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Lutetium Lu 177 Vipivotide Tetraxetan Dosage

Applies to the following strengths: 1000 MBq/mL

Usual Adult Dose for Prostate Cancer

7.4 GBq (200 mCi) IV every 6 weeks
Duration of therapy: Up to 6 doses, OR until disease progression or unacceptable toxicity

Comments:


Use: For the treatment of patients with PSMA-positive mCRPC who have been treated with androgen receptor pathway inhibition and taxane-based chemotherapy

Renal Dose Adjustments

Mild (baseline CrCl 60 to 89 mL/min [by Cockcroft-Gault]) or moderate (CrCl 30 to 59 mL/min) renal dysfunction: No adjustment recommended.
Severe (CrCl 15 to 29 mL/min) renal dysfunction or ESRD: Data not available

If renal toxicity develops during therapy:


Comments:

Liver Dose Adjustments

Data not available

If AST or ALT elevation during therapy:

Dose Adjustments

Management of adverse reactions may require temporary dose interruption (extending the dosing interval from every 6 weeks up to every 10 weeks), dose reduction, or permanent discontinuation of therapy.


For Adverse Reactions:
Dry mouth:

Electrolyte or metabolic abnormalities:

Fatigue:

Gastrointestinal toxicity:

Myelosuppression (anemia, thrombocytopenia, leukopenia, or neutropenia):

Other nonhematologic toxicity:

Precautions

CONTRAINDICATIONS: None

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


Storage requirements:

Reconstitution/preparation techniques:

General:

Monitoring:

Patient advice:

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.