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Tolcapone Dosage

Applies to the following strength(s): 100 mg ; 200 mg

The information at is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for Parkinson's Disease

100 mg orally three times daily, always taken together with the first dose of the day of levodopa/carbidopa.

Renal Dose Adjustments

CrCl less than 25 mL/min: not recommended

Liver Dose Adjustments

Clearance and volume of distribution of unbound tolcapone was reduced by almost 50% in patients with moderate cirrhotic liver disease (Child-Pugh Class B). This change may increase the average serum concentration of unbound drug by twofold.

Dose Adjustments

The dose may be increased to 200 mg three times daily only if the anticipated incremental benefit is justified. If the patient fails to show substantial clinical benefit within 3 weeks of start of tolcapone, tolcapone should be discontinued.

If the daily of dose of levodopa exceed 600 mg or if patient had moderate or severe dyskinesia, a decrease in dose may be warranted.


Safety and effectiveness have not been established in pediatric patients (less than 18 years of age). There is no identified potential use of tolcapone in pediatric patients.


Hemodialysis: tolcapone is highly protein bound, therefore no significant removal of the drug is expected.

Other Comments

Tolcapone may be taken with or without food.