vorapaxar (Oral route)
Antiplatelet agents increase the risk of bleeding, including intracranial hemorrhage (ICH) and fatal bleeding. Do not use vorapaxar in patients with active pathological bleeding or a history of stroke, TIA, or ICH .
Commonly used brand name(s)
In the U.S.
Available Dosage Forms:
Therapeutic Class: Platelet Aggregation Inhibitor
Uses For vorapaxar
Vorapaxar is used to lower risk of having blood clots in patients with a history of heart attack or with reduced blow flow in their legs.
vorapaxar is available only with your doctor's prescription.
Before Using vorapaxar
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For vorapaxar, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to vorapaxar or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of vorapaxar in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of vorapaxar in the elderly. However, elderly patients are more likely to have bleeding problems, which may require caution in patients receiving vorapaxar.
|All Trimesters||B||Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with Medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking vorapaxar, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using vorapaxar with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
Using vorapaxar with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Amtolmetin Guacil
- Choline Salicylate
- Dabigatran Etexilate
- Flufenamic Acid
- Mefenamic Acid
- Niflumic Acid
- Nimesulide Beta Cyclodextrin
- Protein C
- Salicylic Acid
- Sodium Salicylate
- St John's Wort
- Tiaprofenic Acid
- Tolfenamic Acid
Interactions with Food/Tobacco/Alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of vorapaxar. Make sure you tell your doctor if you have any other medical problems, especially:
- Bleeding, active or
- Stroke, history of or
- Transient ischemic attack, history of—Should not be used in patients with these conditions.
- Bleeding problems, history of or
- Hypotension (low blood pressure) or
- Kidney problems or
- Liver problems or
- Low body weight or
- Medical procedures (eg, coronary angiography, percutaneous coronary intervention), recent or
- Surgery (eg, coronary artery bypass graft surgery [CABG]), recent—May increase risk for bleeding problems.
- Liver disease, severe—Use is not recommended in patients with this condition.
Proper Use of vorapaxar
Take vorapaxar exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.
vorapaxar should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.
You may take vorapaxar with or without food.
You may take vorapaxar with aspirin or clopidogrel as prescribed by your doctor.
The dose of vorapaxar will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of vorapaxar. If your dose is different, do not change it unless your doctor tells you to do so.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
- For oral dosage form (tablets):
- To lower risk of blood clots:
- Adults—2.08 milligrams (mg) once a day.
- Children—Use and dose must be determined by your doctor.
- To lower risk of blood clots:
If you miss a dose of vorapaxar, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children.
Do not keep outdated medicine or medicine no longer needed.
Ask your healthcare professional how you should dispose of any medicine you do not use.
Precautions While Using vorapaxar
It is very important that your doctor check your progress at regular visits to make sure that vorapaxar is working properly. Blood tests may be needed to check for unwanted effects.
vorapaxar may increase your risk of serious bleeding problems. Call your doctor right away if you have bleeding that is severe or that you cannot control, coughing up blood, pink, red, or brown urine, red or black stools, or vomiting blood or material that looks like coffee grounds.
vorapaxar can cause you to bleed and bruise more easily. Take precautions to avoid injury. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
Do not stop taking vorapaxar without checking first with your doctor.
Make sure any doctor or dentist who treats you knows that you are using vorapaxar. You may need to stop using vorapaxar several days before having surgery.
Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.
vorapaxar Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:Less common
- Bloody or black, tarry stools
- pale skin
- severe stomach pain
- troubled breathing with exertion
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood or material that looks like coffee grounds
- headache, sudden and severe
- nausea and vomiting
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:Less common
- feeling sad or empty
- lack of appetite
- loss of interest or pleasure
- trouble concentrating
- trouble sleeping
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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More about vorapaxar
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
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- Drug class: protease-activated receptor-1 antagonists
Other brands: Zontivity