Skip to Content

Clobazam Dosage

Applies to the following strength(s): 5 mg ; 10 mg ; 20 mg ; 2.5 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Geriatric Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Lennox-Gastaut Syndrome

Initial daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight 30 kg or more: 10 mg orally per day
Starting day 7 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight 30 kg or more: 20 mg orally per day
Starting day 14 daily dose:
-Body weight 30 kg or less: 20 mg orally per day
-Body weight 30 kg or more: 40 mg orally per day

Comments:
-A daily dose greater than 5 mg should be administered in divided doses twice a day.
-Dose should be escalated no more rapidly than weekly.
-Dose should be withdrawn gradually by tapering the total daily dose by 5 to 10 mg/day on a weekly basis until discontinued.

Use: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS)

Usual Geriatric Dose for Lennox-Gastaut Syndrome

Initial dose: 5 mg orally per day
Maintenance dose: Dose should be initially titrated to 10 to 20 mg orally per day.
Maximum dose: After the initial titration to 10 to 20 mg orally per day, the patient may be further titrated to the maximum dose (20 to 40 mg orally per day based on weight) may be started on day 21.

Comments:
-Dose should be escalated slowly.
-Titration should be done according to weight, but to half the dose presented for adult patients, as tolerated.

Use: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS)

Usual Pediatric Dose for Lennox-Gastaut Syndrome

2 years or older:
Initial daily dose:
-Body weight 30 kg or less: 5 mg orally per day
-Body weight 30 kg or more: 10 mg orally per day
Starting day 7 total daily dose:
-Body weight 30 kg or less: 10 mg orally per day
-Body weight 30 kg or more: 20 mg orally per day
Starting day 14 daily dose:
-Body weight 30 kg or less: 20 mg orally per day
-Body weight 30 kg or more: 40 mg orally per day

Comments:
-A daily dose greater than 5 mg should be administered in divided doses twice a day.
-Dose should be escalated no more rapidly than weekly.
-Dose should be withdrawn gradually by tapering the total daily dose by 5 to 10 mg/day on a weekly basis until discontinued.

Use: Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS)

Renal Dose Adjustments

Mild to moderate renal dysfunction: No adjustment recommended
Severe renal dysfunction or ESRD: Data not available

Liver Dose Adjustments

Mild to moderate hepatic impairment (Child-Pugh score 5 to 9):
Initial dose: 5 mg orally per day
Maintenance dose: Dose should be initially titrated to 10 to 20 mg orally per day.
Maximum dose: After the initial titration to 10 to 20 mg orally per day, the patient may be further titrated to the maximum dose (20 to 40 mg orally per day based on weight) may be started on day 21. Dose should be escalated slowly and titration should be done according to weight, but to half the dose presented for adult patients, as tolerated.

Severe hepatic impairment: Data not available

Dose Adjustments

CYP450 2C19 poor metabolizers:
Initial dose: 5 mg orally per day
Maintenance dose: Dose should be initially titrated to 10 to 20 mg orally per day.
Maximum dose: After the initial titration to 10 to 20 mg orally per day, the patient may be further titrated to the maximum dose (20 to 40 mg orally per day based on weight) may be started on day 21.

Comments:
-Dose should be escalated slowly.
-Titration should be done according to weight, but to half the dose presented for adult patients, as tolerated.

Precautions

Safety and efficacy have not been established in patients younger than 2 years.

Consult WARNINGS section for additional precautions.

US Controlled Substance: Schedule IV

Dialysis

Data not available

Other Comments

Administration advice:
-Tablets can be administered whole, broken in half along the score, or crushed and mixed in applesauce.
-This drug can be administered without regard to meals.
-Oral suspension: The manufacturer product information should be consulted.

Monitoring:
-Nervous system: Anterograde amnesia, drowsiness, dizziness
-Other: Withdrawal side effects (e.g., rebound insomnia, tolerance, dependence)
-Psychiatric: Anxiety, emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood or behavior.

Patient advice:
-This drug may cause drowsiness and dizziness and reduce alertness. Do not drive a car or operate dangerous machinery until you know how this drug affects you.
-Do not drink alcohol or take other drugs that may cause sleepiness or dizziness while taking this drug until you talk to your healthcare provider.

Hide