Vorapaxar Side Effects
Medically reviewed by Drugs.com. Last updated on Sep 1, 2023.
Applies to vorapaxar: oral tablet.
Warning
Oral route (Tablet)
Antiplatelet agents increase the risk of bleeding, including intracranial hemorrhage (ICH) and fatal bleeding. Do not use vorapaxar in patients with active pathological bleeding or a history of stroke, TIA, or ICH.
Serious side effects of Vorapaxar
Along with its needed effects, vorapaxar may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking vorapaxar:
Less common
- Bloody or black, tarry stools
- constipation
- pale skin
- severe stomach pain
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
Rare
Other side effects of Vorapaxar
Some side effects of vorapaxar may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
- Discouragement
- feeling sad or empty
- irritability
- lack of appetite
- loss of interest or pleasure
- rashes
- trouble concentrating
- trouble sleeping
For Healthcare Professionals
Applies to vorapaxar: oral tablet.
General
Bleeding, including life-threatening and fatal bleeding, is the most commonly reported adverse reaction.[Ref]
Hematologic
Very common (10% or more): Bleeding
Common (1% to 10%): Anemia, iron deficiency[Ref]
Dermatologic
Common (1% to 10%): Rashes, eruptions, exanthemas[Ref]
Gastrointestinal
Common (1% to 10%): Gastrointestinal bleeding[Ref]
Ocular
Common (1% to 10%): Retinopathy or retinal disorder, diplopia/oculomotor disturbances[Ref]
Nervous system
Uncommon (0.1% to 1%): Intracranial bleeding[Ref]
More about vorapaxar
- Check interactions
- Compare alternatives
- Dosage information
- During pregnancy
- Drug class: protease-activated receptor-1 antagonists
- En español
Patient resources
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Professional resources
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Related treatment guides
References
1. Product Information. Zontivity (vorapaxar). Merck & Co., Inc. 2014.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.
