Vorapaxar Side Effects

Medically reviewed by Drugs.com. Last updated on Nov 6, 2024.

Applies to vorapaxar: oral tablet.

Important warnings This medicine can cause some serious health issues

Oral route (tablet)

Antiplatelet agents increase the risk of bleeding, including intracranial hemorrhage (ICH) and fatal bleeding.

Do not use vorapaxar in patients with active pathological bleeding or a history of stroke, TIA, or ICH.

Serious side effects of vorapaxar

Along with its needed effects, vorapaxar may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorapaxar:

Less common side effects

• bloody or black, tarry stools
• constipation
• pale skin
• severe stomach pain
• troubled breathing with exertion
• unusual bleeding or bruising
• unusual tiredness or weakness
• vomiting of blood or material that looks like coffee grounds

Rare side effects

• confusion
• headache, sudden and severe
• nausea and vomiting
• weakness

Other side effects of vorapaxar

Some side effects of vorapaxar may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common side effects

• discouragement
• feeling sad or empty
• irritability
• lack of appetite
• loss of interest or pleasure
• rashes
• trouble concentrating
• trouble sleeping

For healthcare professionals

Applies to vorapaxar: oral tablet.

General adverse events

Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.^[Ref]

Hematologic

• Very common (10% or more): Bleeding
• Common (1% to 10%): Anemia, iron deficiency^[Ref]

Dermatologic

• Common (1% to 10%): Rashes, eruptions, exanthemas^[Ref]

Gastrointestinal

• Common (1% to 10%): Gastrointestinal bleeding^[Ref]

Ocular

• Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances^[Ref]

Nervous system

• Uncommon (0.1% to 1%): Intracranial bleeding^[Ref]

Further information

Vorapaxar side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer