Applies to the following strengths: 4 mg; 8 mg; 1 mg; 2 mg
The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Hypertension
Initial dose: 1 mg orally once a day
Maintenance dose: 1 to 16 mg orally once a day
Comments: Dosage may be doubled up to 16 mg once a day as needed to achieve desired blood pressure reduction.
Usual Adult Dose for Benign Prostatic Hyperplasia
-Immediate release: 1 mg orally once a day in the morning or evening
-Extended release: 4 mg orally once a day with breakfast
-Immediate release: 1 to 8 mg orally once a day in the morning or evening
-Extended release: 4 to 8 mg orally once a day with breakfast
Maximum dose: 8 mg orally once a day
Comments: Depending on the patient's urodynamics, symptomatic response, and tolerability, the dose may be doubled after 1 to 2 weeks (immediate release) or 3 to 4 weeks (extended release) at the previous dose.
Use: Treatment of signs and symptoms of benign prostatic hyperplasia (BPH).
Renal Dose Adjustments
Data not available
Liver Dose Adjustments
Mild to moderate liver dysfunction (Child-Pugh A or B): Use with caution
Severe liver dysfunction (Child-Pugh C): Not recommended
Conversion from immediate release to extended release:
-Skip the final evening dose of the immediate release formulation and initiate the extended release formulation at the lowest dose (4 mg once a day).
Coadministration with phosphodiesterase-5 (PDE-5) inhibitors:
-Extended release: Initiate treatment at the lowest dose.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Data not available
-If this drug is discontinued for several days, therapy should be restarted using the initial dosing regimen.
-Extended release: Tablets should be swallowed whole; do not chew, crush, cut, or divide tablets.
-Cardiovascular: Blood pressure (for at least 6 hours after the initial dose and each dose increase and routinely thereafter)
-Advise patients how to avoid symptoms of postural hypotension and what to do if they occur. Also, encourage patients to avoid situations where injury could result if these symptoms occur.
-Inform male patients about the seriousness of priapism and instruct them to seek immediate medical attention if it occurs.
-Advise patients to report current or previous use of this drug to their ophthalmologist.
-Extended release formulations may contain a nonabsorbable coating designed to control drug release over time. Advise patients not to be concerned if they notice tablet remains in their stools.
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- Drug class: antiadrenergic agents, peripherally acting