Vorapaxar Dosage

Medically reviewed by Drugs.com. Last updated on Dec 6, 2023.

Usual Adult Dose for Thromboembolic Disorder

2.08 mg orally once a day, with or without food

Comments: Use with aspirin and/or clopidogrel

Uses: For reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD)

Usual Adult Dose for Peripheral Arterial Disease

2.08 mg orally once a day, with or without food

Comments: Use with aspirin and/or clopidogrel

Uses: For reduction of thrombotic cardiovascular events in patients with a history of myocardial infarction (MI) or with peripheral arterial disease (PAD)

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

Mild and moderate hepatic impairment: No adjustment recommended.
Severe hepatic impairment: Not recommended.

Precautions

US BOXED WARNING:

• BLEEDING RISK: Do not use vorapaxar in patients with a history of stroke, transient ischemic attack, intracranial hemorrhage (ICH), or active pathological bleeding. Antiplatelet agents, including this drug, increase the risk of bleeding, including ICH and fatal bleeding.

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• Administer with or without food.
• Use this drug with aspirin and/or clopidogrel according to indications or standard of care.

Patient advice:

• This drug should not be discontinued without physician advice.
• Report any unanticipated, prolonged or excessive bleeding, or blood in stool or urine.
• Inform physicians and dentists that you are taking this drug before any surgery or dental procedure.
• Advise patients that breastfeeding is not recommended during treatment with this drug.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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