Etopophos Dosage
Generic name: etoposide phosphate 100mg
Dosage form: injection, powder, lyophilized, for solution
Drug class: Mitotic inhibitors
Medically reviewed by Drugs.com. Last updated on Dec 31, 2024.
Refractory Testicular Tumors
The recommended dose of ETOPOPHOS is:
- 50 to 100 mg/m2 per day administered intravenously over 5 minutes to 3.5 hours on days 1 through 5 of each 21-day (or 28-day cycle), or
- 100 mg/m2 administered intravenously over 5 minutes to 3.5 hours on days 1, 3, and 5 of each 21-day (or 28-day cycle).
Small Cell Lung Cancer
The recommended dose of ETOPOPHOS is:
• 35 mg/m2 per day administered intravenously over 5 minutes to 3.5 hours for 4 days, or
• 50 mg/m2 per day administered intravenously over 5 minutes to 3.5 hours for 5 days.
Dosage Modification
In patients with a creatinine clearance (CLcr) 15-50 mL/min, administer 75% of the recommended dose.
Data are not available in patients with CLcr less than 15 mL/min. Consider further dose reduction in these patients.
Preparation and Administration
Preparation
- Reconstitute with Sterile Water for Injection, USP; 5% Dextrose Injection, USP; 0.9% Sodium Chloride Injection, USP; Bacteriostatic Water for Injection with Benzyl Alcohol; or Bacteriostatic Sodium Chloride for Injection with Benzyl Alcohol, using the quantity of diluent shown below:
Vial Strength | Volume of Diluent | Final Concentration |
100 mg | 5 mL | 20 mg/mL |
10 mL | 10 mg/mL |
- Following reconstitution, ETOPOPHOS can be further diluted to concentrations as low as 0.1 mg/mL with either 5% Dextrose Injection, USP, or 0.9% Sodium Chloride Injection, USP.
- Inspect parenteral drug products visually for particulate matter and discoloration prior to administration whenever solution and container permit.
Storage
After reconstitution, store under the following conditions:
- Refrigerated 2° to 8°C (36° to 46°F) for 7 days;
- Room temperature at 20° to 25°C (68° to 77°F) for 24 hours following reconstitution with Sterile Water for Injection, USP, 5% Dextrose Injection, USP, or 0.9% Sodium Chloride Injection, USP;
- Room temperature 20° to 25°C (68° to 77°F) for 48 hours following reconstitution with Bacteriostatic Water for Injection with benzyl alcohol or Bacteriostatic Sodium Chloride for Injection with benzyl alcohol.
Reconstituted ETOPOPHOS solutions further diluted as directed can be stored under refrigeration 2° to 8°C (36° to 46°F) or at room temperature 20° to 25°C (68° to 77°F) for 24 hours.
Administration
DO NOT GIVE ETOPOPHOS BY BOLUS INTRAVENOUS INJECTION. ETOPOPHOS solutions may be administered at infusion rates up to 3.5 hours. Extravasation of ETOPOPHOS may result in swelling, pain, cellulitis, and necrosis including skin necrosis.
ETOPOPHOS is a cytotoxic drug. Follow applicable special handling and disposal procedures.1 To minimize the risk of dermal exposure, use of gloves is recommended. If dermal contact occurs, immediately and thoroughly wash areas of skin contact with soap and water and flush mucosa with water.
Frequently asked questions
- How long does chemo take? Sessions, cycles, and recovery time?
- Radiation vs. Chemo: Which cancer treatment is right for you?
- How soon will my hair grow back after chemotherapy?
- Will I lose my hair during chemotherapy treatment?
- What is EPOCH/R-EPOCH chemo regimen and how is it used?
More about Etopophos (etoposide)
- Check interactions
- Compare alternatives
- Side effects
- During pregnancy
- Drug class: mitotic inhibitors
- Breastfeeding
- En español
Patient resources
Other brands
Professional resources
Other brands
Related treatment guides
See also:
Opdivo
Opdivo is used to treat many cancers, such as melanoma, non-small cell lung cancer, malignant ...
Avastin
Avastin is used to brain tumors and cancers of the kidney, colon, rectum, or lung. Learn about side ...
Keytruda
Keytruda is used to treat multiple types of cancer such as melanoma, non-small cell lung cancer ...
Durvalumab
Durvalumab (Imfinzi) is an immunotherapy used to treat lung cancer (NSCLC, SCLC) and other cancers ...
Vincristine
Vincristine systemic is used for acute lymphocytic leukemia, acute myeloid leukemia, anaplastic ...
Gemcitabine
Gemcitabine systemic is used for breast cancer, breast cancer, metastatic, nasopharyngeal ...
Nivolumab
Nivolumab (brand name Opdivo) is an immunotherapy treatment that treats many cancers, such as ...
Doxorubicin
Doxorubicin systemic is used for acute lymphoblastic leukemia, acute myeloblastic leukemia, bladder ...
Paclitaxel
Paclitaxel systemic is used for breast cancer, breast cancer, adjuvant, breast cancer, metastatic ...
Cyclophosphamide
Cyclophosphamide systemic is used for acute lymphocytic leukemia, acute nonlymphocytic leukemia ...
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.