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Axitinib Dosage

Medically reviewed by Drugs.com. Last updated on Oct 7, 2022.

Applies to the following strengths: 1 mg; 5 mg

Usual Adult Dose for Renal Cell Carcinoma

Initial dose: 5 mg orally twice a day
Maintenance dose: Increase or decrease dose based on individual safety and tolerability
Dose range: 2 to 10 mg twice a day

Comments: Doses should be taken approximately 12 hours apart.

Use: For the treatment of advanced renal cell carcinoma after the failure of 1 prior systemic therapy.

Renal Dose Adjustments

Mild to severe renal impairment (CrCl 15 mL/min to less than 89 mL/min): No adjustment to starting dose recommended
Severe renal impairment (CrCl less than 15 mL/min): Use with caution

Liver Dose Adjustments

Mild hepatic impairment (Child-Pugh class A): No adjustment to starting dose recommended
Moderate hepatic impairment (Child-Pugh class B): Decrease the starting dose by one-half
Severe hepatic impairment (Child-Pugh class C): Not recommended as not studied in these patients

Dose Adjustments

Dose increases or dose reductions should be made based on individual patient safety and tolerability.

Dose Increases:


Dose Reductions:

Discontinuation or Temporary Interruption:

Strong CYP450 3A4/5 Inhibitors and Inducers:
Recommendations:

Precautions

CONTRAINDICATIONS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available.

Other Comments

Administration advice:


General:
Therapy should be initiated by a physician experienced in the administration of anti-cancer agents.

Monitoring:

Patient Advice:

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.