Pralatrexate Disease Interactions
There are 2 disease interactions with pralatrexate:
Pralatrexate (Includes Pralatrexate) ↔ Liver Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
The safety, efficacy and pharmacokinetics of pralatrexate have not been evaluated in patients with hepatic impairment. Additionally, this drug can cause hepatotoxicity and liver function test abnormalities, which might require dose modification or discontinuation. Caution and monitoring is advised.
Pralatrexate (Includes Pralatrexate) ↔ Renal Impairment
Moderate Potential Hazard, Moderate plausibility
Applies to: Renal Dysfunction
Patients with moderate to severe renal function impairment may be at greater risk of toxicity due to increased exposure. Patients should be monitored for renal function and toxicity and dosage should be adjusted accordingly. For patients with severe renal impairment (GFR 15 to <30), the recommended dose of pralatrexate is 15 mg/m2. Avoid the use of pralatrexate in patients with ESRD undergoing dialysis, unless the potential effect justifies the potential risk.
pralatrexate drug Interactions
There are 232 drug interactions with pralatrexate
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No information available. |
Do not stop taking any medications without consulting your healthcare provider.
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