Antara Dosage
Generic name: FENOFIBRATE 30mg
Dosage form: capsule
Drug class: Fibric acid derivatives
Medically reviewed by Drugs.com. Last updated on Aug 20, 2024.
Prior to Initiation of Antara
- Assess lipid levels before initiating therapy. Identify other causes (e.g., diabetes mellitus, hypothyroidism, or medications) of high triglyceride levels and manage as appropriate.
- Patients should be placed on an appropriate lipid-lowering diet before receiving Antara and should continue this diet during treatment with Antara.
- In patients with diabetes and fasting chylomicronemia, improve glycemic control prior to considering starting Antara.
Recommended Dosage and Administration
• Severe hypertriglyceridemia:
○ The recommended dosage of Antara is 30 mg or 90 mg orally once daily.
○ Dosage should be individualized according to patient response, and should be adjusted if necessary following repeat lipid determinations at 4 to 8 week intervals.
• Primary hyperlipidemia:
○ The recommended dosage of Antara is 90 mg orally once daily.
• Administer Antara as a single dose at any time of day, with or without food.
• Advise patients to swallow Antara capsules whole. Do not crush, break, dissolve, or chew capsules.
• Assess TG when clinically appropriate, as early as 4 to 8 weeks after initiating Antara. Discontinue Antara in patients who do not have an adequate response after two months of treatment.
• If a dose is missed, advise patients not to take an extra dose. Resume treatment with the next dose.
• Advise patients to take Antara at least 1 hour before or 4 hours to 6 hours after a bile acid binding resin to avoid impeding its absorption.
Recommended Dosage in Patients with Renal Impairment
- Assess renal function prior to initiation of Antara and periodically thereafter.
- Treatment with Antara should be initiated at a dosage of 30 mg orally once daily in patients with mild to moderately impaired renal function (eGFR 30 to <60 mL/min/1.73m2), and increased only after evaluation of the effects on renal function and TG levels at this dose.
- Antara is contraindicated in patients with severe renal impairment (eGFR <30 mL/min/ 1.73m2), including those with end-stage renal disease (ESRD) and those receiving dialysis
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