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Estradiol / Levonorgestrel Dosage

Medically reviewed by Drugs.com. Last updated on Mar 20, 2023.

Applies to the following strengths: 0.045 mg-0.015 mg/24 hr

Usual Adult Dose for Postmenopausal Symptoms

Apply one patch (estradiol 0.045 mg per day/levonorgestrel 0.015 mg per day) to skin on lower abdomen or upper quadrant of buttock once a week


Comments:

Uses:

Usual Adult Dose for Prevention of Osteoporosis

Apply one patch (estradiol 0.045 mg per day/levonorgestrel 0.015 mg per day) to skin on lower abdomen or upper quadrant of buttock once a week


Comments:

Uses:

Renal Dose Adjustments

Use caution; no dose adjustments recommended

Liver Dose Adjustments

Known liver impairment or disease: Contraindicated

Precautions

US BOXED WARNINGS: CARDIOVASCULAR DISORDERS, BREAST CANCER, ENDOMETRIAL CANCER, AND PROBABLE DEMENTIA

Recommendations:

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Hemodialysis: Use with caution; patients with ESRD receiving maintenance hemodialysis have higher total serum estradiol levels which may be excessive
Peritoneal dialysis: Data not available

Other Comments

Administration advice:


Storage requirements:

General:

Monitoring:

Patient advice:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.