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Riociguat Disease Interactions

There are 3 disease interactions with riociguat:

Moderate

Riociguat (Includes riociguat) ↔ hypotension

Moderate Potential Hazard, Moderate plausibility. Applies to: Hypotension, Hypertension

Riociguat reduces blood pressure. There is a potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensive agents. Caution is advised when using riociguat in these patients.

Moderate

Riociguat (Includes riociguat) ↔ liver impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Liver Disease

The safety and efficacy of riociguat have not been demonstrated in patients with severe hepatic impairment (Child-Pugh C). Care should be exercised when using riociguat in these patients.

Moderate

Riociguat (Includes riociguat) ↔ renal impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

The safety and efficacy of riociguat have not been demonstrated in patients with creatinine clearance < 15 mL/min or on dialysis. Care should be exercised when using riociguat in these patients.

Riociguat drug interactions

There are 392 drug interactions with riociguat

Riociguat alcohol/food interactions

There are 2 alcohol/food interactions with riociguat

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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