Steglujan Dosage

Prior to Initiation of STEGLUJAN

• Assess renal function prior to initiation of STEGLUJAN and as clinically indicated [see Warnings and Precautions (5.4)].
• ​Assess volume status. In patients with volume depletion, correct this condition before initiating STEGLUJAN [see Warnings and Precautions (5.5), Use in Specific Populations (8.5, 8.6)].

Recommended Dosage

• The recommended starting dose of STEGLUJAN is 5 mg ertugliflozin/100 mg sitagliptin once daily, taken in the morning, with or without food.
• For patients treated with ertugliflozin who are being switched to STEGLUJAN, the dose of ertugliflozin can be maintained.
• For additional glycemic control, the dose may be increased to 15 mg ertugliflozin/100 mg sitagliptin once daily in patients tolerating STEGLUJAN.
• Use is not recommended in patients with an eGFR less than 45 mL/min/1.73 m2.
• Use of STEGLUJAN is contraindicated in patients with severe renal impairment (<30 mL/min/1.73 m2), end-stage renal disease (ESRD) or on dialysis [see Contraindications (4)].

​2.3 Temporary Interruption for Surgery

​Withhold STEGLUJAN for at least 4 days, if possible, prior to major surgery or procedures associated with prolonged fasting. Resume STEGLUJAN when the patient is clinically stable and has resumed oral intake [see Warnings and Precautions (5.1) and Clinical Pharmacology (12.2)].