Skip to main content

Nitroprusside Dosage

Medically reviewed by Drugs.com. Last updated on Aug 16, 2023.

Applies to the following strengths: 50 mg; 25 mg/mL; 50 mg/100 mL-NaCl 0.9%; 10 mg/50 mL-NaCl 0.9%; 20 mg/100 mL-NaCl 0.9%

Usual Adult Dose for Congestive Heart Failure

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Adult Dose for Hypertensive Emergency

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Adult Dose for Induced Hypotension

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Adult Dose for Hypertensive Urgency

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Pediatric Dose for Congestive Heart Failure

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Pediatric Dose for Hypertensive Emergency

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Pediatric Dose for Induced Hypotension

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Usual Pediatric Dose for Hypertensive Urgency

0.3 mcg/kg/min infusion; evaluate blood pressure for at least 5 minutes before titrating to a higher or lower dose to achieve desired blood pressure; upward titration may be implemented until the desired effect is achieved, systemic blood pressure cannot be further reduced without compromising vital organ perfusion, or the maximum recommended infusion rate has been reached, whichever occurs first.

Maximum dose: 10 mcg/kg/min

Comments:


Uses:

Renal Dose Adjustments

eGFR 30 mL/min/1.73 m2 or greater: Data not available
eGFR less than 30 mL/min/1.73 m2: Limit mean infusion rate to less than 3 mcg/kg/min
Anuric patients: Limit mean infusion rate to 1 mcg/kg/min

Liver Dose Adjustments

Use with caution.

Precautions

US BOXED WARNINGS:


CONTRAINDICATIONS:

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements: The manufacturer product information should be consulted.

Reconstitution/preparation techniques: The manufacturer product information should be consulted.

IV compatibility: Do not administer other drugs in the same solution with this drug.

Monitoring:

Patient advice: Inform female patients of reproductive potential that this drug may cause fetal harm and to inform their prescriber of a known or suspected pregnancy.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.