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Protease-activated receptor-1 antagonists

What are Protease-activated receptor-1 antagonists

Protease-activated receptor-1 (PAR 1) antagonists have an antiplatelet effect by inhibiting thrombin-related platelet aggregation.

Thrombin's cellular effects are mediated by PARs therefore the action of the PAR 1 antagonists alters signalling in platelets and interferes with platelet activation.

PAR 1 antagonists are used to reduce the risk of thrombotic cardiovascular events in patients who have an increased risk of myocardial infarction or peripheral arterial disease.

List of Protease-activated receptor-1 antagonists:

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Zontivity (Pro, More...)
generic name: vorapaxar
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Medical conditions associated with protease-activated receptor-1 antagonists:

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