Riociguat Disease Interactions
There are 3 disease interactions with riociguat:
Riociguat (Includes Riociguat) ↔ Hypotension
Moderate Potential Hazard, Moderate plausibility
Applies to: Hypotension, Hypertension
Riociguat reduces blood pressure. There is a potential for symptomatic hypotension or ischemia in patients with hypovolemia, severe left ventricular outflow obstruction, resting hypotension, autonomic dysfunction, or concomitant treatment with antihypertensive agents. Caution is advised when using riociguat in these patients.
Riociguat (Includes Riociguat) ↔ Liver Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
The safety and efficacy of riociguat have not been demonstrated in patients with severe hepatic impairment (Child-Pugh C). Care should be exercised when using riociguat in these patients.
Riociguat (Includes Riociguat) ↔ Renal Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction
The safety and efficacy of riociguat have not been demonstrated in patients with creatinine clearance < 15 mL/min or on dialysis. Care should be exercised when using riociguat in these patients.
riociguat drug Interactions
There are 383 drug interactions with riociguat
riociguat alcohol/food Interactions
There are 2 alcohol/food interactions with riociguat
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
Disclaimer: Every effort has been made to ensure that the information provided by Multum is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. Multum's information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill, knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2018 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.
