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Nilutamide Disease Interactions

There are 2 disease interactions with nilutamide:

Major

Nilutamide (Includes Nilutamide) ↔ Hepatic Dysfunction

Severe Potential Hazard, High plausibility

Applies to: Liver Disease

The use of nilutamide is contraindicated in patients with severe hepatic impairment. Patients with hepatic dysfunction may be at increased risk for nilutamide- associated hepatitis and marked increases in liver enzymes. Nilutamide is extensively metabolized by the liver and the metabolic activity and disposition of nilutamide may be altered in patients with severe hepatic impairment. Patients should be instructed to immediately report any sign or symptoms of hepatic dysfunction such as jaundice, dark urine, right upper quadrant pain, or anorexia. Clinical monitoring of hepatic function is recommended and nilutamide should be discontinued if liver transaminase levels increase two to three times the upper limit of normal.

References

  1. Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F "Simultanwous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med 92 (1992): 563-6
  2. "Product Information. Nilandron (nilutamide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  3. Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F "Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med 92 (1992): 563-6
Major

Nilutamide (Includes Nilutamide) ↔ Interstitial Pneumonitis

Severe Potential Hazard, High plausibility

Applies to: Interstitial Pneumonitis

The use of nilutamide is contraindicated in patients with severe respiratory impairment. Patients with pulmonary dysfunction may be at increased risk for nilutamide- associated interstitial pneumonitis. Patients should be instructed to immediately report any signs or symptoms of respiratory impairment such as dyspnea, cough, chest pain, or fever. Clinical monitoring of pulmonary function, including pre-treatment chest X-ray, is recommended.

References

  1. Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F "Simultanwous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med 92 (1992): 563-6
  2. Gomez JL, Dupont A, Cusan L, Tremblay M, Tremblay M, Labrie F "Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report." Am J Med 92 (1992): 563-6
  3. "Product Information. Nilandron (nilutamide)." Hoechst Marion-Roussel Inc, Kansas City, MO.
  4. Wieder JA, Soloway MS "Interstitial pneumonitis associated with neoadjuvant leuprolide and nilutamide for prostate cancer." J Urol 159 (1998): 2099
View all 4 references

nilutamide drug Interactions

There are 220 drug interactions with nilutamide

nilutamide alcohol/food Interactions

There is 1 alcohol/food interaction with nilutamide

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

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