)

Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine) alcohol/food Interactions

There is 1 alcohol/food interaction with Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)

Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine) disease Interactions

There are 15 disease interactions with Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine) which include:

More about Benadryl Allergy Plus Cold (acetaminophen / diphenhydramine / phenylephrine)

Related treatment guides

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide