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Hydroflumethiazide / Reserpine Dosage

Applies to the following strengths: 50 mg-0.125 mg; 25 mg-0.125 mg

Usual Adult Dose for Hypertension

Initial dose: 1 to 2 tablets (hydroflumethiazide/reserpine 25 mg-0.125 mg) orally once a day or 1 tablet (hydroflumethiazide/reserpine 50 mg-0.125 mg) orally once a day.
Should conform to the dosages of the individual components established during titration.

Maintenance dose: May increase to 1 tablet (hydroflumethiazide/reserpine 50 mg-0.125 mg) orally twice a day if necessary.

Renal Dose Adjustments

Reserpine-hydroflumethiazide is not recommended in patients with severe renal impairment because the half-life of reserpine is significantly prolonged in patients with renal insufficiency and hydroflumethiazide is not expected to be filtered into the renal tubule (its site of action) when the glomerular filtration rate is less than 25 mL/min.

Liver Dose Adjustments

Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.

Dose Adjustments

The dose may be increased as needed every 1 to 2 weeks.


Doses higher than 0.25 mg daily of reserpine should be used cautiously, because occurrence of serious mental depression and other side effects may increase considerably.


Reserpine is not dialyzable.

Other Comments

Daily doses of hydroflumethiazide greater than 200 mg are not recommended.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.