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Duraclon Injection Dosage

Generic name: CLONIDINE HYDROCHLORIDE 0.1mg in 1mL
Dosage form: injection, solution

Medically reviewed on October 11, 2016.

The recommended starting dose of Duraclon for continuous epidural infusion is 30 mcg/hr. Although dosage may be titrated up or down depending on pain relief and occurrence of adverse events, experience with dosage rates above 40 mcg/hr is limited.

Familiarization with the continuous epidural infusion device is essential. Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response.

The 500 mcg/mL (0.5 mg/mL) strength product must be diluted prior to use in 0.9% Sodium Chloride for Injection, U.S.P., to a final concentration of 100 mcg/mL:

Volume of


500 mcg/mL

Volume of 0.9%

Sodium Chloride

for Injection, U.S.P.

Resulting Final Duraclon


(100 mcg/mL)

1 mL

4 mL

500 mcg/5 mL

2 mL

8 mL

1000 mcg/10 mL

3 mL

12 mL

1500 mcg/15 mL

4 mL

16 mL

2000 mcg/20 mL

5 mL

20 mL

2500 mcg/25 mL

6 mL

24 mL

3000 mcg/30 mL

7 mL

28 mL

3500 mcg/35 mL

8 mL

32 mL

4000 mcg/40 mL

9 mL

36 mL

4500 mcg/45 mL

10 mL

40 mL

5000 mcg/50 mL

Renal Impairment

Dosage should be adjusted according to the degree of renal impairment, and patients should be carefully monitored. Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis.

Duraclon must not be used with a preservative.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.