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Chloramphenicol Dosage

Applies to the following strengths: 250 mg; 1000 mg; palmitate

Usual Adult Dose for Bacteremia

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Meningitis

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Rickettsial Infection

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Bacterial Infection

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Cystic Fibrosis

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Typhoid Fever

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Gram Negative Infection

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Psittacosis

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Ornithosis

12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

Infectious Diseases Society of America (IDSA) Recommendations for Bacterial Meningitis: 1 to 1.5 g IV every 6 hours

Comments:

Usual Adult Dose for Inhalation Bacillus anthracis

US CDC Recommendations: 1 g IV every 6 to 8 hours
Duration of Therapy: At least 2 to 3 weeks or until patient is clinically stable (whichever is longer)


Comments:

Usual Adult Dose for Cutaneous Bacillus anthracis

US CDC Recommendations: 1 g IV every 6 to 8 hours
Duration of Therapy: At least 2 to 3 weeks or until patient is clinically stable (whichever is longer)


Comments:

Usual Adult Dose for Plague

US CDC Recommendations: 25 mg/kg IV every 6 hours
Duration of therapy: 10 to 14 days (or until 2 days after fever subsides)

Comments:

Usual Adult Dose for Tularemia

Working Group on Civilian Biodefense Recommendations: 15 mg/kg IV 4 times a day
Duration of therapy: 14 to 21 days

Comments:

Usual Pediatric Dose for Bacteremia

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Meningitis

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Rickettsial Infection

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Bacterial Infection

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Cystic Fibrosis

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Typhoid Fever

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Gram Negative Infection

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Psittacosis

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Ornithosis

Premature neonates and full-term neonates under 2 weeks of age: 6.25 mg/kg IV every 6 hours
Full-term neonates at least 2 weeks of age: Up to 12.5 mg/kg IV every 6 hours
Children: 12.5 to 25 mg/kg IV every 6 hours

Comments:


Uses:

American Academy of Pediatrics (AAP) Recommendations:
1 month or older: 12.5 to 25 mg/kg IV 4 times a day

IDSA Recommendations for Bacterial Meningitis:
Neonates 0 to 7 days: 25 mg/kg IV every 24 hours
Neonates 8 to 28 days: 50 mg/kg/day IV in divided doses every 12 to 24 hours
Infants and children: 18.75 to 25 mg/kg IV every 6 hours

Comments:

Usual Pediatric Dose for Inhalation Bacillus anthracis

AAP Recommendations:
Neonates up to 4 weeks of age:


Children 1 month or older: 25 mg/kg IV every 6 hours

Duration of Therapy: At least 2 to 3 weeks or until patient is clinically stable (whichever is longer)

Comments:

Usual Pediatric Dose for Cutaneous Bacillus anthracis

AAP Recommendations:
Neonates up to 4 weeks of age:


Children 1 month or older: 25 mg/kg IV every 6 hours

Duration of Therapy: At least 2 to 3 weeks or until patient is clinically stable (whichever is longer)

Comments:

Usual Pediatric Dose for Plague

US CDC Recommendations:
Children over 2 years: 25 mg/kg IV every 6 hours
Maximum dose: 4 g/day
Duration of therapy: 10 to 14 days (or until 2 days after fever subsides)

Comments:

Usual Pediatric Dose for Tularemia

Working Group on Civilian Biodefense Recommendations:
Children: 15 mg/kg IV 4 times a day
Duration of therapy: 14 to 21 days

Comments:

Renal Dose Adjustments

Renal dysfunction: Dose adjustments may be required; however, no specific guidelines have been suggested.

Comments:

Liver Dose Adjustments

Liver dysfunction: Dose adjustments may be required; however, no specific guidelines have been suggested.

Comments:

Dose Adjustments

Adults with impaired metabolic processes: Dose should be adjusted accordingly; blood level should be determined at appropriate intervals.

Pediatric patients with immature metabolic processes: In young infants and other pediatric patients with suspected immature metabolic functions, a total of 25 mg/kg/day generally produces therapeutic drug levels in the blood; the blood level of this drug should be carefully monitored in these patients.

Precautions

US BOXED WARNING:


CONTRAINDICATIONS:

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:


General:

Monitoring:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.