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Vorapaxar Side Effects

For the Consumer

Applies to vorapaxar: oral tablet

As well as its needed effects, vorapaxar may cause unwanted side effects that require medical attention.

Major Side Effects

If any of the following side effects occur while taking vorapaxar, check with your doctor immediately:

Less common:
  • Bloody or black, tarry stools
  • constipation
  • pale skin
  • severe stomach pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds
  • Confusion
  • headache, sudden and severe
  • nausea and vomiting
  • weakness

Minor Side Effects

Some vorapaxar side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rashes
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to vorapaxar: oral tablet


Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.[Ref]


Very common (10% or more): Bleeding
Common (1% to 10%): Anemia, iron deficiency[Ref]


Common (1% to 10%): Rashes, eruptions, exanthemas[Ref]


Common (1% to 10%): Gastrointestinal bleeding[Ref]


Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances[Ref]

Nervous system

Uncommon (0.1% to 1%): Intracranial bleeding[Ref]


1. "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.

It is possible that some side effects of vorapaxar may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.