Selexipag Disease Interactions
There are 2 disease interactions with selexipag.
Selexipag (applies to selexipag) liver impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Liver impairment can increase exposure to selexipag and its metabolites. No dose adjustment is necessary in patients with mild impairment, but a once a day regimen is recommended in patients with moderate hepatic impairment. There is no experience with selexipag in patients with severe hepatic impairment and its use should be avoided in these patients.
References
- (2016) "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc
Selexipag (applies to selexipag) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
No adjustment to the dosing regimen of selexipag is required in patients with estimated glomerular filtration rate > 15 mL/min/1.73m2. There is no clinical experience with selexipag in patients with glomerular filtration rates lower than this, or in patients undergoing dialysis.
References
- (2016) "Product Information. Uptravi (selexipag)." Actelion Pharmaceuticals US Inc
Selexipag drug interactions
There are 230 drug interactions with selexipag.
Selexipag alcohol/food interactions
There is 1 alcohol/food interaction with selexipag.
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- Drug class: agents for pulmonary hypertension
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
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