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Minocycline Topical Dosage

Medically reviewed by Last updated on Feb 6, 2023.

Applies to the following strengths: 1 mg; 4%; 1.5%

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Periodontitis

Adult periodontitis:
1 mg applied subgingivally by an oral health care professional into the base of the affected periodontal pocket. The quantity of 1 mg unit dose packets required for treatment varies with the depth, severity, and number of lesions. During clinical trials, up to 121 unit dose containers of minocycline topical were applied to a single patient during a single treatment session. Additionally, patients were treated in up to 3 sessions occurring at 3 month intervals.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available


Data not available

Other Comments

Minocycline topical microspheres are approved as an adjunct to scaling and root planing procedures for reduction of pocket depth in patients with adult periodontitis.

Minocycline topical should be dispensed to and administered by an oral health care professional.

The use of minocycline topical microspheres in an acutely abscessed periodontal pocket has not been studied and is not recommended.

Use minocycline topical microspheres with caution in patients predisposed to oral candidiasis infections.

Because of the potential for tooth-staining, the use of minocycline topical microspheres in pediatric patients is not recommended.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.