Skip to Content
Print Share

Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine) Drug Interactions

A total of 935 drugs are known to interact with Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine).

  • 222 major drug interactions
  • 650 moderate drug interactions
  • 63 minor drug interactions

Show all medications in the database that may interact with Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine).

Check for interactions

Type in a drug name to check for interactions with Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine).

Most frequently checked interactions

View interaction reports for Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine) and the medicines listed below.

  • Anti-Diarrheal (loperamide)
  • Atelvia (risedronate)
  • atorvastatin (Lipitor)
  • azithromycin (Zithromax, Azithromycin Dose Pack, Z-Pak, Zmax)
  • baclofen (Lioresal, Gablofen, Lioresal Intrathecal, Kemstro)
  • Benadryl (diphenhydramine)
  • Combivent Respimat (albuterol / ipratropium)
  • Diamode (loperamide)
  • diphenhydramine (Benadryl, Banophen, Benadryl Allergy, ZzzQuil, Sleep, Benadryl Children's Allergy, Diphen, Sominex, Nytol, Diphedryl, Quenalin, Unisom SleepGels, Diphenadryl, Simply Sleep, Dicopanol, Diphenhist, 40 Winks, DPH, Diphenydramine Quick Melt, Hyrexin, Hydramine Cough Syrup, Diphen Cough, Diphenyl, Pharbedryl, Histaprin, Tranquil Nighttime Sleep Aid, Unisom SleepMelts, Dormin, Snooze Fast, Sominex Maximum Strength Caplet, Unisom SleepMinis, Unisom Liquid, Triaminic Thin Strips Allergy, ConRx Allergy, Buckley's Bedtime, Bydramine, Diphen AF, Aler-Dryl, Allergia-C, Benahist-10, Benahist-50, Benoject-50, Calm-Aid, Genahist, Alka-Seltzer Plus Allergy, Q-Dryl, Aller-G-Time, Sleep Tab II, Sleep Tabs, Sleep-Eze-3, Somnicaps, Nytol QuickCaps, Total Allergy, Trux-adryl, Valu-Dryl, Altaryl, Triaminic Thin Strips Cough & Runny Nose, Beldin, Belix, Vicks QlearQuil Nighttime Allergy Relief, Hydramine, Siladryl, Siladryl DAS, Siladyl SA, Silphen Cough, Sleep-ettes, Tusstat, Diphenylin, Hydramine Compound, Pardryl, Nervine, Nu-Med, Nytol Caplet, Compoz Nighttime Sleep Aid, Sleepinal, Help I Can't Sleep, Allermax, Diphendryl, Twilite, Banaril, Aler-Tab, Siladryl Allergy, Theraflu Thin Strips Multi Symptom, Sleep-ettes D, Uni-Tann, Q-Dryl A/F, Diphenmax, Nightime Sleepaid, Ben-Tann, Dytan, Vanamine PD, Z-Sleep, PediaCare Children's Allergy, Truxadryl, Complete Allergy Relief, Dytuss, Miles Nervine, Scot-Tussin Allergy, Sleepwell 2-nite)
  • fenofibric acid (Trilipix, Fibricor)
  • green tea
  • hydroxyzine (Vistaril, Atarax, Hyzine, Vistazine, Rezine)
  • ibuprofen (Advil, Motrin, IBU, Motrin IB, Advil Liqui-Gels, Motrin Childrens, Advil Children's, Caldolor, Children's Motrin, Childrens Ibuprofen Berry, Ibuprofen PMR, Nuprin, NeoProfen, Proprinal, Advil Junior Strength, Midol Maximum Strength Cramp Formula, Advil Migraine, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Advil Infant's Concentrated Drops, Motrin Pediatric, Ibu-Tab, Rufen, Genpril, Haltran, IBU-200, Menadol, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Actiprofen, Motrin Migraine Pain, Addaprin, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, Ibu-8, Motrin Junior Strength, Motrin Infant Drops, Help I Have An Aching Body, Children's ElixSure IB, Cap-Profen, Advil Film-Coated)
  • Ipratropium Inhalation Solution (ipratropium)
  • loperamide (Imodium, Imodium A-D, Anti-Diarrheal, Imotil, Kaopectate II, Neo-Diaral, Pepto Diarrhea Control, Kao-Paverin, Diar-Aid, Diamode, Up and Up Anti-Diarrheal Solution, Kaopectate 1-D, A-D Anti-Diarrheal)
  • Marinol (dronabinol)
  • Metoprolol Tartrate (metoprolol)
  • Mucus Relief Complete (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
  • omeprazole / sodium bicarbonate (Zegerid, Zegerid OTC)
  • ondansetron (Zofran, Zofran ODT, Zuplenz)
  • Tylenol Cold (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine)
  • Tylenol Cold Multi-Symptom Severe (acetaminophen / dextromethorphan / guaifenesin / phenylephrine)
  • Versed (midazolam)

Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine) alcohol/food interactions

There is 1 alcohol/food interaction with Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine)

Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine) disease interactions

There are 10 disease interactions with Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine) which include:

More about Severe Cold Multi-Symptom (acetaminophen / dextromethorphan / pseudoephedrine)

Related treatment guides

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Drugs.com Mobile Apps

The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Available for Android and iOS devices.

Explore Apps
Hide