Medique Pain-Off Interactions
There are 579 drugs known to interact with Medique Pain-Off (acetaminophen / aspirin / caffeine), along with 21 disease interactions, and 6 alcohol/food interactions. Of the total drug interactions, 72 are major, 433 are moderate, and 74 are minor.
- View Medique Pain-Off alcohol/food interactions (6)
- View Medique Pain-Off disease interactions (21)
Medications known to interact with Medique Pain-Off
Note: Showing generic names only.
A
- abametapir topical
- abciximab
- abrocitinib
- acalabrutinib
- acebutolol
- acetazolamide
- acetohexamide
- adenosine
- ado-trastuzumab emtansine
- aducanumab
- albuterol
- alemtuzumab
- alendronate
- aliskiren
- allopurinol
- alosetron
- alteplase
- aluminum carbonate
- aluminum hydroxide
- ambenonium
- amikacin
- amikacin liposome
- amiloride
- aminophylline
- amlodipine
- amobarbital
- amphetamine
- anacaulase topical
- anagrelide
- anisindione
- anistreplase
- apalutamide
- apixaban
- ardeparin
- arformoterol
- argatroban
- armodafinil
- asparaginase erwinia chrysanthemi
- asparaginase escherichia coli
- atazanavir
- atenolol
- atezolizumab
- atomoxetine
- atropine
- avapritinib
- avelumab
- azilsartan medoxomil
B
- baricitinib
- bedaquiline
- belladonna
- benazepril
- bendamustine
- bendroflumethiazide
- benoxinate ophthalmic
- benzgalantamine
- benzocaine topical
- benzphetamine
- benzthiazide
- benztropine
- bepridil
- betamethasone
- betaxolol
- betiatide
- betrixaban
- biperiden
- bismuth subsalicylate
- bisoprolol
- bitolterol
- black cohosh
- brentuximab
- brinzolamide ophthalmic
- bromfenac
- bromfenac ophthalmic
- budesonide
- bumetanide
- bupivacaine
- bupivacaine liposome
- bupropion
- busulfan
- butabarbital
- butalbital
C
- cabozantinib
- calaspargase pegol
- calcium carbonate
- candesartan
- cannabidiol
- caplacizumab
- capmatinib
- capsicum
- captopril
- carbamazepine
- carteolol
- carvedilol
- celecoxib
- cemiplimab
- ceritinib
- chamomile
- charcoal
- chloroprocaine
- chloroprocaine ophthalmic
- chlorothiazide
- chlorpropamide
- chlorthalidone
- cholestyramine
- choline salicylate
- cilostazol
- cimetidine
- cinoxacin
- ciprofloxacin
- citalopram
- clidinium
- clofarabine
- clomipramine
- clopidogrel
- clove
- clozapine
- cocaine nasal
- cocaine topical
- collagenase clostridium histolyticum
- cortisone
- cosibelimab
- cycloserine
- cyclosporine
D
- dabigatran
- daclizumab
- dalteparin
- danaparoid
- daprodustat
- darifenacin
- dasatinib
- deferasirox
- defibrotide
- deflazacort
- delafloxacin
- deoxycholic acid
- desirudin
- desmopressin
- desvenlafaxine
- dexamethasone
- dexfenfluramine
- dexlansoprazole
- dexmethylphenidate
- dextroamphetamine
- diazepam
- dibucaine topical
- dichlorphenamide
- diclofenac
- diclofenac ophthalmic
- diclofenac topical
- dicumarol
- dicyclomine
- didanosine
- diethylpropion
- diflunisal
- digoxin
- dihydroxyaluminum sodium carbonate
- diltiazem
- dimethyl fumarate
- dipyridamole
- diroximel fumarate
- disulfiram
- divalproex sodium
- dobutamine
- donanemab
- donepezil
- dong quai
- dopamine
- dorzolamide ophthalmic
- dostarlimab
- doxapram
- drospirenone
- drotrecogin alfa
- duloxetine
- durvalumab
E
- echinacea
- edoxaban
- edrophonium
- efavirenz
- enalapril
- enalaprilat
- encorafenib
- enoxacin
- enoxaparin
- ephedrine
- epinephrine
- epirubicin
- eplerenone
- epoprostenol
- eprosartan
- eptifibatide
- erlotinib
- escitalopram
- esketamine
- esmolol
- esomeprazole
- ethacrynic acid
- ethanol
- ethinyl estradiol
- ethotoin
- etidocaine
- etidronate
- etodolac
- etranacogene dezaparvovec
- evening primrose
F
- felodipine
- fenfluramine
- fenofibrate
- fenoldopam
- fenoprofen
- fenugreek
- feverfew
- fexinidazole
- fezolinetant
- fidanacogene elaparvovec
- flavoxate
- fludrocortisone
- fluoxetine
- flurbiprofen
- flurbiprofen ophthalmic
- fluvoxamine
- fondaparinux
- formoterol
- fosinopril
- fosphenytoin
- furosemide
G
- garlic
- gatifloxacin
- gemifloxacin
- gentamicin
- ginger
- ginkgo
- ginseng
- givosiran
- glimepiride
- glipizide
- glyburide
- glycerol phenylbutyrate
- glycopyrrolate
- grepafloxacin
- griseofulvin
H
- hemin
- heparin
- heparin flush
- horse chestnut
- hyaluronidase
- hydralazine
- hydrochlorothiazide
- hydrocortisone
- hydroflumethiazide
- hydroxyprogesterone
- hyoscyamine
I
- ibandronate
- ibritumomab
- ibrutinib
- ibuprofen
- icosapent
- idelalisib
- iloprost
- imatinib
- imipramine
- indacaterol
- indapamide
- indomethacin
- influenza virus vaccine, h1n1, live
- influenza virus vaccine, live
- inotersen
- insulin
- insulin aspart
- insulin aspart protamine
- insulin degludec
- insulin detemir
- insulin glargine
- insulin glulisine
- insulin inhalation, rapid acting
- insulin isophane
- insulin lispro
- insulin lispro protamine
- insulin regular
- insulin zinc
- insulin zinc extended
- interferon beta-1a
- interferon beta-1b
- iodine i 131 tositumomab
- ipilimumab
- irbesartan
- isoetharine
- isoniazid
- isoproterenol
- isradipine
K
L
- labetalol
- lansoprazole
- lecanemab
- leflunomide
- leniolisib
- lepirudin
- lesinurad
- levalbuterol
- levamlodipine
- levobupivacaine
- levofloxacin
- levoketoconazole
- levomilnacipran
- lidocaine
- lidocaine ophthalmic
- lidocaine otic
- lidocaine topical
- liraglutide
- lisdexamfetamine
- lisinopril
- lithium
- lomefloxacin
- lomitapide
- lorlatinib
- losartan
M
- ma huang
- macimorelin
- magaldrate
- magnesium carbonate
- magnesium hydroxide
- magnesium oxide
- magnesium salicylate
- mavorixafor
- mazindol
- meclofenamate
- mefenamic acid
- melatonin
- meloxicam
- mepenzolate
- mephentermine
- mephenytoin
- mephobarbital
- mepivacaine
- metaproterenol
- metaraminol
- methamphetamine
- methazolamide
- methohexital
- methotrexate
- methoxamine
- methscopolamine
- methyclothiazide
- methylphenidate
- methylprednisolone
- metoclopramide
- metolazone
- metoprolol
- mibefradil
- mifepristone
- milnacipran
- mipomersen
- modafinil
- moexipril
- monomethyl fumarate
- moxifloxacin
N
- nabumetone
- nadolol
- nalidixic acid
- naltrexone
- naproxen
- nateglinide
- nebivolol
- nepafenac ophthalmic
- netilmicin
- niacin
- nicardipine
- nicotinamide
- nicotine
- nifedipine
- nimodipine
- nintedanib
- niraparib
- nisoldipine
- nitroglycerin
- nivolumab
- norepinephrine
- norfloxacin
O
- obeticholic acid
- ofloxacin
- olaparib
- olmesartan
- olodaterol
- olutasidenib
- omacetaxine
- omaveloxolone
- omega-3 polyunsaturated fatty acids
- omeprazole
- osilodrostat
- osimertinib
- ospemifene
- oxaprozin
- oxazepam
- oxybutynin
P
- pacritinib
- pamidronate
- panobinostat
- pantoprazole
- paroxetine
- pegaspargase
- peginterferon beta-1a
- pembrolizumab
- pemetrexed
- penbutolol
- pentobarbital
- pentosan polysulfate sodium
- pentoxifylline
- perindopril
- pexidartinib
- phendimetrazine
- phenobarbital
- phentermine
- phenylbutazone
- phenylephrine
- phenylpropanolamine
- phenytoin
- pimozide
- pindolol
- pirbuterol
- piroxicam
- pirtobrutinib
- pitolisant
- plasminogen, human
- plazomicin
- pneumococcal 13-valent vaccine
- pneumococcal 15-valent conjugate vaccine
- pneumococcal 20-valent conjugate vaccine
- pneumococcal 21-valent conjugate vaccine
- pneumococcal 7-valent vaccine
- polyethylene glycol 3350 with electrolytes
- polythiazide
- ponatinib
- potassium citrate
- pralatrexate
- pralsetinib
- pramoxine topical
- prasugrel
- prazosin
- prednisolone
- prednisone
- primidone
- probenecid
- procaine
- procyclidine
- propantheline
- proparacaine ophthalmic
- propranolol
- pseudoephedrine
- pyridostigmine
Q
R
- rabeprazole
- racepinephrine
- ramelteon
- ramipril
- ramucirumab
- ranitidine
- ranitidine bismuth citrate
- rasagiline
- regadenoson
- regorafenib
- remdesivir
- repaglinide
- reteplase
- retifanlimab
- rifampin
- riluzole
- riociguat
- risedronate
- ritlecitinib
- ritodrine
- rivaroxaban
- rivastigmine
- rofecoxib
- ropinirole
- ropivacaine
- rucaparib
S
- salmeterol
- salsalate
- scopolamine
- secobarbital
- selumetinib
- sertraline
- sibutramine
- sodium acetate
- sodium bicarbonate
- sodium citrate
- sodium iodide i-123
- sodium iodide-i-131
- sodium lactate
- sodium salicylate
- sodium thiosalicylate
- solifenacin
- sotalol
- sparfloxacin
- sparsentan
- spironolactone
- stiripentol
- streptokinase
- streptomycin
- sulfinpyrazone
- sulindac
- suprofen ophthalmic
T
- tacrine
- tafamidis
- tafasitamab
- telmisartan
- tenecteplase
- terbinafine
- terbutaline
- teriflunomide
- tetracaine
- tetracaine ophthalmic
- tetracaine topical
- theophylline
- thiabendazole
- thioguanine
- thiopental
- ticagrelor
- ticlopidine
- tiludronate
- timolol
- tinzaparin
- tipranavir
- tirofiban
- tirzepatide
- tislelizumab
- tizanidine
- tobramycin
- tofacitinib
- tolazamide
- tolbutamide
- tolmetin
- tolterodine
- topotecan
- toripalimab
- torsemide
- tositumomab
- tovorafenib
- trabectedin
- trandolapril
- tremelimumab
- treprostinil
- triamcinolone
- triamcinolone ophthalmic
- triamterene
- trichlormethiazide
- trihexyphenidyl
- tromethamine
- trospium
- trovafloxacin
- turmeric
U
V
- vadadustat
- valdecoxib
- valoctocogene roxaparvovec
- valproic acid
- valsartan
- vamorolone
- varenicline
- varicella virus vaccine
- vemurafenib
- venlafaxine
- verapamil
- verteporfin
- vilazodone
- viloxazine
- vitamin e
- voclosporin
- vortioxetine
W
Z
Medique Pain-Off alcohol/food interactions
There are 6 alcohol/food interactions with Medique Pain-Off (acetaminophen / aspirin / caffeine).
Medique Pain-Off disease interactions
There are 21 disease interactions with Medique Pain-Off (acetaminophen / aspirin / caffeine) which include:
- alcoholism
- liver disease
- coagulation
- cardiac disease
- hypertension
- psychiatric disorders
- PUD
- asthma
- GI toxicity
- renal dysfunction
- Reye's syndrome
- PKU
- cardiotoxicity
- liver disease
- renal dysfunction
- seizure disorders
- GERD
- anemia
- dialysis
- G-6-PD deficiency
- hepatotoxicity
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More about Medique Pain-Off (acetaminophen / aspirin / caffeine)
- Compare alternatives
- Reviews (1)
- Latest FDA alerts (4)
- Side effects
- Dosage information
- During pregnancy
- Drug class: analgesic combinations
Related treatment guides
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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