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Vorapaxar Side Effects

In Summary

Commonly reported side effects of vorapaxar include: hemorrhage. Other side effects include: anemia and gastrointestinal hemorrhage. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to vorapaxar: oral tablet

Along with its needed effects, vorapaxar may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking vorapaxar:

Less common
  • Bloody or black, tarry stools
  • constipation
  • pale skin
  • severe stomach pain
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood or material that looks like coffee grounds

Some side effects of vorapaxar may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rashes
  • trouble concentrating
  • trouble sleeping

For Healthcare Professionals

Applies to vorapaxar: oral tablet


Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.[Ref]


Very common (10% or more): Bleeding
Common (1% to 10%): Anemia, iron deficiency[Ref]


Common (1% to 10%): Rashes, eruptions, exanthemas[Ref]


Common (1% to 10%): Gastrointestinal bleeding[Ref]


Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances[Ref]

Nervous system

Uncommon (0.1% to 1%): Intracranial bleeding[Ref]


1. "Product Information. Zontivity (vorapaxar)." Merck & Company Inc, Whitehouse Station, NJ.

Some side effects of vorapaxar may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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