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Nplate (romiplostim) Disease Interactions

There are 3 disease interactions with Nplate (romiplostim):

Major

Romiplostim (Includes Nplate) ↔ Leukemia

Severe Potential Hazard, Moderate plausibility

Applies to: Myelodysplastic Disease, Leukemia

Progression from myelodysplastic syndromes (MDS) to acute myelogenous leukemia (AML) has been observed in clinical trials with romiplostim. This drug is not indicated for the treatment of thrombocytopenia due to MDS or any other cause other than chronic ITP.

Moderate

Romiplostim (Includes Nplate) ↔ Hepatic Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Liver Disease

No clinical studies with romiplostim have been conducted in patients with hepatic impairment.

Moderate

Romiplostim (Includes Nplate) ↔ Renal Impairment

Moderate Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

No clinical studies with romiplostim have been conducted in patients with renal impairment.

Nplate (romiplostim) drug Interactions

There is 1 drug interaction with Nplate (romiplostim)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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