Acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine Interactions
There are 667 drugs known to interact with acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine, along with 15 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 102 are major, 550 are moderate, and 15 are minor.
- View all 667 medications that may interact with acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine
- View acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine alcohol/food interactions (2)
- View acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine disease interactions (15)
Most frequently checked interactions
View interaction reports for acetaminophen / dextromethorphan / doxylamine / guaifenesin / phenylephrine and the medicines listed below.
- Benadryl (diphenhydramine)
- Biofreeze (menthol topical)
- BuSpar (buspirone)
- CoQ10 (ubiquinone)
- Durezol (difluprednate ophthalmic)
- Eliquis (apixaban)
- Evusheld (cilgavimab / tixagevimab)
- Fish Oil (omega-3 polyunsaturated fatty acids)
- Flomax (tamsulosin)
- Flonase (fluticasone nasal)
- Ginkgo Biloba (ginkgo)
- Lagevrio (molnupiravir)
- Lasix (furosemide)
- Lunesta (eszopiclone)
- Metoprolol Succinate ER (metoprolol)
- Mounjaro (tirzepatide)
- Paxil (paroxetine)
- Prevnar 20 (pneumococcal 20-valent conjugate vaccine)
- Protonix (pantoprazole)
- Valerian Root (valerian)
- Xanax (alprazolam)
- Xarelto (rivaroxaban)
- Zinc (zinc sulfate)
- ZzzQuil (diphenhydramine)
Acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine alcohol/food interactions
There are 2 alcohol/food interactions with acetaminophen / dextromethorphan / doxylamine / guaifenesin / phenylephrine.
Acetaminophen/dextromethorphan/doxylamine/guaifenesin/phenylephrine disease interactions
There are 15 disease interactions with acetaminophen / dextromethorphan / doxylamine / guaifenesin / phenylephrine which include:
- alcoholism
- liver disease
- depression
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- glaucoma
- liver disease
- resp depression
- BPH
- diabetes
- glaucoma
Report options
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.