Pergolide Dosage

Applies to the following strengths: 0.25 mg; 0.05 mg; 1 mg

Usual Adult Dose for Parkinson's Disease

Pergolide was voluntary withdrawn from the US market by the manufacturer in March, 2007 due to increased reports of serious heart valves damage. The following dosage information applies to when the drug was available in the U.S.

Initial: 0.05 mg orally once a day for the first 2 days.

Maintenance: Gradually increase in increments of 0.1 to 0.15 mg every third day over the next 12 days. Then increase by 0.25 mg every third day until an optimal dosage is achieved. The daily dose is usually divided into 3 to 4 doses/day. The average dosage is 3 mg/day. Doses above 5 mg/day have not been studied.

Usual Adult Dose for Hyperprolactinemia

Usual Pediatric Dose for Tourette's Syndrome

Pergolide was voluntary withdrawn from the US market by the manufacturer in March, 2007 due to increased reports of serious heart valves damage. The following dosage information applies to when the drug was available in the U.S.

Study (n equals 18), 1 month duration:
8 to 17 years: initially 25 mcg/day, 2 to 3 days later the dose was titrated to 50 mcg three times daily, then titrated upwards every 3 days by 50 mcg per dose to a final dose of 150 mcg three times daily. The maximum dose used in 4 patients was 300 mcg three times daily.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Other Comments

The addition of pergolide to the therapy of patients with Parkinson's Disease allows for a reduction in levodopa/carbidopa dosage in most patients and a decrease in "off" time. The long duration of action of pergolide decreases wearing-off or end-of-dose effects of levodopa. The dosage of levodopa/carbidopa may be cautiously reduced during pergolide therapy. Limited data suggests the clinical benefit of pergolide may peak between 6-12 months, and decrease thereafter. Some patients have shown clinical benefit from pergolide for up to 7 years.