Famvir Dosage

Generic name: FAMCICLOVIR 125mg
Dosage form: tablet, film coated
Drug class: Purine nucleosides

Medically reviewed by Drugs.com. Last updated on Sep 6, 2024.

FAMVIR may be taken with or without food.

2.1 Dosing Recommendation in Immunocompetent Adult Patients

Herpes labialis (cold sores): The recommended dosage of FAMVIR for the treatment of recurrent herpes labialis is 1500 mg as a single dose. Therapy should be initiated at the first sign or symptom of herpes labialis (e.g., tingling, itching, burning, pain, or lesion).

Genital herpes:

Recurrent episodes: The recommended dosage of FAMVIR for the treatment of recurrent episodes of genital herpes is 1000 mg twice daily for 1 day. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion).

Suppressive therapy: The recommended dosage of FAMVIR for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily.

Herpes zoster (shingles): The recommended dosage of FAMVIR for the treatment of herpes zoster is 500 mg every 8 hours for 7 days. Therapy should be initiated as soon as herpes zoster is diagnosed.

2.2 Dosing Recommendation in HIV-Infected Adult Patients

Recurrent orolabial or genital herpes: The recommended dosage of FAMVIR for the treatment of recurrent orolabial or genital herpes in HIV-infected patients is 500 mg twice daily for 7 days. Therapy should be initiated at the first sign or symptom of a recurrent episode (e.g., tingling, itching, burning, pain, or lesion).

2.3 Dosing Recommendation in Patients with Renal Impairment

Dosage recommendations for adult patients with renal impairment are provided in Table 1.

Table 1: Dosage Recommendations for Adult Patients with Renal Impairment
Indication and Normal Dosage Regimen	Creatinine Clearance (mL/min)	Adjusted Dosage Regimen Dose (mg)	Dosing Interval
Single-Day Dosing Regimens
Recurrent Genital Herpes 1000 mg every 12 hours for 1 day	≥ 60	1000	every 12 hours for 1 day
	40-59	500	every 12 hours for 1 day
	20-39	500	single dose
	< 20	250	single dose
	HD*	250	single dose following dialysis
Recurrent Herpes Labialis 1500 mg single dose	≥ 60	1500	single dose
	40-59	750	single dose
	20-39	500	single dose
	< 20	250	single dose
	HD*	250	single dose following dialysis
Multiple-Day Dosing Regimens
Herpes Zoster 500 mg every 8 hours	≥ 60	500	every 8 hours
	40-59	500	every 12 hours
	20-39	500	every 24 hours
	< 20	250	every 24 hours
	HD*	250	following each dialysis
Suppression of Recurrent Genital Herpes 250 mg every 12 hours	≥ 40	250	every 12 hours
	20-39	125	every 12 hours
	< 20	125	every 24 hours
	HD*	125	following each dialysis
Recurrent Orolabial or Genital Herpes in HIV-Infected Patients 500 mg every 12 hours	≥ 40	500	every 12 hours
	20-39	500	every 24 hours
	< 20	250	every 24 hours
	HD*	250	following each dialysis