Skip to main content

Tirofiban Disease Interactions

There are 2 disease interactions with tirofiban.

Major

GpIIb/IIIa platelet inhibitors (applies to tirofiban) bleeding risks

Major Potential Hazard, High plausibility. Applicable conditions: Thrombocytopenia, Thrombocytopathy, Coagulation Defect, Cerebral Vascular Disorder, Hypertension, Brain/Intracranial Tumor

The use of gp11b/111a platelet inhibitors is contraindicated in patients with active internal bleeding, recent significant gastrointestinal or genitourinary bleeding (within 6 weeks), recent trauma or major surgery (within 6 weeks), history of bleeding diathesis, recent stroke (within 4 weeks), history of hemorrhage stroke or residual neurologic deficit, intracranial defect (aneurysm, arteriovenous malformation, neoplasm), uncontrolled hypertension (SBP > 180; DBP > 110), or thrombocytopenia (<100,000/mm3). Thrombocytopenia, serious GI/GU bleeding, hemorrhagic retinopathy, and bleeding at the arterial access have been reported during gp11b/111a platelet inhibitor therapy. Clinical monitoring of hemoglobin and hematocrit (H/H), platelet count, prothrombin time (PT) and activated partial prothrombin time (aPTT) is recommended prior to initiation of, during and following gp11b/111a platelet inhibitor therapy.

Major

Tirofiban (applies to tirofiban) renal dysfunction

Major Potential Hazard, High plausibility.

Tirofiban is primarily eliminated by the kidney. Approximately 65% of tirofiban is excreted in the urine, largely unchanged. The serum concentration of tirofiban is significantly increased (>50%) in patients with a creatinine clearance <30 mL/min (including hemodialysis patients). Therapy with tirofiban should be administered cautiously and initiated at a reduced dosage in patients with severe renal impairment. Clinical monitoring of renal function and bleeding activity is recommended. Tirofiban is removed by dialysis.

Switch to professional interaction data

Tirofiban drug interactions

There are 149 drug interactions with tirofiban.

Tirofiban alcohol/food interactions

There is 1 alcohol/food interaction with tirofiban.


Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

See also:

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.