Applies to the following strength(s): 100 mg ; 200 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Parkinson's Disease
100 mg orally three times daily, always taken together with the first dose of the day of levodopa/carbidopa.
Renal Dose Adjustments
CrCl less than 25 mL/min: not recommended
Liver Dose Adjustments
Clearance and volume of distribution of unbound tolcapone was reduced by almost 50% in patients with moderate cirrhotic liver disease (Child-Pugh Class B). This change may increase the average serum concentration of unbound drug by twofold.
The dose may be increased to 200 mg three times daily only if the anticipated incremental benefit is justified. If the patient fails to show substantial clinical benefit within 3 weeks of start of tolcapone, tolcapone should be discontinued.
If the daily of dose of levodopa exceed 600 mg or if patient had moderate or severe dyskinesia, a decrease in dose may be warranted.
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age). There is no identified potential use of tolcapone in pediatric patients.
Hemodialysis: tolcapone is highly protein bound, therefore no significant removal of the drug is expected.
Tolcapone may be taken with or without food.
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- Drug class: dopaminergic antiparkinsonism agents
Other brands: Tasmar