Medically reviewed by Drugs.com. Last updated on April 30, 2021.
Generic name: salmeterol xinafoate
Dosage form: Inhalation Aerosol
SEREVENT Inhalation Aerosol should be administered by the orally inhaled route only (see PATIENT’S INSTRUCTIONS FOR USE). It is recommended to “test spray” SEREVENT Inhalation Aerosol into the air 4 times before using for the first time and in cases where the aerosol has not been used for a prolonged period of time (i.e., more than 4 weeks).
For maintenance of bronchodilatation and prevention of symptoms of asthma, including the symptoms of nocturnal asthma, the usual dosage for patients 12 years of age and older is 2 inhalations (42 mcg) twice daily (morning and evening, approximately 12 hours apart). Adverse effects are more likely to occur with higher doses of salmeterol, and more frequent administration or administration of a larger number of inhalations is not recommended.
To gain full therapeutic benefit, SEREVENT Inhalation Aerosol should be administered twice daily (morning and evening) in the treatment of reversible airway obstruction.
If a previously effective dosage regimen fails to provide the usual response, medical advice should be sought immediately as this is often a sign of destabilization of asthma. Under these circumstances, the therapeutic regimen should be re-evaluated and additional therapeutic options, such as inhaled or systemic corticosteroids, should be considered. If symptoms arise in the period between doses, an inhaled, short-acting beta2-agonist should be taken for immediate relief.
Chronic Obstructive Pulmonary Disease
For maintenance treatment of bronchospasm associated with COPD (including chronic bronchitis and emphysema), the usual dosage for adults is 2 inhalations (42 mcg) twice daily (morning and evening, approximately 12 hours apart).
Prevention of Exercise-Induced Bronchospasm
Two inhalations at least 30 to 60 minutes before exercise have been shown to protect against EIB in many patients for up to 12 hours. Additional doses of SEREVENT Inhalation Aerosol should not be used for 12 hours after the administration of this drug. Patients who are receiving SEREVENT Inhalation Aerosol twice daily (morning and evening) shouldnotuse additional SEREVENT Inhalation Aerosol for prevention of EIB. If this dose is not effective, other appropriate therapy for EIB should be considered.
In studies where geriatric patients (65 years of age or older, see PRECAUTIONS) have been treated with SEREVENT Inhalation Aerosol, efficacy and safety of 42 mcg given twice daily (morning and evening) did not differ from that in younger patients. Consequently, no dosage adjustment is recommended.
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