Co-Apap Interactions
There are 691 drugs known to interact with Co-Apap (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine), along with 13 disease interactions, and 2 alcohol/food interactions. Of the total drug interactions, 103 are major, 568 are moderate, and 20 are minor.
- View Co-Apap alcohol/food interactions (2)
- View Co-Apap disease interactions (13)
Medications known to interact with Co-Apap
Note: Showing generic names only.
- abametapir topical
- abiraterone
- abobotulinumtoxinA
- acarbose
- acebutolol
- acetohexamide
- acetylcarbromal
- acetylcholine ophthalmic
- aclidinium
- acrivastine
- adagrasib
- adalimumab
- albiglutide
- albuterol
- alefacept
- alfentanil
- alfuzosin
- allopurinol
- almotriptan
- alogliptin
- alprazolam
- amantadine
- amifampridine
- aminophylline
- amiodarone
- amisulpride
- amitriptyline
- ammonium chloride
- amobarbital
- amoxapine
- amphetamine
- anagrelide
- anakinra
- anisindione
- apalutamide
- apomorphine
- apraclonidine ophthalmic
- arformoterol
- aripiprazole
- armodafinil
- ascorbic acid
- asenapine
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atenolol
- atezolizumab
- atomoxetine
- atropine
- avelumab
- azatadine
- azelastine nasal
- baclofen
- bedaquiline
- belladonna
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzphetamine
- benztropine
- berotralstat
- betaxolol
- bexagliflozin
- bimekizumab
- biperiden
- bisoprolol
- bitolterol
- black cohosh
- brentuximab
- brexanolone
- brexpiprazole
- brimonidine ophthalmic
- brimonidine topical
- brivaracetam
- brodalumab
- bromocriptine
- brompheniramine
- bupivacaine
- bupivacaine liposome
- buprenorphine
- bupropion
- buspirone
- busulfan
- butabarbital
- butalbital
- butorphanol
- caffeine
- calaspargase pegol
- canagliflozin
- canakinumab
- cannabidiol
- cannabis
- capivasertib
- carbachol ophthalmic
- carbamazepine
- carbetapentane
- carbinoxamine
- cariprazine
- carisoprodol
- carvedilol
- celecoxib
- cemiplimab
- cenobamate
- ceritinib
- cetirizine
- charcoal
- chlophedianol
- chloral hydrate
- chlorcyclizine
- chlordiazepoxide
- chlormezanone
- chloroprocaine
- chloroprocaine ophthalmic
- chlorphenesin
- chlorpromazine
- chlorpropamide
- chlorzoxazone
- cholestyramine
- cimetidine
- cinacalcet
- citalopram
- clemastine
- clidinium
- clobazam
- clofarabine
- clomipramine
- clonazepam
- clonidine
- clorazepate
- clozapine
- cobicistat
- cocaine nasal
- cocaine topical
- codeine
- cosibelimab
- cyclizine
- cyclobenzaprine
- cyproheptadine
- daclizumab
- dacomitinib
- danicopan
- dantrolene
- dapagliflozin
- daridorexant
- darifenacin
- daxibotulinumtoxinA
- deferasirox
- delavirdine
- demecarium bromide ophthalmic
- deserpidine
- desflurane
- desipramine
- desvenlafaxine
- deutetrabenazine
- dexbrompheniramine
- dexchlorpheniramine
- dexfenfluramine
- dexmedetomidine
- dexmethylphenidate
- dextroamphetamine
- dezocine
- diazepam
- dibucaine topical
- dicumarol
- dicyclomine
- diethylpropion
- difelikefalin
- diflunisal
- digitoxin
- digoxin
- dihydroergotamine
- dimenhydrinate
- diphenhydramine
- disopyramide
- divalproex sodium
- dobutamine
- dolasetron
- donepezil
- dopamine
- dostarlimab
- doxapram
- doxazosin
- doxepin
- doxepin topical
- doxylamine
- dronabinol
- dronedarone
- droperidol
- droxidopa
- dulaglutide
- duloxetine
- durvalumab
- echinacea
- echothiophate iodide ophthalmic
- efavirenz
- elacestrant
- eletriptan
- eliglustat
- eluxadoline
- emapalumab
- empagliflozin
- encorafenib
- enflurane
- entacapone
- epcoritamab
- ephedrine
- epinephrine
- epirubicin
- epoprostenol
- ergonovine
- ergotamine
- ertugliflozin
- escitalopram
- esketamine
- eslicarbazepine
- esmolol
- estazolam
- eszopiclone
- ethanol
- ethchlorvynol
- ethinyl estradiol
- ethosuximide
- ethotoin
- etidocaine
- etranacogene dezaparvovec
- evening primrose
- exenatide
- ezogabine
- fedratinib
- felbamate
- fenfluramine
- fenofibrate
- fenoldopam
- fentanyl
- fesoterodine
- fexinidazole
- fidanacogene elaparvovec
- flavoxate
- flibanserin
- fluoxetine
- fluphenazine
- flurazepam
- fluvoxamine
- formoterol
- fosphenytoin
- fostamatinib
- frovatriptan
- furazolidone
- gabapentin
- gabapentin enacarbil
- galantamine
- ganaxolone
- gepirone
- ginkgo
- givosiran
- glimepiride
- glipizide
- glofitamab
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- glycopyrronium topical
- golimumab
- granisetron
- guanadrel
- guanethidine
- guanfacine
- guselkumab
- halazepam
- halofantrine
- haloperidol
- halothane
- heroin
- histamine phosphate
- house dust mite allergen extract
- hyaluronidase
- hydrocodone
- hydromorphone
- hydroxychloroquine
- hydroxyprogesterone
- hydroxyzine
- hyoscyamine
- idelalisib
- ifosfamide
- iloperidone
- iloprost
- imatinib
- imipramine
- incobotulinumtoxinA
- indacaterol
- infliximab
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iobenguane I 123
- iobenguane I 131
- iohexol
- iomeprol
- iopamidol
- ipilimumab
- ipratropium
- ipratropium nasal
- isocarboxazid
- isoetharine
- isoflurane
- isoflurophate ophthalmic
- isoniazid
- isoproterenol
- labetalol
- lamotrigine
- landiolol
- lasmiditan
- leflunomide
- lemborexant
- lenacapavir
- leniolisib
- letibotulinumtoxinA
- levalbuterol
- levetiracetam
- levobupivacaine
- levocetirizine
- levodopa
- levoketoconazole
- levomethadyl acetate
- levomilnacipran
- levorphanol
- levothyroxine
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- linagliptin
- lindane topical
- linezolid
- liothyronine
- liraglutide
- lisdexamfetamine
- lithium
- lixisenatide
- lofexidine
- lomitapide
- lonapegsomatropin
- loperamide
- lorazepam
- lorcaserin
- lorlatinib
- loxapine
- lumateperone
- lurasidone
- ma huang
- maprotiline
- mavorixafor
- mazindol
- mecamylamine
- meclizine
- melatonin
- memantine
- mepenzolate
- meperidine
- mephentermine
- mephenytoin
- mephobarbital
- mepivacaine
- meprobamate
- mesoridazine
- metaproterenol
- metaraminol
- metaxalone
- metformin
- methadone
- methamphetamine
- methdilazine
- methionine
- methocarbamol
- methohexital
- methotrexate
- methotrimeprazine
- methoxamine
- methoxyflurane
- methscopolamine
- methsuximide
- methyldopa
- methylene blue
- methylergonovine
- methylphenidate
- methysergide maleate
- metoclopramide
- metoprolol
- metrizamide
- metyrosine
- mibefradil
- midazolam
- midodrine
- miglitol
- milnacipran
- mipomersen
- mirabegron
- mirtazapine
- mitotane
- mixed grass pollens allergen extract
- modafinil
- molindone
- morphine
- morphine liposomal
- nabilone
- nadolol
- nalbuphine
- naltrexone
- naratriptan
- nateglinide
- nebivolol
- nefazodone
- nemolizumab
- nicotine
- nilotinib
- niraparib
- nivolumab
- norepinephrine
- nortriptyline
- olanzapine
- oliceridine
- olodaterol
- olopatadine nasal
- olutasidenib
- omaveloxolone
- onabotulinumtoxinA
- ondansetron
- opicapone
- opium
- oritavancin
- orphenadrine
- osilodrostat
- ospemifene
- oxamniquine
- oxazepam
- oxcarbazepine
- oxybutynin
- oxycodone
- oxymorphone
- oxytocin
- ozanimod
- paliperidone
- palonosetron
- panobinostat
- paraldehyde
- paramethadione
- paroxetine
- peanut allergen powder
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pentazocine
- pentobarbital
- perampanel
- pergolide
- perphenazine
- pexidartinib
- phenacemide
- phendimetrazine
- phenelzine
- phenindamine
- phenobarbital
- phenoxybenzamine
- phensuximide
- phentermine
- phentolamine
- phenylephrine
- phenylpropanolamine
- phenytoin
- physostigmine
- physostigmine ophthalmic
- pilocarpine ophthalmic
- pimozide
- pindolol
- pioglitazone
- pirbuterol
- pirtobrutinib
- pitolisant
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- potassium acid phosphate
- potassium chloride
- potassium citrate
- prabotulinumtoxinA
- pralsetinib
- pramipexole
- pramlintide
- pramoxine topical
- prazosin
- pregabalin
- pretomanid
- primidone
- probenecid
- procainamide
- procaine
- procarbazine
- prochlorperazine
- procyclidine
- promazine
- promethazine
- propafenone
- propantheline
- proparacaine ophthalmic
- propiomazine
- propoxyphene
- propranolol
- protriptyline
- pyrilamine
- racepinephrine
- ragweed pollen allergen extract
- ramelteon
- ranitidine
- ranitidine bismuth citrate
- ranolazine
- rasagiline
- rauwolfia serpentina
- remdesivir
- remifentanil
- remimazolam
- repaglinide
- reserpine
- retifanlimab
- revefenacin
- rifampin
- rilonacept
- rimabotulinumtoxinB
- risperidone
- ritlecitinib
- ritodrine
- ritonavir
- rivastigmine
- rizatriptan
- rolapitant
- ropeginterferon alfa-2b
- ropinirole
- ropivacaine
- rosiglitazone
- rotigotine
- rucaparib
- rufinamide
- safinamide
- salmeterol
- sarilumab
- satralizumab
- saxagliptin
- scopolamine
- secobarbital
- secukinumab
- selegiline
- selexipag
- semaglutide
- sertraline
- sevoflurane
- sibutramine
- silodosin
- siltuximab
- sitagliptin
- sodium acetate
- sodium bicarbonate
- sodium citrate
- sodium iodide i-123
- sodium iodide-i-131
- sodium lactate
- sodium oxybate
- sodium salicylate
- solifenacin
- solriamfetol
- somapacitan-beco
- somatrem
- somatrogon
- somatropin
- sotagliflozin
- sotalol
- st. john's wort
- stiripentol
- sufentanil
- sulfinpyrazone
- sumatriptan
- suvorexant
- tacrine
- tafamidis
- tamsulosin
- tapentadol
- tarlatamab
- tasimelteon
- tebentafusp
- teclistamab
- tedizolid
- temazepam
- terazosin
- terbinafine
- terbutaline
- teriflunomide
- tetrabenazine
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- thalidomide
- theophylline
- thiethylperazine
- thioguanine
- thiopental
- thioridazine
- thiothixene
- thyroid desiccated
- tiagabine
- ticlopidine
- timolol
- timolol ophthalmic
- timothy grass pollen allergen extract
- tiotropium
- tirzepatide
- tislelizumab
- tizanidine
- tocilizumab
- tolazamide
- tolazoline
- tolbutamide
- tolcapone
- tolterodine
- topiramate
- toripalimab
- trabectedin
- tramadol
- tranylcypromine
- trazodone
- tremelimumab
- treprostinil
- triazolam
- trichophyton skin test
- trifluoperazine
- triflupromazine
- trihexyphenidyl
- trimeprazine
- trimethadione
- trimethobenzamide
- trimipramine
- tripelennamine
- triprolidine
- troglitazone
- tromethamine
- trospium
- tryptophan
- valbenazine
- valdecoxib
- valerian
- valoctocogene roxaparvovec
- valproic acid
- varenicline
- vemurafenib
- venlafaxine
- vigabatrin
- vilazodone
- viloxazine
- vimseltinib
- vortioxetine
Co-Apap alcohol/food interactions
There are 2 alcohol/food interactions with Co-Apap (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine).
Co-Apap disease interactions
There are 13 disease interactions with Co-Apap (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine) which include:
- alcoholism
- liver disease
- cardiovascular disease
- PKU
- anticholinergic effects
- asthma/COPD
- cardiovascular
- renal/liver disease
- GI narrowing
- PKU
- BPH
- diabetes
- glaucoma
More about Co-Apap (acetaminophen / chlorpheniramine / dextromethorphan / pseudoephedrine)
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
See also:
Benadryl
Benadryl is an antihistamine and is used to treat sneezing, runny nose, itching and other ...
Promethazine DM
Promethazine DM is used for allergic rhinitis, cold symptoms, cough
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Banophen
Banophen is used for allergic reactions, allergic rhinitis, cold symptoms, cough, extrapyramidal ...
Benadryl Allergy
Benadryl Allergy is used for allergic reactions, allergic rhinitis, allergies, cold symptoms ...
Pseudoephedrine/triprolidine
Pseudoephedrine/triprolidine systemic is used for allergic rhinitis, cold symptoms
Echinacea
Echinacea systemic is used for cold symptoms, condylomata acuminata, herbal supplementation
Chlorpheniramine
Chlorpheniramine systemic is used for allergic reactions, allergic rhinitis, allergies, cold ...
Diphenhydramine
Diphenhydramine is an antihistamine used to treat sneezing, runny nose, itching, hives and other ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.