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Insulin Glargine / Lixisenatide Dosage

Medically reviewed by Last updated on May 11, 2023.

Applies to the following strengths: 100 units-33 mcg/mL

Usual Adult Dose for Diabetes Type 2

Insulin glargine 100 units/lixisenatide 33 mcg per mL (100/33); dosage is expressed in insulin glargine units

DISCONTINUE basal insulin or glucagon-like peptide-1 (GLP-1) receptor agonist prior to initiating this drug:

For Patients Receiving 30 to 60 units of Basal Insulin With or Without a GLP-1 Receptor Agonist:

TITRATE dose up or down in increments of 2 to 4 units/week based on metabolic needs, blood glucose monitoring results, and glycemic goal until desired fasting plasma glucose is achieved


Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.

Renal Dose Adjustments

Mild to severe renal impairment: Use with caution; frequent glucose monitoring and dose adjustment may be necessary
ESRD (CrCl less than 15 mL/min): Not recommended

Liver Dose Adjustments

Use with caution; frequent glucose monitoring and dose adjustment may be necessary

Dose Adjustments


Dosed as insulin glargine units; product labeling provides a dose chart with lixisenatide mcg dose corresponding to insulin glargine units.

Concomitant Use of an Insulin Secretagogue (e.g., Sulfonylurea) or Insulin:

Additional titration of dose may be needed with changes in physical activity, meal patterns (macronutrient content or timing of meals), during acute illness, or when used with other medications.



Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Data not available

Other Comments

Administration advice:

Missed doses:

Storage requirements:

Reconstitution/preparation techniques:

Compatibility: Do not mix with any other products; do not add to infusion fluids



Patient advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.